Anti-SRRT Antibody (CAB8219)
- SKU:
- CAB8219
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
Frequently bought together:
Description
抗体名: | Anti-SRRT Antibody |
抗体コード: | CAB8219 |
抗体サイズ: | 20uL, 50uL, 100uL |
申し込み: | IHC |
反応性: | Human, Mouse, Rat |
宿主種: | Rabbit |
免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 623-872 of human SRRT (NP_001122325.1). |
申し込み: | IHC |
推奨希釈: | IHC 1:50 - 1:200 |
反応性: | Human, Mouse, Rat |
ポジティブサンプル: |
免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 623-872 of human SRRT (NP_001122325.1). |
精製方法: | Affinity purification |
ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
アイソタイプ: | IgG |
順序: | DYYN TCEY PNED EMPN RCGI IHVR GPMP PNRI SHGE VLEW QKTF EEKL TPLL SVRE SLSE EEAQ KMGR KDPE QEVE KFVT SNTQ ELGK DKWL CPLS GKKF KGPE FVRK HIFN KHAE KIEE VKKE VAFF NNFL TDAK RPAL PEIK PAQP PGPA QSLT PGLP YPHQ TPQG LMPY GQPR PPIL GYGA GAVR PAVP TGGP PYPH APYG AGRG NYDA FRGQ GGYP GKPR NRMV RGDP RAIV EYRD LDAP DDVD FF |
遺伝子ID: | 51593 |
Uniprot: | Q9BXP5 |
セルラーロケーション: | Cytoplasm, Nucleus, nucleoplasm |
計算された分子量: | 96kDa/100kDa |
観察された分子量: | Refer to figures |
同義語: | SRRT, ARS2, ASR2, serrate |
バックグラウンド: |
UniProt Protein Function: | SRRT: Acts as a mediator between the cap-binding complex (CBC) and the primary microRNAs (miRNAs) processing machinery during cell proliferation. Contributes to the stability and delivery of capped primary miRNA transcripts to the primary miRNA processing complex containing DGCR8 and DROSHA, thereby playing a role in RNA-mediated gene silencing (RNAi) by miRNAs. Binds capped RNAs (m7GpppG-capped RNA); however interaction is probably mediated via its interaction with NCBP1/CBP80 component of the CBC complex. Involved in cell cycle progression at S phase. Does not directly confer arsenite resistance but rather modulates arsenic sensitivity. Independently of its activity on miRNAs, necessary and sufficient to promote neural stem cell self-renewal. Does so by directly binding SOX2 promoter and positively regulating its transcription. Belongs to the ARS2 family. 5 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:RNA-binding; RNA processing; Spliceosome Chromosomal Location of Human Ortholog: 7q21 Cellular Component: cytoplasm; nucleoplasm Molecular Function:DNA binding; protein binding Biological Process: cell proliferation; nuclear mRNA splicing, via spliceosome; primary microRNA processing; regulation of transcription, DNA-dependent; snRNA transcription from RNA polymerase II promoter |
UniProt Code: | Q9BXP5 |
NCBI GenInfo Identifier: | 20137457 |
NCBI Gene ID: | 51593 |
NCBI Accession: | Q9BXP5.1 |
UniProt Secondary Accession: | Q9BXP5,O95808, Q32MI4, Q6NT74, Q8TDQ5, Q9BWP6, Q9BXP4 A4D2E5, A4D2E6, A6NK22, B4DJL4, B4DZA6, |
UniProt Related Accession: | Q9BXP5 |
Molecular Weight: | 96,222 Da |
NCBI Full Name: | Serrate RNA effector molecule homolog |
NCBI Synonym Full Names: | serrate, RNA effector molecule |
NCBI Official Symbol: | SRRT |
NCBI Official Synonym Symbols: | ARS2; ASR2; serrate |
NCBI Protein Information: | serrate RNA effector molecule homolog |
UniProt Protein Name: | Serrate RNA effector molecule homolog |
UniProt Synonym Protein Names: | Arsenite-resistance protein 2 |
UniProt Gene Name: | SRRT |
UniProt Entry Name: | SRRT_HUMAN |
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