Anti-SS18 Antibody (CAB6990)
- SKU:
- CAB6990
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Epigenetics and Nuclear Signaling
Frequently bought together:
Description
抗体名: | Anti-SS18 Antibody |
抗体コード: | CAB6990 |
抗体サイズ: | 20uL, 50uL, 100uL |
申し込み: | WB IHC IF |
反応性: | Human |
宿主種: | Rabbit |
免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-240 of human SS18 (NP_001007560.1). |
申し込み: | WB IHC IF |
推奨希釈: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 IF 1:50 - 1:100 |
反応性: | Human |
ポジティブサンプル: | MCF7, Jurkat |
免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-240 of human SS18 (NP_001007560.1). |
精製方法: | Affinity purification |
ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
アイソタイプ: | IgG |
順序: | MSVA FAAP RQRG KGEI TPAA IQKM LDDN NHLI QCIM DSQN KGKT SECS QYQQ MLHT NLVY LATI ADSN QNMQ SLLP APPT QNMP MGPG GMNQ SGPP PPPR SHNM PSDG MVGG GPPA PHMQ NQMN GQMP GPNH MPMQ GPGP NQLN MTNS SMNM PSSS HGSM GGYN HSVP SSQS MPVQ NQMT MSQG QPMG NYGP RPNM SMQP NQGP MMHQ QPPS QQYN MPQG GGQH YQGQ QPPM GMMG QVNQ |
遺伝子ID: | 6760 |
Uniprot: | Q15532 |
セルラーロケーション: | Nucleus |
計算された分子量: | 42kDa/45kDa |
観察された分子量: | 60kDa |
同義語: | SS18, SSXT, SYT |
バックグラウンド: |
UniProt Protein Function: | SS18: Appears to function synergistically with RBM14 as a transcriptional coactivator. Isoform 1 and isoform 2 function in nuclear receptor coactivation. Isoform 1 and isoform 2 function in general transcriptional coactivation. A chromosomal aberration involving SS18 may be a cause of synovial sarcoma. Translocation t(X;18)(p11.2;q11.2). The translocation is specifically found in more than 80% of synovial sarcoma. The fusion products SSXT-SSX1 or SSXT-SSX2 are probably responsible for transforming activity. Heterogeneity in the position of the breakpoint can occur (low frequency). Belongs to the SS18 family. 2 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:Oncoprotein; Transcription, coactivator/corepressor; Nuclear receptor co-regulator Chromosomal Location of Human Ortholog: 18q11.2 Cellular Component: cytoplasmic microtubule; nucleus Molecular Function:protein binding; ligand-dependent nuclear receptor transcription coactivator activity Biological Process: response to drug; transcription, DNA-dependent; cell morphogenesis; ephrin receptor signaling pathway; positive regulation of transcription from RNA polymerase II promoter; microtubule cytoskeleton organization and biogenesis |
UniProt Code: | Q15532 |
NCBI GenInfo Identifier: | 20141795 |
NCBI Gene ID: | 6760 |
NCBI Accession: | Q15532.3 |
UniProt Secondary Accession: | Q15532,Q16404, Q4VAX1, Q9BXC6, B0YJ95, |
UniProt Related Accession: | Q15532 |
Molecular Weight: | 418 |
NCBI Full Name: | Protein SSXT |
NCBI Synonym Full Names: | synovial sarcoma translocation, chromosome 18 |
NCBI Official Symbol: | SS18 |
NCBI Official Synonym Symbols: | SYT; SSXT |
NCBI Protein Information: | protein SSXT; synovial sarcoma, translocated to X chromosome; synovial sarcoma translocated to X chromosome protein |
UniProt Protein Name: | Protein SSXT |
UniProt Synonym Protein Names: | Protein SYT; Synovial sarcoma translocated to X chromosome protein |
Protein Family: | SS18-like protein |
UniProt Gene Name: | SS18 |
UniProt Entry Name: | SSXT_HUMAN |
View AllClose