| バックグラウンド: | Cholesterol homeostasis is regulated, at least in part, by sterol regulatory element (SRE)-binding proteins (e.g., SREBP1; MIM 184756) and by liver X receptors (e.g., LXRA; MIM 602423). Upon sterol depletion, LXRs are inactive and SREBPs are cleaved, after which they bind promoter SREs and activate genes involved in cholesterol biosynthesis and uptake. Sterol transport is mediated by vesicles or by soluble protein carriers, such as steroidogenic acute regulatory protein (STAR; MIM 600617). STAR is homologous to a family of proteins containing a 200- to 210-amino acid STAR-related lipid transfer (START) domain, including STARD4 (Soccio et al., 2002 [PubMed 12011452]). |
| UniProt Protein Function: | STARD4: May be involved in the intracellular transport of sterols or other lipids. May bind cholesterol or other sterols. |
| UniProt Protein Details: | Chromosomal Location of Human Ortholog: 5q22.1 Cellular Component: cytoplasmic membrane-bound vesicle |
| NCBI Summary: | Cholesterol homeostasis is regulated, at least in part, by sterol regulatory element (SRE)-binding proteins (e.g., SREBP1; MIM 184756) and by liver X receptors (e.g., LXRA; MIM 602423). Upon sterol depletion, LXRs are inactive and SREBPs are cleaved, after which they bind promoter SREs and activate genes involved in cholesterol biosynthesis and uptake. Sterol transport is mediated by vesicles or by soluble protein carriers, such as steroidogenic acute regulatory protein (STAR; MIM 600617). STAR is homologous to a family of proteins containing a 200- to 210-amino acid STAR-related lipid transfer (START) domain, including STARD4 (Soccio et al., 2002 [PubMed 12011452]).[supplied by OMIM, Mar 2008] |
| UniProt Code: | Q96DR4 |
| NCBI GenInfo Identifier: | 25091316 |
| NCBI Gene ID: | 134429 |
| NCBI Accession: | Q96DR4.1 |
| UniProt Secondary Accession: | Q96DR4,Q86TN9, |
| UniProt Related Accession: | Q96DR4 |
| Molecular Weight: | 18,517 Da |
| NCBI Full Name: | StAR-related lipid transfer protein 4 |
| NCBI Synonym Full Names: | StAR related lipid transfer domain containing 4 |
| NCBI Official Symbol: | STARD4 |
| NCBI Protein Information: | stAR-related lipid transfer protein 4 |
| UniProt Protein Name: | StAR-related lipid transfer protein 4 |
| UniProt Synonym Protein Names: | START domain-containing protein 4; StARD4 |
| Protein Family: | StAR-related lipid transfer protein |
| UniProt Gene Name: | STARD4 |
| UniProt Entry Name: | STAR4_HUMAN |
