Anti-SRSF7 Antibody (CAB16738)
- SKU:
- CAB16738
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Epigenetics and Nuclear Signaling
Frequently bought together:
Description
| 抗体名: | Anti-SRSF7 Antibody |
| 抗体コード: | CAB16738 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB IHC IF |
| 反応性: | Human, Mouse, Rat |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 60-120 of human SRSF7 (NP_001026854). |
| 申し込み: | WB IHC IF |
| 推奨希釈: | WB 1:500 - 1:1000 IHC 1:50 - 1:100 IF 1:50 - 1:100 |
| 反応性: | Human, Mouse, Rat |
| ポジティブサンプル: | HeLa, Mouse brain, Mouse kidney, Rat brain, Rat kidney |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 60-120 of human SRSF7 (NP_001026854). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | AEDA VRGL DGKV ICGS RVRV ELST GMPR RSRF DRPP ARRP FDPN DRCY ECGE KGHY AYDC H |
| 遺伝子ID: | 6432 |
| Uniprot: | Q16629 |
| セルラーロケーション: | Cytoplasm, Nucleus |
| 計算された分子量: | 15kDa/26kDa/27kDa |
| 観察された分子量: | 35KDa |
| 同義語: | SRSF7, 9G8, AAG3, SFRS7 |
| バックグラウンド: | The protein encoded by this gene is a member of the serine/arginine (SR)-rich family of pre-mRNA splicing factors, which constitute part of the spliceosome. Each of these factors contains an RNA recognition motif (RRM) for binding RNA and an RS domain for binding other proteins. The RS domain is rich in serine and arginine residues and facilitates interaction between different SR splicing factors. In addition to being critical for mRNA splicing, the SR proteins have also been shown to be involved in mRNA export from the nucleus and in translation. Two transcript variants encoding different isoforms have been found for this gene. |
| UniProt Protein Function: | SFRS7: Required for pre-mRNA splicing. Can also modulate alternative splicing in vitro. Represses the splicing of MAPT/Tau exon 10. Belongs to the splicing factor SR family. 3 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:RNA splicing; Spliceosome; RNA-binding Chromosomal Location of Human Ortholog: 2p22.1 Cellular Component: nucleoplasm; cytoplasm; nucleus Molecular Function:protein binding; zinc ion binding; nucleotide binding Biological Process: nuclear mRNA splicing, via spliceosome; transcription from RNA polymerase II promoter; mRNA export from nucleus; negative regulation of nuclear mRNA splicing, via spliceosome; RNA splicing; gene expression; mRNA 3'-end processing; mRNA processing; termination of RNA polymerase II transcription |
| NCBI Summary: | The protein encoded by this gene is a member of the serine/arginine (SR)-rich family of pre-mRNA splicing factors, which constitute part of the spliceosome. Each of these factors contains an RNA recognition motif (RRM) for binding RNA and an RS domain for binding other proteins. The RS domain is rich in serine and arginine residues and facilitates interaction between different SR splicing factors. In addition to being critical for mRNA splicing, the SR proteins have also been shown to be involved in mRNA export from the nucleus and in translation. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2010] |
| UniProt Code: | Q16629 |
| NCBI GenInfo Identifier: | 3929380 |
| NCBI Gene ID: | 6432 |
| NCBI Accession: | Q16629.1 |
| UniProt Secondary Accession: | Q16629,Q564D3, B4DLU6, G5E9M3, |
| UniProt Related Accession: | Q16629 |
| Molecular Weight: | 238 |
| NCBI Full Name: | Serine/arginine-rich splicing factor 7 |
| NCBI Synonym Full Names: | serine/arginine-rich splicing factor 7 |
| NCBI Official Symbol: | SRSF7 |
| NCBI Official Synonym Symbols: | 9G8; AAG3; SFRS7 |
| NCBI Protein Information: | serine/arginine-rich splicing factor 7; splicing factor 9G8; SR splicing factor 7; aging-associated protein 3; splicing factor, arginine/serine-rich 7, 35kDa |
| UniProt Protein Name: | Serine/arginine-rich splicing factor 7 |
| UniProt Synonym Protein Names: | Splicing factor 9G8; Splicing factor, arginine/serine-rich 7 |
| Protein Family: | Serine/arginine-rich splicing factor |
| UniProt Gene Name: | SRSF7 |
| UniProt Entry Name: | SRSF7_HUMAN |
 | Western blot analysis of extracts of various cell lines, using SRSF7 Rabbit pAb (CAB16738) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 60s. |
 | Immunohistochemistry of paraffin-embedded mouse testis using SRSF7 Rabbit pAb (CAB16738) at dilution of 1:100 (40x lens). |
 | Immunohistochemistry of paraffin-embedded human esophageal using SRSF7 Rabbit pAb (CAB16738) at dilution of 1:100 (40x lens). |
 | Immunofluorescence analysis of U-2 OS cells using SRSF7 antibody (CAB16738) at dilution of 1:100. Blue: DAPI for nuclear staining. |
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