Anti-STAM2 Antibody (CAB7058)
- SKU:
- CAB7058
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Frequently bought together:
Description
| 抗体名: | Anti-STAM2 Antibody |
| 抗体コード: | CAB7058 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB IF |
| 反応性: | Human, Mouse, Rat |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 376-525 of human STAM2 (NP_005834.4). |
| 申し込み: | WB IF |
| 推奨希釈: | WB 1:500 - 1:2000 IF 1:50 - 1:100 |
| 反応性: | Human, Mouse, Rat |
| ポジティブサンプル: | MCF7, HepG2, OVCAR3, PC-3 |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 376-525 of human STAM2 (NP_005834.4). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | KLHP PAHY PPAS SGVP MQTY PVQS HGGN YMGQ SIHQ VTVA QSYS LGPD QIGP LRSL PPNV NSSV TAQP AQTS YLST GQDT VSNP TYMN QNSN LQSA TGTT AYTQ QMGM SVDM SSYQ NTTS NLPQ LAGF PVTV PAHP VAQQ HTNY HQQP LL |
| 遺伝子ID: | 10254 |
| Uniprot: | O75886 |
| セルラーロケーション: | Cytoplasm, Cytoplasmic side, Early endosome membrane, Peripheral membrane protein |
| 計算された分子量: | 38kDa/58kDa |
| 観察された分子量: | 70kDa |
| 同義語: | STAM2, Hbp, STAM2A, STAM2B |
| バックグラウンド: | The protein encoded by this gene is closely related to STAM, an adaptor protein involved in the downstream signaling of cytokine receptors, both of which contain a SH3 domain and the immunoreceptor tyrosine-based activation motif (ITAM). Similar to STAM, this protein acts downstream of JAK kinases, and is phosphorylated in response to cytokine stimulation. This protein and STAM thus are thought to exhibit compensatory effects on the signaling pathway downstream of JAK kinases upon cytokine stimulation. |
| UniProt Protein Function: | STAM2: an adaptor protein involved in the downstream signaling of cytokine receptors. Contain a SH3 domain and immunoreceptor tyrosine-based activation motif (ITAM). Acts downstream of JAK kinases, and is phosphorylated in response to cytokine stimulation. May modulate the signaling pathway downstream of JAK kinases upon cytokine stimulation. |
| UniProt Protein Details: | Protein type:Adaptor/scaffold; Motility/polarity/chemotaxis Chromosomal Location of Human Ortholog: 2q23.3 Cellular Component: cytoplasm; cytosol; intracellular membrane-bound organelle; nucleoplasm Molecular Function:protein binding Biological Process: autophagy; endosome transport; negative regulation of epidermal growth factor receptor signaling pathway |
| NCBI Summary: | The protein encoded by this gene is closely related to STAM, an adaptor protein involved in the downstream signaling of cytokine receptors, both of which contain a SH3 domain and the immunoreceptor tyrosine-based activation motif (ITAM). Similar to STAM, this protein acts downstream of JAK kinases, and is phosphorylated in response to cytokine stimulation. This protein and STAM thus are thought to exhibit compensatory effects on the signaling pathway downstream of JAK kinases upon cytokine stimulation. [provided by RefSeq, Jul 2008] |
| UniProt Code: | O75886 |
| NCBI GenInfo Identifier: | 71153548 |
| NCBI Gene ID: | 10254 |
| NCBI Accession: | O75886.1 |
| UniProt Secondary Accession: | O75886,Q7LDQ0, Q9UF58, A8K8A0, D3DPA1, |
| UniProt Related Accession: | O75886 |
| Molecular Weight: | 38,370 Da |
| NCBI Full Name: | Signal transducing adapter molecule 2 |
| NCBI Synonym Full Names: | signal transducing adaptor molecule 2 |
| NCBI Official Symbol: | STAM2 |
| NCBI Official Synonym Symbols: | Hbp; STAM2A; STAM2B |
| NCBI Protein Information: | signal transducing adapter molecule 2 |
| UniProt Protein Name: | Signal transducing adapter molecule 2 |
| UniProt Synonym Protein Names: | Hrs-binding protein |
| Protein Family: | Signal transducing adapter molecule |
| UniProt Gene Name: | STAM2 |
| UniProt Entry Name: | STAM2_HUMAN |
 | Western blot analysis of extracts of various cell lines, using STAM2 antibody (CAB7058) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 1s. |
 | Immunofluorescence analysis of C6 cells using STAM2 antibody (CAB7058) at dilution of 1:100. Blue: DAPI for nuclear staining. |
 | Immunofluorescence analysis of L929 cells using STAM2 antibody (CAB7058) at dilution of 1:100. Blue: DAPI for nuclear staining. |
 | Immunofluorescence analysis of U-2 OS cells using STAM2 antibody (CAB7058) at dilution of 1:100. Blue: DAPI for nuclear staining. |
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