Anti-STAT5A Antibody (CAB11779)
- SKU:
- CAB11779
- Product type:
- Antibody
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
抗体名: | Anti-STAT5A Antibody |
抗体コード: | CAB11779 |
抗体サイズ: | 20uL, 50uL, 100uL |
申し込み: | WB |
反応性: | Mouse, Rat |
宿主種: | Rabbit |
免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-250 of human STAT5A (NP_003143.2). |
申し込み: | WB |
推奨希釈: | WB 1:500 - 1:2000 |
反応性: | Mouse, Rat |
ポジティブサンプル: | Mouse heart, Mouse lung, Mouse liver, Rat heart, Rat lung |
免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-250 of human STAT5A (NP_003143.2). |
精製方法: | Affinity purification |
ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
アイソタイプ: | IgG |
順序: | MAGW IQAQ QLQG DALR QMQV LYGQ HFPI EVRH YLAQ WIES QPWD AIDL DNPQ DRAQ ATQL LEGL VQEL QKKA EHQV GEDG FLLK IKLG HYAT QLQK TYDR CPLE LVRC IRHI LYNE QRLV REAN NCSS PAGI LVDA MSQK HLQI NQTF EELR LVTQ DTEN ELKK LQQT QEYF IIQY QESL RIQA QFAQ LAQL SPQE RLSR ETAL QQKQ VSLE AWLQ REAQ TLQQ YRVE LAEK HQKT LQLL RKQQ TIIL DD |
遺伝子ID: | 6776 |
Uniprot: | P42229 |
セルラーロケーション: | Cytoplasm, Nucleus |
計算された分子量: | 86kDa/90kDa |
観察された分子量: | 90kDa |
同義語: | MGF, STAT5, STAT5A |
バックグラウンド: | The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated by, and mediates the responses of many cell ligands, such as IL2, IL3, IL7 GM-CSF, erythropoietin, thrombopoietin, and different growth hormones. Activation of this protein in myeloma and lymphoma associated with a TEL/JAK2 gene fusion is independent of cell stimulus and has been shown to be essential for tumorigenesis. The mouse counterpart of this gene is found to induce the expression of BCL2L1/BCL-X(L), which suggests the antiapoptotic function of this gene in cells. Alternatively spliced transcript variants have been found for this gene. |
UniProt Protein Function: | STAT5A: transcription factor of the STAT family. Phosphorylated and activated by receptor-associated kinases downstream of many cytokines and growth-factor receptors. Activation of this protein in myeloma and lymphoma associated with a TEL/JAK2 fusion protein is essential for the tumorigenesis. Induces the expression of BCL2L1/BCL-X(L) in the mouse, suggesting an antiapoptotic function of this protein. Forms homo- or heterodimers that translocate into the nucleus where they regulate transcription. Two alternatively spliced isoforms have been described. |
UniProt Protein Details: | Protein type:DNA-binding; Transcription factor; Motility/polarity/chemotaxis; Oncoprotein Chromosomal Location of Human Ortholog: 17q11.2 Cellular Component: nucleoplasm; cytosol Molecular Function:signal transducer activity; protein binding; transcription factor activity Biological Process: lactation; succinate metabolic process; oxaloacetate metabolic process; peptidyl-tyrosine phosphorylation; positive regulation of interleukin-2 biosynthetic process; T cell differentiation in the thymus; positive regulation of multicellular organism growth; female pregnancy; positive regulation of mitotic cell cycle; fatty acid metabolic process; positive regulation of activated T cell proliferation; 2-oxoglutarate metabolic process; positive regulation of natural killer cell differentiation; sequestering of lipid; natural killer cell differentiation; allantoin metabolic process; negative regulation of mast cell apoptosis; luteinization; development of secondary male sexual characteristics; regulation of steroid metabolic process; creatinine metabolic process; T cell homeostasis; positive regulation of gamma-delta T cell differentiation; Peyer's patch development; isoleucine metabolic process; negative regulation of erythrocyte differentiation; transcription, DNA-dependent; regulation of multicellular organism growth; citrate metabolic process; valine metabolic process; development of secondary female sexual characteristics; positive regulation of natural killer cell mediated cytotoxicity; JAK-STAT cascade; creatine metabolic process; regulation of transcription from RNA polymerase II promoter; regulation of epithelial cell differentiation; positive regulation of B cell differentiation; positive regulation of transcription from RNA polymerase II promoter; taurine metabolic process; positive regulation of inflammatory response |
NCBI Summary: | The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated by, and mediates the responses of many cell ligands, such as IL2, IL3, IL7 GM-CSF, erythropoietin, thrombopoietin, and different growth hormones. Activation of this protein in myeloma and lymphoma associated with a TEL/JAK2 gene fusion is independent of cell stimulus and has been shown to be essential for tumorigenesis. The mouse counterpart of this gene is found to induce the expression of BCL2L1/BCL-X(L), which suggests the antiapoptotic function of this gene in cells. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Dec 2013] |
UniProt Code: | P42229 |
NCBI GenInfo Identifier: | 1174462 |
NCBI Gene ID: | 6776 |
NCBI Accession: | P42229.1 |
UniProt Secondary Accession: | P42229,Q1KLZ6, |
UniProt Related Accession: | P42229 |
Molecular Weight: | |
NCBI Full Name: | Signal transducer and activator of transcription 5A |
NCBI Synonym Full Names: | signal transducer and activator of transcription 5A |
NCBI Official Symbol: | STAT5A |
NCBI Official Synonym Symbols: | MGF; STAT5 |
NCBI Protein Information: | signal transducer and activator of transcription 5A |
UniProt Protein Name: | Signal transducer and activator of transcription 5A |
Protein Family: | Signal transducer and activator of transcription |
UniProt Gene Name: | STAT5A |
UniProt Entry Name: | STA5A_HUMAN |