Anti-ST3GAL5 Antibody (CAB7947)
- SKU:
- CAB7947
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Frequently bought together:
Description
| 抗体名: | Anti-ST3GAL5 Antibody |
| 抗体コード: | CAB7947 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB |
| 反応性: | Human, Mouse, Rat |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 80-200 of human ST3GAL5 (NP_003887.3). |
| 申し込み: | WB |
| 推奨希釈: | WB 1:500 - 1:2000 |
| 反応性: | Human, Mouse, Rat |
| ポジティブサンプル: | BT-474, U-251MG, SH-SY5Y, Mouse brain, Rat brain |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 80-200 of human ST3GAL5 (NP_003887.3). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | LYIL KLNY TTEE CDMK KMHY VDPD HVKR AQKY AQQV LQKE CRPK FAKT SMAL LFEH RYSV DLLP FVQK APKD SEAE SKYD PPFG FRKF SSKV QTLL ELLP EHDL PEHL KAKT CRRC VVIG S |
| 遺伝子ID: | 8869 |
| Uniprot: | Q9UNP4 |
| セルラーロケーション: | Golgi apparatus membrane, Single-pass type II membrane protein |
| 計算された分子量: | 45kDa/47kDa |
| 観察された分子量: | 48kDa |
| 同義語: | ST3GAL5, SATI, SIAT9, SIATGM3S, SPDRS, ST3GalV |
| バックグラウンド: | Ganglioside GM3 is known to participate in the induction of cell differentiation, modulation of cell proliferation, maintenance of fibroblast morphology, signal transduction, and integrin-mediated cell adhesion. The protein encoded by this gene is a type II membrane protein which catalyzes the formation of GM3 using lactosylceramide as the substrate. The encoded protein is a member of glycosyltransferase family 29 and may be localized to the Golgi apparatus. Mutation in this gene has been associated with Amish infantile epilepsy syndrome. Transcript variants encoding different isoforms have been found for this gene. |
| UniProt Protein Function: | ST3GAL5: Catalyzes the formation of ganglioside GM3 (alpha-N- acetylneuraminyl-2,3-beta-D-galactosyl-1, 4-beta-D- glucosylceramide). Defects in ST3GAL5 are the cause of Amish infantile epilepsy syndrome (AIES). AIES is an autosomal recessive, infantile-onset symptomatic epilepsy associated with developmental stagnation and blindness. Belongs to the glycosyltransferase 29 family. 3 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Membrane protein, integral; Glycan Metabolism - glycosphingolipid biosynthesis - ganglio series; EC 2.4.99.9; Transferase Chromosomal Location of Human Ortholog: 2p11.2 Cellular Component: Golgi membrane; integral to plasma membrane; integral to membrane; integral to Golgi membrane Molecular Function:lactosylceramide alpha-2,3-sialyltransferase activity; neolactotetraosylceramide alpha-2,3-sialyltransferase activity; sialyltransferase activity Biological Process: cellular protein metabolic process; glycosphingolipid biosynthetic process; dolichol-linked oligosaccharide biosynthetic process; carbohydrate metabolic process; protein amino acid N-linked glycosylation via asparagine; post-translational protein modification; ganglioside biosynthetic process Disease: Amish Infantile Epilepsy Syndrome |
| NCBI Summary: | Ganglioside GM3 is known to participate in the induction of cell differentiation, modulation of cell proliferation, maintenance of fibroblast morphology, signal transduction, and integrin-mediated cell adhesion. The protein encoded by this gene is a type II membrane protein which catalyzes the formation of GM3 using lactosylceramide as the substrate. The encoded protein is a member of glycosyltransferase family 29 and may be localized to the Golgi apparatus. Mutation in this gene has been associated with Amish infantile epilepsy syndrome. Transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q9UNP4 |
| NCBI GenInfo Identifier: | 109633044 |
| NCBI Gene ID: | 8869 |
| NCBI Accession: | NP_003887.3 |
| UniProt Secondary Accession: | Q9UNP4,O94902, Q53QU1, Q6NZX4, Q6YFL1, B3KM82, D6W5L9 |
| UniProt Related Accession: | Q9UNP4 |
| Molecular Weight: | 45,585 Da |
| NCBI Full Name: | lactosylceramide alpha-2,3-sialyltransferase isoform 1 |
| NCBI Synonym Full Names: | ST3 beta-galactoside alpha-2,3-sialyltransferase 5 |
| NCBI Official Symbol: | ST3GAL5 |
| NCBI Official Synonym Symbols: | SATI; SIAT9; ST3GalV; SIATGM3S |
| NCBI Protein Information: | lactosylceramide alpha-2,3-sialyltransferase |
| UniProt Protein Name: | Lactosylceramide alpha-2,3-sialyltransferase |
| UniProt Synonym Protein Names: | CMP-NeuAc:lactosylceramide alpha-2,3-sialyltransferase; Ganglioside GM3 synthase; ST3Gal V; ST3GalV; Sialyltransferase 9 |
| Protein Family: | Lactosylceramide alpha-2,3-sialyltransferase |
| UniProt Gene Name: | ST3GAL5 |
| UniProt Entry Name: | SIAT9_HUMAN |
 | Western blot analysis of extracts of various cell lines, using ST3GAL5 antibody (CAB7947) at 1:1000 dilution._Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution._Lysates/proteins: 25ug per lane._Blocking buffer: 3% nonfat dry milk in TBST._Detection: ECL Enhanced Kit (RM00021)._Exposure time: 90s. |
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