Anti-SQS/FDFT1 Antibody (CAB6229)
- SKU:
- CAB6229
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Metabolism
Frequently bought together:
Description
抗体名: | Anti-SQS/FDFT1 Antibody |
抗体コード: | CAB6229 |
抗体サイズ: | 20uL, 50uL, 100uL |
申し込み: | WB IHC IF |
反応性: | Human, Mouse, Rat |
宿主種: | Rabbit |
免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-260 of human SQS/FDFT1 (NP_004453.3). |
申し込み: | WB IHC IF |
推奨希釈: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 IF 1:50 - 1:200 |
反応性: | Human, Mouse, Rat |
ポジティブサンプル: | 22Rv1, HT-29, Jurkat, MCF7, HepG2, Mouse liver, Rat liver |
免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-260 of human SQS/FDFT1 (NP_004453.3). |
精製方法: | Affinity purification |
ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
アイソタイプ: | IgG |
順序: | MEFV KCLG HPEE FYNL VRFR IGGK RKVM PKMD QDSL SSSL KTCY KYLN QTSR SFAA VIQA LDGE MRNA VCIF YLVL RALD TLED DMTI SVEK KVPL LHNF HSFL YQPD WRFM ESKE KDRQ VLED FPTI SLEF RNLA EKYQ TVIA DICR RMGI GMAE FLDK HVTS EQEW DKYC HYVA GLVG IGLS RLFS ASEF EDPL VGED TERA NSMG LFLQ KTNI IRDY LEDQ QGGR EFWP QEVW SRYV KKLG DFAK PENI DLAV QCLN |
遺伝子ID: | 2222 |
Uniprot: | P37268 |
セルラーロケーション: | Endoplasmic reticulum membrane, Multi-pass membrane protein |
計算された分子量: | 35kDa/38kDa/40kDa/43kDa/48kDa |
観察された分子量: | 48kDa |
同義語: | FDFT1, DGPT, ERG9, SQS, SS |
バックグラウンド: | This gene encodes a membrane-associated enzyme located at a branch point in the mevalonate pathway. The encoded protein is the first specific enzyme in cholesterol biosynthesis, catalyzing the dimerization of two molecules of farnesyl diphosphate in a two-step reaction to form squalene. |
UniProt Protein Function: | FDFT1: a membrane-associated enzyme located at a branch point in the mevalonate pathway. The encoded protein is the first specific enzyme in cholesterol biosynthesis, catalyzing the dimerization of two molecules of farnesyl diphosphate in a two-step reaction to form squalene. [provided by RefSeq, Jul 2008] |
UniProt Protein Details: | Protein type:Oxidoreductase; EC 2.5.1.21; Endoplasmic reticulum; Lipid Metabolism - steroid biosynthesis; Membrane protein, integral; Transferase; Membrane protein, multi-pass Chromosomal Location of Human Ortholog: 8p23.1-p22 Cellular Component: endoplasmic reticulum; endoplasmic reticulum membrane Molecular Function:farnesyl-diphosphate farnesyltransferase activity Biological Process: cholesterol biosynthetic process; steroid biosynthetic process |
NCBI Summary: | This gene encodes a membrane-associated enzyme located at a branch point in the mevalonate pathway. The encoded protein is the first specific enzyme in cholesterol biosynthesis, catalyzing the dimerization of two molecules of farnesyl diphosphate in a two-step reaction to form squalene. [provided by RefSeq, Jul 2008] |
UniProt Code: | P37268 |
NCBI GenInfo Identifier: | 585126 |
NCBI Gene ID: | 2222 |
NCBI Accession: | P37268.1 |
UniProt Secondary Accession: | P37268,Q96GT0, B3KQ95, B4DJE5, B4DT56, B7Z1J3, |
UniProt Related Accession: | P37268 |
Molecular Weight: | 43,060 Da |
NCBI Full Name: | Squalene synthase |
NCBI Synonym Full Names: | farnesyl-diphosphate farnesyltransferase 1 |
NCBI Official Symbol: | FDFT1 |
NCBI Official Synonym Symbols: | SS; SQS; DGPT; ERG9 |
NCBI Protein Information: | squalene synthase |
UniProt Protein Name: | Squalene synthase |
UniProt Synonym Protein Names: | FPP:FPP farnesyltransferase; Farnesyl-diphosphate farnesyltransferase |
UniProt Gene Name: | FDFT1 |
UniProt Entry Name: | FDFT_HUMAN |
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