Anti-SPN Antibody (CAB6412)
- SKU:
- CAB6412
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Frequently bought together:
Description
| 抗体名: | Anti-SPN Antibody |
| 抗体コード: | CAB6412 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB IHC |
| 反応性: | Human, Mouse |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 276-400 of human SPN (NP_003114.1). |
| 申し込み: | WB IHC |
| 推奨希釈: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 |
| 反応性: | Human, Mouse |
| ポジティブサンプル: | THP-1 |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 276-400 of human SPN (NP_003114.1). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | LWRR RQKR RTGA LVLS RGGK RNGV VDAW AGPA QVPE EGAV TVTV GGSG GDKG SGFP DGEG SSRR PTLT TFFG RRKS RQGS LAME ELKS GSGP SLKG EEEP LVAS EDGA VDAP APDE PEGG DGAA P |
| 遺伝子ID: | 6693 |
| Uniprot: | P16150 |
| セルラーロケーション: | Membrane, Single-pass type I membrane protein |
| 計算された分子量: | 40kDa |
| 観察された分子量: | 130kDa |
| 同義語: | SPN, CD43, GALGP, GPL115, LSN |
| バックグラウンド: | The protein encoded by this gene is a major sialoglycoprotein found on the surface of thymocytes, T lymphocytes, monocytes, granulocytes, and some B lymphocytes. It may be part of a physiologic ligand-receptor complex involved in T-cell activation. During T-cell activation, this protein is actively removed from the T-cell-APC (antigen-presenting cell) contact site, suggesting a negative regulatory role in adaptive immune response. |
| UniProt Protein Function: | sialophorin: One of the major glycoproteins of thymocytes and T lymphocytes. Plays a role in the physicochemical properties of the T-cell surface and in lectin binding. Presents carbohydrate ligands to selectins. Has an extended rodlike structure that could protrude above the glycocalyx of the cell and allow multiple glycan chains to be accessible for binding. Is a counter-receptor for SN/Siglec-1. During T-cell activation is actively removed from the T-cell-APC (antigen-presenting cell) contact site thus suggesting a negative regulatory role in adaptive immune response. Interacts with HIPK2 via the cytoplasmic domain. Interacts with RDX. Cell surface of thymocytes, T-lymphocytes, neutrophils, plasma cells and myelomas. |
| UniProt Protein Details: | Protein type:Cell surface; Membrane protein, integral Chromosomal Location of Human Ortholog: 16p11.2 Cellular Component: extracellular space; cell surface; membrane; integral to plasma membrane; plasma membrane; basement membrane; uropod; external side of plasma membrane Molecular Function:protein binding; transmembrane receptor activity Biological Process: positive regulation of tumor necrosis factor biosynthetic process; regulation of defense response to virus; establishment and/or maintenance of cell polarity; negative regulation of cell adhesion; chemotaxis; signal transduction; negative thymic T cell selection; negative regulation of T cell proliferation; cell surface receptor linked signal transduction; response to protozoan; T cell costimulation; defense response to bacterium; cellular defense response; positive regulation of T cell proliferation; immune response; positive regulation of protein amino acid phosphorylation; blood coagulation; negative regulation of type IV hypersensitivity; leukocyte migration |
| NCBI Summary: | The protein encoded by this gene is a major sialoglycoprotein found on the surface of thymocytes, T lymphocytes, monocytes, granulocytes, and some B lymphocytes. It may be part of a physiologic ligand-receptor complex involved in T-cell activation. During T-cell activation, this protein is actively removed from the T-cell-APC (antigen-presenting cell) contact site, suggesting a negative regulatory role in adaptive immune response. [provided by RefSeq, Sep 2011] |
| UniProt Code: | P16150 |
| NCBI GenInfo Identifier: | 126213 |
| NCBI Gene ID: | 6693 |
| NCBI Accession: | P16150.1 |
| UniProt Secondary Accession: | P16150,A8K9B1, |
| UniProt Related Accession: | P16150 |
| Molecular Weight: | |
| NCBI Full Name: | Leukosialin |
| NCBI Synonym Full Names: | sialophorin |
| NCBI Official Symbol: | SPN |
| NCBI Official Synonym Symbols: | LSN; CD43; GALGP; GPL115 |
| NCBI Protein Information: | leukosialin; galactoglycoprotein; leukocyte sialoglycoprotein; sialophorin (gpL115, leukosialin, CD43) |
| UniProt Protein Name: | Leukosialin |
| UniProt Synonym Protein Names: | Galactoglycoprotein; GALGP; Leukocyte sialoglycoprotein; Sialophorin; CD_antigen: CD43 |
| Protein Family: | Leukosialin |
| UniProt Gene Name: | SPN |
| UniProt Entry Name: | LEUK_HUMAN |
 | Western blot analysis of extracts of THP-1 cells, using SPN antibody (CAB6412) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 60s. |
 | Immunohistochemistry of paraffin-embedded human tonsil using SPN antibody (CAB6412) at dilution of 1:100 (40x lens). |
 | Immunohistochemistry of paraffin-embedded mouse lung using SPN antibody (CAB6412) at dilution of 1:100 (40x lens). |
 | Immunohistochemistry of paraffin-embedded mouse spleen using SPN antibody (CAB6412) at dilution of 1:100 (40x lens). |
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