Anti-SSPN Antibody (CAB12191)
- SKU:
- CAB12191
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Frequently bought together:
Description
| 抗体名: | Anti-SSPN Antibody |
| 抗体コード: | CAB12191 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB |
| 反応性: | Human, Mouse, Rat |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-60 of human SSPN (NP_005077.2). |
| 申し込み: | WB |
| 推奨希釈: | WB 1:500 - 1:2000 |
| 反応性: | Human, Mouse, Rat |
| ポジティブサンプル: | NIH/3T3, Mouse skeletal muscle, Mouse heart, Mouse brain, Rat heart, Rat brain |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-60 of human SSPN (NP_005077.2). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | MGKN KQPR GQQR QGGP PAAD AAGP DDME PKKG TGAP KECG EEEP RTCC GCRF PLLL ALLQ |
| 遺伝子ID: | 8082 |
| Uniprot: | Q14714 |
| セルラーロケーション: | Cell junction, Cell membrane, Multi-pass membrane protein, postsynaptic cell membrane, sarcolemma, synapse |
| 計算された分子量: | 14kDa/15kDa/26kDa |
| 観察された分子量: | 27kDa |
| 同義語: | SSPN, DAGA5, KRAG, NSPN, SPN1, SPN2, sarcospan |
| バックグラウンド: | This gene encodes a member of the dystrophin-glycoprotein complex (DGC). The DGC spans the sarcolemma and is comprised of dystrophin, syntrophin, alpha- and beta-dystroglycans and sarcoglycans. The DGC provides a structural link between the subsarcolemmal cytoskeleton and the extracellular matrix of muscle cells. Two alternatively spliced transcript variants that encode different protein isoforms have been described. |
| UniProt Protein Function: | SSPN: Component of the dystrophin-glycoprotein complex (DGC), a complex that spans the muscle plasma membrane and forms a link between the F-actin cytoskeleton and the extracellular matrix. Preferentially associates with the sarcoglycan subcomplex of the DGC. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Membrane protein, integral; Membrane protein, multi-pass; Motility/polarity/chemotaxis Chromosomal Location of Human Ortholog: 12p12.1 Cellular Component: transport vesicle Biological Process: cell adhesion; muscle contraction |
| NCBI Summary: | This gene encodes a member of the dystrophin-glycoprotein complex (DGC). The DGC spans the sarcolemma and is comprised of dystrophin, syntrophin, alpha- and beta-dystroglycans and sarcoglycans. The DGC provides a structural link between the subsarcolemmal cytoskeleton and the extracellular matrix of muscle cells. Two alternatively spliced transcript variants that encode different protein isoforms have been described. [provided by RefSeq, Oct 2008] |
| UniProt Code: | Q14714 |
| NCBI GenInfo Identifier: | 13431900 |
| NCBI Gene ID: | 8082 |
| NCBI Accession: | Q14714.3 |
| UniProt Secondary Accession: | Q14714,B3KS67, |
| UniProt Related Accession: | Q14714 |
| Molecular Weight: | 27kDa |
| NCBI Full Name: | Sarcospan |
| NCBI Synonym Full Names: | sarcospan |
| NCBI Official Symbol: | SSPN |
| NCBI Official Synonym Symbols: | KRAG; NSPN; SPN1; SPN2; DAGA5 |
| NCBI Protein Information: | sarcospan |
| UniProt Protein Name: | Sarcospan |
| UniProt Synonym Protein Names: | K-ras oncogene-associated protein; Kirsten-ras-associated protein |
| Protein Family: | Sarcospan |
| UniProt Gene Name: | SSPN |
 | Western blot analysis of extracts of various cell lines, using SSPN antibody (CAB12191) at 1:3000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s. |
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