Anti-STAM Antibody (CAB4198)
- SKU:
- CAB4198
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
Frequently bought together:
Description
抗体名: | Anti-STAM Antibody |
抗体コード: | CAB4198 |
抗体サイズ: | 20uL, 50uL, 100uL |
申し込み: | WB IHC |
反応性: | Human, Mouse, Rat |
宿主種: | Rabbit |
免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 120-210 of human STAM (NP_003464.1). |
申し込み: | WB IHC |
推奨希釈: | WB 1:200 - 1:1000 IHC 1:20 - 1:100 |
反応性: | Human, Mouse, Rat |
ポジティブサンプル: | SH-SY5Y, Jurkat, HeLa, HepG2, Mouse pancreas, Rat liver |
免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 120-210 of human STAM (NP_003464.1). |
精製方法: | Affinity purification |
ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
アイソタイプ: | IgG |
順序: | KNDP QLSL ISAM IKNL KEQG VTFP AIGS QAAE QAKA SPAL VAKD PGTV ANKK EEED LAKA IELS LKEQ RQQS TTLS TLYP STSS LLTN HQH |
遺伝子ID: | 8027 |
Uniprot: | Q92783 |
セルラーロケーション: | Cytoplasm, Cytoplasmic side, Early endosome membrane, Peripheral membrane protein |
計算された分子量: | 44kDa/59kDa |
観察された分子量: | 70kDa |
同義語: | STAM, STAM-1, STAM1 |
バックグラウンド: | This gene encodes a member of the signal-transducing adaptor molecule family. These proteins mediate downstream signaling of cytokine receptors and also play a role in ER to Golgi trafficking by interacting with the coat protein II complex. The encoded protein also associates with hepatocyte growth factor-regulated substrate to form the endosomal sorting complex required for transport-0 (ESCRT-0), which sorts ubiquitinated membrane proteins to the ESCRT-1 complex for lysosomal degradation. Alternatively spliced transcript variants have been observed for this gene. |
UniProt Protein Function: | STAM1: Involved in intracellular signal transduction mediated by cytokines and growth factors. Upon IL-2 and GM-CSL stimulation, it plays a role in signaling leading to DNA synthesis and MYC induction. May also play a role in T-cell development. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with HGS (ESCRT-0 complex). The ESCRT-0 complex binds ubiquitin and acts as sorting machinery that recognizes ubiquitinated receptors and transfers them to further sequential lysosomal sorting/trafficking processes. Belongs to the STAM family. 2 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:Motility/polarity/chemotaxis; Adaptor/scaffold Chromosomal Location of Human Ortholog: 10p14-p13 Cellular Component: early endosome membrane; cytosol Molecular Function:protein binding; SH3/SH2 adaptor activity Biological Process: negative regulation of epidermal growth factor receptor signaling pathway; epidermal growth factor receptor signaling pathway; intracellular protein transport; positive regulation of signal transduction; signal transduction; endosome transport |
NCBI Summary: | This gene encodes a member of the signal-transducing adaptor molecule family. These proteins mediate downstream signaling of cytokine receptors and also play a role in ER to Golgi trafficking by interacting with the coat protein II complex. The encoded protein also associates with hepatocyte growth factor-regulated substrate to form the endosomal sorting complex required for transport-0 (ESCRT-0), which sorts ubiquitinated membrane proteins to the ESCRT-1 complex for lysosomal degradation. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Feb 2011] |
UniProt Code: | Q92783 |
NCBI GenInfo Identifier: | 71153545 |
NCBI Gene ID: | 8027 |
NCBI Accession: | Q92783.3 |
UniProt Related Accession: | Q92783 |
Molecular Weight: | |
NCBI Full Name: | Signal transducing adapter molecule 1 |
NCBI Synonym Full Names: | signal transducing adaptor molecule |
NCBI Official Symbol: | STAM |
NCBI Official Synonym Symbols: | STAM1; STAM-1 |
NCBI Protein Information: | signal transducing adapter molecule 1 |
UniProt Protein Name: | Signal transducing adapter molecule 1 |
Protein Family: | STAM-binding protein |
UniProt Gene Name: | STAM |
UniProt Entry Name: | STAM1_HUMAN |
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