Anti-SRI Antibody (CAB19921)[KO Validated]
![Anti-SRI Antibody (CAB19921)[KO Validated]](https://cdn11.bigcommerce.com/s-d5atsu6k01/images/stencil/608x608/products/26354/26202/anti-sri-antibody-cab19921ko-validated__82182__18121.1645806464.jpg?c=1 "Anti-SRI Antibody (CAB19921)[KO Validated]")
- SKU:
- CAB19921
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
![Anti-SRI Antibody (CAB19921)[KO Validated]](https://cdn11.bigcommerce.com/s-d5atsu6k01/images/stencil/1280x1280/products/26354/26202/anti-sri-antibody-cab19921ko-validated__82182__18121.1645806464.jpg?c=1&imbypass=on "Anti-SRI Antibody (CAB19921)[KO Validated]")
Description
| 抗体名: | Anti-SRI Antibody [KO Validated] |
| 抗体コード: | CAB19921 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB IHC IF |
| 反応性: | Human, Mouse, Rat |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant protein of human SRI. |
| 申し込み: | WB IHC IF |
| 推奨希釈: | WB 1:500 - 1:2000 IHC 1:50 - 1:100 IF 1:50 - 1:100 |
| 反応性: | Human, Mouse, Rat |
| ポジティブサンプル: | HeLa |
| 免疫原: | Recombinant protein of human SRI. |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | Email for sequence |
| 遺伝子ID: | 6717 |
| Uniprot: | P30626 |
| セルラーロケーション: | Cytoplasm, Cytoplasmic side, Peripheral membrane protein, Sarcoplasmic reticulum membrane |
| 計算された分子量: | 20kDa/21kDa |
| 観察された分子量: | 18KDa |
![Anti-SRI Antibody [KO Validated] (CAB19921)](https://cdn11.bigcommerce.com/s-h68l9z2lnx/product_images/c/556/A19921_1__11742.jpg) | Western blot analysis of extracts from normal (control) and SRI knockout (KO) HeLa cells, using SRI antibody (CAB19921) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 1s. |
| 同義語: | SRI, CP-22, CP22, SCN, V19, sorcin |
| バックグラウンド: | This gene encodes a calcium-binding protein with multiple E-F hand domains that relocates from the cytoplasm to the sarcoplasmic reticulum in response to elevated calcium levels. In addition to regulating intracellular calcium homeostasis it also modulates excitation-contraction coupling in the heart. Alternative splicing results in multiple transcript variants encoding distinct proteins. Multiple pseudogenes exist for this gene. |
| UniProt Protein Function: | SRI: Calcium-binding protein that modulates excitation- contraction coupling in the heart. Contributes to calcium homeostasis in the heart sarcoplasmic reticulum. Modulates the activity of RYR2 calcium channels. |
| UniProt Protein Details: | Protein type:Calcium-binding Chromosomal Location of Human Ortholog: 7q21.1 Cellular Component: nucleoplasm; endoplasmic reticulum membrane; sarcoplasmic reticulum membrane; smooth endoplasmic reticulum; membrane; mitochondrion; sarcoplasmic reticulum; T-tubule; cytoplasm; nerve terminal; cytosol; Z disc Molecular Function:protein binding; protease binding; protein heterodimerization activity; calcium channel regulator activity; calcium-dependent cysteine-type endopeptidase activity; calcium ion binding; receptor binding Biological Process: regulation of action potential; cytoplasmic sequestering of transcription factor; muscle development; negative regulation of heart rate; heart development; regulation of striated muscle contraction; regulation of calcium ion transport; proteolysis; signal transduction; regulation of heart contraction; transport; calcium ion transport; positive regulation of release of sequestered calcium ion into cytosol; intracellular sequestering of iron ion |
| NCBI Summary: | This gene encodes a calcium-binding protein with multiple E-F hand domains that relocates from the cytoplasm to the sarcoplasmic reticulum in response to elevated calcium levels. In addition to regulating intracellular calcium homeostasis it also modulates excitation-contraction coupling in the heart. Alternative splicing results in multiple transcript variants encoding distinct proteins. Multiple pseudogenes exist for this gene. [provided by RefSeq, Mar 2012] |
| UniProt Code: | P30626 |
| NCBI GenInfo Identifier: | 267021 |
| NCBI Gene ID: | 6717 |
| NCBI Accession: | P30626.1 |
| UniProt Secondary Accession: | P30626,A8MTH6, B4DKK2, D6W5Q0, |
| UniProt Related Accession: | P30626 |
| Molecular Weight: | 198 |
| NCBI Full Name: | Sorcin |
| NCBI Synonym Full Names: | sorcin |
| NCBI Official Symbol: | SRI |
| NCBI Official Synonym Symbols: | SCN; V19; CP22; CP-22 |
| NCBI Protein Information: | sorcin; H_RG167B05.1; 22 kDa protein; calcium binding protein amplified in mutlidrug-resistant cells |
| UniProt Protein Name: | Sorcin |
| UniProt Synonym Protein Names: | 22 kDa protein; CP-22; CP22; V19 |
| UniProt Gene Name: | SRI |
| UniProt Entry Name: | SORCN_HUMAN |