Anti-SPO11 Antibody (CAB9109)
- SKU:
- CAB9109
- Product type:
- Antibody
- Application:
- WB
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
Frequently bought together:
Description
| 抗体名: | Anti-SPO11 Antibody |
| 抗体コード: | CAB9109 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB |
| 反応性: | Rat |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 269-358 of human SPO11 (NP_937998.1). |
| 申し込み: | WB |
| 推奨希釈: | WB 1:200 - 1:2000 |
| 反応性: | Rat |
| ポジティブサンプル: |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 269-358 of human SPO11 (NP_937998.1). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | AIRW LGLL PSDL KRLN VPKD SLIP LTKR DQMK LDSI LRRP YVTC QPFW RKEM EIMA DSKM KAEI QALT FLSS DYLS RVYL PNKL KFGG WI |
| 遺伝子ID: | 23626 |
| Uniprot: | Q9Y5K1 |
| セルラーロケーション: | Nucleus |
| 計算された分子量: | 40kDa/44kDa |
| 観察された分子量: | Refer to figures |
| 同義語: | SPO11, CT35, SPATA43, TOPVIA |
| バックグラウンド: | Meiotic recombination and chromosome segregation require the formation of double-strand breaks (DSBs) in paired chromosome homologs. During meiosis in yeast, a meiotic recombination protein is covalently-linked to the 5' end of DSBs and is essential for the formation of DSBs. The protein encoded by this gene is similar in sequence and conserved features to the yeast meiotic recombination protein. The encoded protein belongs to the TOP6A protein family. Several transcript variants encoding different isoforms have been found for this gene, but the full-length nature of only two of them have been described. |
| UniProt Protein Function: | SPO11: Required for meiotic recombination. Mediates DNA cleavage that forms the double-strand breaks (DSB) that initiate meiotic recombination. Belongs to the TOP6A family. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Cell cycle regulation; Cancer Testis Antigen (CTA); Cell development/differentiation Chromosomal Location of Human Ortholog: 20q13.31 Molecular Function:protein binding Biological Process: female gamete generation; spermatogenesis |
| NCBI Summary: | Meiotic recombination and chromosome segregation require the formation of double-strand breaks (DSBs) in paired chromosome homologs. During meiosis in yeast, a meiotic recombination protein is covalently-linked to the 5' end of DSBs and is essential for the formation of DSBs. The protein encoded by this gene is similar in sequence and conserved features to the yeast meiotic recombination protein. The encoded protein belongs to the TOP6A protein family. Several transcript variants encoding different isoforms have been found for this gene, but the full-length nature of only two of them have been described. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q9Y5K1 |
| NCBI GenInfo Identifier: | 7674367 |
| NCBI Gene ID: | 23626 |
| NCBI Accession: | Q9Y5K1.1 |
| UniProt Secondary Accession: | Q9Y5K1,Q5TCI1, Q8N4V0, Q9NQM7, Q9NQM8, |
| UniProt Related Accession: | Q9Y5K1 |
| Molecular Weight: | 40,364 Da |
| NCBI Full Name: | Meiotic recombination protein SPO11 |
| NCBI Synonym Full Names: | SPO11, initiator of meiotic double stranded breaks |
| NCBI Official Symbol: | SPO11 |
| NCBI Official Synonym Symbols: | CT35; TOPVIA; SPATA43 |
| NCBI Protein Information: | meiotic recombination protein SPO11 |
| UniProt Protein Name: | Meiotic recombination protein SPO11 |
| UniProt Synonym Protein Names: | Cancer/testis antigen 35; CT35 |
| Protein Family: | Meiosis-specific protein |
| UniProt Gene Name: | SPO11 |
| UniProt Entry Name: | SPO11_HUMAN |
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