Anti-SSTR4 Antibody (CAB6988)
- SKU:
- CAB6988
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Frequently bought together:
Description
| 抗体名: | Anti-SSTR4 Antibody |
| 抗体コード: | CAB6988 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB |
| 反応性: | Human, Mouse, Rat |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 314-388 of human SSTR4 (NP_001043.2). |
| 申し込み: | WB |
| 推奨希釈: | WB 1:500 - 1:2000 |
| 反応性: | Human, Mouse, Rat |
| ポジティブサンプル: | HL-60, BT-474, HepG2, Mouse brain, Rat brain, Rat lung |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 314-388 of human SSTR4 (NP_001043.2). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | LSDN FRRF FQRV LCLR CCLL EGAG GAEE EPLD YYAT ALKS KGGA GCMC PPLP CQQE ALQP EPGR KRIP LTRT TTF |
| 遺伝子ID: | 6754 |
| Uniprot: | P31391 |
| セルラーロケーション: | Cell membrane, Multi-pass membrane protein |
| 計算された分子量: | 42kDa |
| 観察された分子量: | 39kDa |
| 同義語: | SSTR4, SS-4-R, SS4-R, SS4R |
| バックグラウンド: | Somatostatin acts at many sites to inhibit the release of many hormones and other secretory proteins. The biologic effects of somatostatin are probably mediated by a family of G protein-coupled receptors that are expressed in a tissue-specific manner. SSTR4 is a member of the superfamily of receptors having seven transmembrane segments and is expressed in highest levels in fetal and adult brain and lung. |
| UniProt Protein Function: | SSTR4: Receptor for somatostatin-14. The activity of this receptor is mediated by G proteins which inhibits adenylyl cyclase. It is functionally coupled not only to inhibition of adenylate cyclase, but also to activation of both arachidonate release and mitogen-activated protein (MAP) kinase cascade. Mediates antiproliferative action of somatostatin in tumor cells. Belongs to the G-protein coupled receptor 1 family. |
| UniProt Protein Details: | Protein type:GPCR, family 1; Receptor, GPCR; Membrane protein, multi-pass; Membrane protein, integral Chromosomal Location of Human Ortholog: 20p11.2 Cellular Component: cytoplasm; integral to plasma membrane; neuron projection; plasma membrane Molecular Function:neuropeptide binding; somatostatin receptor activity Biological Process: arachidonic acid metabolic process; cell migration; forebrain development; G-protein coupled receptor protein signaling pathway; G-protein signaling, coupled to cyclic nucleotide second messenger; negative regulation of cAMP metabolic process; negative regulation of cell proliferation; positive regulation of MAPKKK cascade |
| NCBI Summary: | Somatostatin acts at many sites to inhibit the release of many hormones and other secretory proteins. The biologic effects of somatostatin are probably mediated by a family of G protein-coupled receptors that are expressed in a tissue-specific manner. SSTR4 is a member of the superfamily of receptors having seven transmembrane segments and is expressed in highest levels in fetal and adult brain and lung. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P31391 |
| NCBI GenInfo Identifier: | 206729897 |
| NCBI Gene ID: | 6754 |
| NCBI Accession: | P31391.2 |
| UniProt Secondary Accession: | P31391,Q17RM1, Q17RM3, Q9UIY1, |
| UniProt Related Accession: | P31391 |
| Molecular Weight: | 42,003 Da |
| NCBI Full Name: | Somatostatin receptor type 4 |
| NCBI Synonym Full Names: | somatostatin receptor 4 |
| NCBI Official Symbol: | SSTR4 |
| NCBI Official Synonym Symbols: | SS4R; SS4-R; SS-4-R |
| NCBI Protein Information: | somatostatin receptor type 4 |
| UniProt Protein Name: | Somatostatin receptor type 4 |
| Protein Family: | Somatostatin receptor |
| UniProt Gene Name: | SSTR4 |
| UniProt Entry Name: | SSR4_HUMAN |
 | Western blot analysis of extracts of various cell lines, using SSTR4 antibody (CAB6988) at 1:1000 dilution._Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution._Lysates/proteins: 25ug per lane._Blocking buffer: 3% nonfat dry milk in TBST._Detection: ECL Enhanced Kit (RM00021)._Exposure time: 300s. |
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