| UniProt Protein Function: | Plays a role in mediating store-operated Ca2+ entry (SOCE), a Ca2+ influx following depletion of intracellular Ca2+ stores. Functions as a highly sensitive Ca2+ sensor in the endoplasmic reticulum which activates both store-operated and store-independent Ca2+-influx. Regulates basal cytosolic and endoplasmic reticulum Ca2+ concentrations. Upon mild variations of the endoplasmic reticulum Ca2+ concentration, translocates from the endoplasmic reticulum to the plasma membrane where it probably activates the Ca2+ release-activated Ca2+ (CRAC) channels ORAI1, ORAI2 and ORAI3. May inhibit STIM1-mediated Ca2+ influx. |
| NCBI Summary: | This gene is a member of the stromal interaction molecule (STIM) family and likely arose, along with related family member STIM1, from a common ancestral gene. The encoded protein functions to regulate calcium concentrations in the cytosol and endoplasmic reticulum, and is involved in the activation of plasma membrane Orai Ca(2+) entry channels. This gene initiates translation from a non-AUG (UUG) start site. A signal peptide is cleaved from the resulting protein. Multiple transcript variants result from alternative splicing. [provided by RefSeq, Dec 2009] |
| UniProt Code: | Q9P246 |
| NCBI GenInfo Identifier: | 17369338 |
| NCBI Gene ID: | 57620 |
| NCBI Accession: | Q9P246.2 |
| UniProt Secondary Accession: | Q9P246,Q96BF1, Q9BQH2, Q9H8R1, A6H8L7, B7ZVY0, |
| UniProt Related Accession: | Q9P246 |
| Molecular Weight: | 68,026 Da |
| NCBI Full Name: | Stromal interaction molecule 2 |
| NCBI Synonym Full Names: | stromal interaction molecule 2 |
| NCBI Official Symbol: | STIM2 |
| NCBI Protein Information: | stromal interaction molecule 2 |
| UniProt Protein Name: | Stromal interaction molecule 2 |
| Protein Family: | Stromal interaction molecule |
| UniProt Gene Name: | STIM2 |
| UniProt Entry Name: | STIM2_HUMAN |
