Anti-SSR1 Antibody (CAB4129)
- SKU:
- CAB4129
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
Frequently bought together:
Description
| 抗体名: | Anti-SSR1 Antibody |
| 抗体コード: | CAB4129 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB |
| 反応性: | Human, Mouse |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 19-207 of human SSR1 (NP_003135.2). |
| 申し込み: | WB |
| 推奨希釈: | WB 1:500 - 1:2000 |
| 反応性: | Human, Mouse |
| ポジティブサンプル: | LO2, HeLa, Jurkat |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 19-207 of human SSR1 (NP_003135.2). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | VLFR GGPR GLLA VAQD LTED EETV EDSI IEDE DDEA EVEE DEPT DLVE DKEE EDVS GEPE ASPS ADTT ILFV KGED FPAN NIVK FLVG FTNK GTED FIVE SLDA SFRY PQDY QFYI QNFT ALPL NTVV PPQR QATF EYSF IPAE PMGG RPFG LVIN LNYK DLNG NVFQ DAVF NQTV TVIE REDG LDGE T |
| 遺伝子ID: | 6745 |
| Uniprot: | P43307 |
| セルラーロケーション: | Endoplasmic reticulum membrane, Single-pass type I membrane protein |
| 計算された分子量: | 29kDa/32kDa |
| 観察された分子量: | 37kDa |
| 同義語: | SSR1, TRAPA |
| バックグラウンド: | The signal sequence receptor (SSR) is a glycosylated endoplasmic reticulum (ER) membrane receptor associated with protein translocation across the ER membrane. The SSR consists of 2 subunits, a 34-kD glycoprotein encoded by this gene and a 22-kD glycoprotein. This gene generates several mRNA species as a result of complex alternative polyadenylation. This gene is unusual in that it utilizes arrays of polyA signal sequences that are mostly non-canonical. Multiple transcript variants encoding different isoforms have been found for this gene. |
| UniProt Protein Function: | SSR1: TRAP proteins are part of a complex whose function is to bind calcium to the ER membrane and thereby regulate the retention of ER resident proteins. May be involved in the recycling of the translocation apparatus after completion of the translocation process or may function as a membrane-bound chaperone facilitating folding of translocated proteins. Belongs to the TRAP-alpha family. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Membrane protein, integral Chromosomal Location of Human Ortholog: 6p24.3 Cellular Component: endoplasmic reticulum; endoplasmic reticulum membrane Molecular Function:protein binding Biological Process: cotranslational protein targeting to membrane; positive regulation of cell proliferation |
| NCBI Summary: | The signal sequence receptor (SSR) is a glycosylated endoplasmic reticulum (ER) membrane receptor associated with protein translocation across the ER membrane. The SSR consists of 2 subunits, a 34-kD glycoprotein encoded by this gene and a 22-kD glycoprotein. This gene generates several mRNA species as a result of complex alternative polyadenylation. This gene is unusual in that it utilizes arrays of polyA signal sequences that are mostly non-canonical. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2014] |
| UniProt Code: | P43307 |
| NCBI GenInfo Identifier: | 22261821 |
| NCBI Gene ID: | 6745 |
| NCBI Accession: | P43307.3 |
| UniProt Secondary Accession: | P43307,Q53GX2, Q53H19, Q5TAM3, Q6IB43, Q8NBH9, Q96IA2 Q9TNQ8, Q9UN49, A8K685, |
| UniProt Related Accession: | P43307 |
| Molecular Weight: | 29,373 Da |
| NCBI Full Name: | Translocon-associated protein subunit alpha |
| NCBI Synonym Full Names: | signal sequence receptor subunit 1 |
| NCBI Official Symbol: | SSR1 |
| NCBI Official Synonym Symbols: | TRAPA |
| NCBI Protein Information: | translocon-associated protein subunit alpha |
| UniProt Protein Name: | Translocon-associated protein subunit alpha |
| UniProt Synonym Protein Names: | Signal sequence receptor subunit alpha; SSR-alpha |
| Protein Family: | SWI/SNF and RSC complexes |
| UniProt Gene Name: | SSR1 |
| UniProt Entry Name: | SSRA_HUMAN |
 | Western blot analysis of extracts of various cell lines, using SSR1 Antibody (CAB4129) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 20s. |
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