Anti-SPPL2A Antibody (CAB15539)
- SKU:
- CAB15539
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Frequently bought together:
Description
抗体名: | Anti-SPPL2A Antibody |
抗体コード: | CAB15539 |
抗体サイズ: | 20uL, 50uL, 100uL |
申し込み: | WB IHC |
反応性: | Human, Mouse, Rat |
宿主種: | Rabbit |
免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 421-520 of human SPPL2A (NP_116191.2). |
申し込み: | WB IHC |
推奨希釈: | WB 1:200 - 1:2000 IHC 1:50 - 1:200 |
反応性: | Human, Mouse, Rat |
ポジティブサンプル: | HeLa, Jurkat, Mouse brain, Rat small intestine |
免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 421-520 of human SPPL2A (NP_116191.2). |
精製方法: | Affinity purification |
ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
アイソタイプ: | IgG |
順序: | AYCR RFDV QTGS SYIY YVSS TVAY AIGM ILTF VVLV LMKK GQPA LLYL VPCT LITA SVVA WRRK EMKK FWKG NSYQ MMDH LDCA TNEE NPVI SGEQ IVQQ |
遺伝子ID: | 84888 |
Uniprot: | Q8TCT8 |
セルラーロケーション: | Late endosome membrane, Lumenal side, Lysosome membrane, Membrane, Multi-pass membrane protein |
計算された分子量: | 58kDa |
観察された分子量: | 57kDa |
同義語: | SPPL2A, IMP3, PSL2 |
バックグラウンド: | This gene encodes a member of the GXGD family of aspartic proteases, which are transmembrane proteins with two conserved catalytic motifs localized within the membrane-spanning regions, as well as a member of the signal peptide peptidase-like protease (SPPL) family. This protein is expressed in all major adult human tissues and localizes to late endosomal compartments and lysosomal membranes. A pseudogene of this gene also lies on chromosome 15. |
UniProt Protein Function: | SPPL2A: Intramembrane-cleaving aspartic protease (I-CLiP) that cleaves type II membrane signal peptides in the hydrophobic plane of the membrane. Functions in FASLG, ITM2B and TNF processing. Catalyzes the intramembrane cleavage of the anchored fragment of shed TNF-alpha (TNF), which promotes the release of the intracellular domain (ICD) for signaling to the nucleus. Also responsible for the intramembrane cleavage of Fas antigen ligand FASLG, which promotes the release of the intracellular FasL domain (FasL ICD). May play a role in the regulation of innate and adaptive immunity. Belongs to the peptidase A22B family. |
UniProt Protein Details: | Protein type:Cancer Testis Antigen (CTA); EC 3.4.23.-; Membrane protein, multi-pass; Protease; Membrane protein, integral Chromosomal Location of Human Ortholog: 15q21.2 Cellular Component: intracellular membrane-bound organelle; late endosome; lysosomal membrane; membrane; plasma membrane Molecular Function:aspartic endopeptidase activity, intramembrane cleaving; protein binding; protein homodimerization activity Biological Process: membrane protein ectodomain proteolysis; membrane protein intracellular domain proteolysis; membrane protein proteolysis; regulation of immune response; signal peptide processing |
NCBI Summary: | This gene encodes a member of the GXGD family of aspartic proteases, which are transmembrane proteins with two conserved catalytic motifs localized within the membrane-spanning regions, as well as a member of the signal peptide peptidase-like protease (SPPL) family. This protein is expressed in all major adult human tissues and localizes to late endosomal compartments and lysosomal membranes. A pseudogene of this gene also lies on chromosome 15. [provided by RefSeq, Feb 2012] |
UniProt Code: | Q8TCT8 |
NCBI GenInfo Identifier: | 25008981 |
NCBI Gene ID: | 84888 |
NCBI Accession: | Q8TCT8.2 |
UniProt Secondary Accession: | Q8TCT8,Q8TAW1, Q96SZ8, B2RDS0, |
UniProt Related Accession: | Q8TCT8 |
Molecular Weight: | 58,143 Da |
NCBI Full Name: | Signal peptide peptidase-like 2A |
NCBI Synonym Full Names: | signal peptide peptidase like 2A |
NCBI Official Symbol: | SPPL2A |
NCBI Official Synonym Symbols: | IMP3; PSL2 |
NCBI Protein Information: | signal peptide peptidase-like 2A |
UniProt Protein Name: | Signal peptide peptidase-like 2A |
UniProt Synonym Protein Names: | Intramembrane protease 3 |
Protein Family: | Signal peptide peptidase |
UniProt Gene Name: | SPPL2A |
UniProt Entry Name: | SPP2A_HUMAN |
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