Anti-STAT6 Antibody (RACO0544)
- SKU:
- RACO0544
- Product type:
- Recombinant Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Human
- Isotype:
- IgG
- Application:
- WB
- Application:
- ELISA
- Application:
- IHC
- Conjugation:
- Unconjugated
Frequently bought together:
Description
| 商品名: | STAT6 Antibody |
| Product SKU: | RACO0544 |
| サイズ: | 50ul |
| 宿主種: | Homo sapiens (Human) |
| 申し込み: | ELISA, WB, IHC |
| 推奨される希釈: | WB:1:500-1:5000, IHC:1:50-1:200 |
| 反応性: | Human, Mouse |
| 免疫原: | A synthesized peptide derived from human STAT6 |
| 憲法: | Liquid |
| ストレージバッファ: | Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| 精製方法: | Affinity-chromatography |
| 抗体のクローン性: | Monoclonal |
| アイソタイプ: | Rabbit IgG |
| Conjugate: | Non-conjugated |
| バックグラウンド: | Carries out a dual function: signal transduction and activation of transcription. Involved in IL4/interleukin-4- and IL3/interleukin-3-mediated signaling. |
| シノニム: | Signal transducer and activator of transcription 6 (IL-4 Stat), STAT6 |
 | IHC image of RACO0544 diluted at 1:100 and staining in paraffin-embedded human kidney tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a Goat anti-rabbit IgG polymer labeled by HRP and visualized using 0.05% DAB. |
 | Western Blot. Positive WB detected in Hela whole cell lysate 293 whole cell lysate HepG2 whole cell lysate NIH/3T3 whole cell lysate K562 whole cell lysate All lanes STAT6 Antibody at 1:1000. Secondary. Goat polyclonal to rabbit IgG at 1:50000 dilution. Predicted band size: 95, 75, 82 kDa. Observed band size: 100 kDa. |
| UniProt Protein Function: | STAT6: transcription factor of the STAT family. Plays a central role in IL4-mediated biological responses. Induces the expression of BCL2L1/BCL-X(L), which is responsible for the anti-apoptotic activity of IL4. May function in the differentiation of T helper 2 cells and class switch of immunoglobulins. Forms homo- or heterodimers that translocate into the nucleus where they regulate transcription. |
| UniProt Protein Details: | Protein type:DNA-binding; Transcription factor Chromosomal Location of Human Ortholog: 12q13 Cellular Component: cytoplasm; cytosol; lipid raft; nuclear chromatin; nucleoplasm Molecular Function:identical protein binding; protein binding; protein phosphatase binding; signal transducer activity; transcription factor activity Biological Process: mammary gland epithelial cell proliferation; negative regulation of T-helper 2 type immune response; negative regulation of transcription from RNA polymerase II promoter; positive regulation of interferon type I production; positive regulation of isotype switching to IgE isotypes; positive regulation of transcription from RNA polymerase II promoter; regulation of cell proliferation; regulation of transcription from RNA polymerase II promoter; signal transduction; T-helper 1 cell lineage commitment; transcription, DNA-dependent |
| NCBI Summary: | The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein plays a central role in exerting IL4 mediated biological responses. It is found to induce the expression of BCL2L1/BCL-X(L), which is responsible for the anti-apoptotic activity of IL4. Knockout studies in mice suggested the roles of this gene in differentiation of T helper 2 (Th2) cells, expression of cell surface markers, and class switch of immunoglobulins. Alternative splicing results in multiple transcript variants.[provided by RefSeq, May 2010] |
| UniProt Code: | P42226 |
| NCBI GenInfo Identifier: | 1174459 |
| NCBI Gene ID: | 6778 |
| NCBI Accession: | P42226.1 |
| UniProt Secondary Accession: | P42226,Q5FBW5, Q71UP4, A8K316, B7ZA27, F5GXI9, |
| UniProt Related Accession: | P42226 |
| Molecular Weight: | |
| NCBI Full Name: | Signal transducer and activator of transcription 6 |
| NCBI Synonym Full Names: | signal transducer and activator of transcription 6 |
| NCBI Official Symbol: | STAT6 |
| NCBI Official Synonym Symbols: | STAT6B; STAT6C; D12S1644; IL-4-STAT |
| NCBI Protein Information: | signal transducer and activator of transcription 6 |
| UniProt Protein Name: | Signal transducer and activator of transcription 6 |
| UniProt Synonym Protein Names: | IL-4 Stat |
| Protein Family: | Signal transducer and transcription activator |
| UniProt Gene Name: | STAT6 |
| UniProt Entry Name: | STAT6_HUMAN |