Anti-STC2 Antibody (CAB10397)
- SKU:
- CAB10397
- Product type:
- Antibody
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Frequently bought together:
Description
| 抗体名: | Anti-STC2 Antibody |
| 抗体コード: | CAB10397 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB |
| 反応性: | Mouse, Rat |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 25-302 of human STC2 (NP_003705.1). |
| 申し込み: | WB |
| 推奨希釈: | WB 1:500 - 1:2000 |
| 反応性: | Mouse, Rat |
| ポジティブサンプル: | Mouse heart, Mouse skeletal muscle |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 25-302 of human STC2 (NP_003705.1). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | TDAT NPPE GPQD RSSQ QKGR LSLQ NTAE IQHC LVNA GDVG CGVF ECFE NNSC EIRG LHGI CMTF LHNA GKFD AQGK SFIK DALK CKAH ALRH RFGC ISRK CPAI REMV SQLQ RECY LKHD LCAA AQEN TRVI VEMI HFKD LLLH EPYV DLVN LLLT CGEE VKEA ITHS VQVQ CEQN WGSL CSIL SFCT SAIQ KPPT APPE RQPQ VDRT KLSR AHHG EAGH HLPE PSSR ETGR GAKG ERGS KSHP NAHA RGRV GGLG AQGP SGSS EWED EQSE YSDI RR |
| 遺伝子ID: | 8614 |
| Uniprot: | O76061 |
| セルラーロケーション: | Secreted |
| 計算された分子量: | 33kDa |
| 観察された分子量: | 25-33kDa |
| 同義語: | STC2, STC-2, STCRP |
| バックグラウンド: | This gene encodes a secreted, homodimeric glycoprotein that is expressed in a wide variety of tissues and may have autocrine or paracrine functions. The encoded protein has 10 of its 15 cysteine residues conserved among stanniocalcin family members and is phosphorylated by casein kinase 2 exclusively on its serine residues. Its C-terminus contains a cluster of histidine residues which may interact with metal ions. The protein may play a role in the regulation of renal and intestinal calcium and phosphate transport, cell metabolism, or cellular calcium/phosphate homeostasis. Constitutive overexpression of human stanniocalcin 2 in mice resulted in pre- and postnatal growth restriction, reduced bone and skeletal muscle growth, and organomegaly. Expression of this gene is induced by estrogen and altered in some breast cancers. |
| UniProt Protein Function: | STC2: a secreted protein that has an anti-hypocalcemic action on calcium and phosphate homeostasis. Expressed in a variety of tissues including muscle, heart, pancreas, kidney, spleen, prostate, small intestine, colon and peripheral blood leucocytes. |
| UniProt Protein Details: | Protein type:Secreted; Secreted, signal peptide Chromosomal Location of Human Ortholog: 5q35.1 Cellular Component: endoplasmic reticulum; extracellular space; perinuclear region of cytoplasm Molecular Function:enzyme binding; heme binding; protein homodimerization activity Biological Process: regulation of hormone biosynthetic process |
| NCBI Summary: | This gene encodes a secreted, homodimeric glycoprotein that is expressed in a wide variety of tissues and may have autocrine or paracrine functions. The encoded protein has 10 of its 15 cysteine residues conserved among stanniocalcin family members and is phosphorylated by casein kinase 2 exclusively on its serine residues. Its C-terminus contains a cluster of histidine residues which may interact with metal ions. The protein may play a role in the regulation of renal and intestinal calcium and phosphate transport, cell metabolism, or cellular calcium/phosphate homeostasis. Constitutive overexpression of human stanniocalcin 2 in mice resulted in pre- and postnatal growth restriction, reduced bone and skeletal muscle growth, and organomegaly. Expression of this gene is induced by estrogen and altered in some breast cancers. [provided by RefSeq, Jul 2008] |
| UniProt Code: | O76061 |
| NCBI GenInfo Identifier: | 7388262 |
| NCBI Gene ID: | 8614 |
| NCBI Accession: | O76061.1 |
| UniProt Related Accession: | O76061 |
| Molecular Weight: | 33,249 Da |
| NCBI Full Name: | Stanniocalcin-2 |
| NCBI Synonym Full Names: | stanniocalcin 2 |
| NCBI Official Symbol: | STC2 |
| NCBI Official Synonym Symbols: | STC-2; STCRP |
| NCBI Protein Information: | stanniocalcin-2 |
| UniProt Protein Name: | Stanniocalcin-2 |
| UniProt Synonym Protein Names: | Stanniocalcin-related protein; STC-related protein; STCRP |
| Protein Family: | Stanniocalcin |
| UniProt Gene Name: | STC2 |
| UniProt Entry Name: | STC2_HUMAN |
 | Western blot analysis of extracts of various cell lines, using STC2 antibody (CAB10397) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s. |
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