Anti-SPINK5 Antibody (CAB16489)
- SKU:
- CAB16489
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Frequently bought together:
Description
抗体名: | Anti-SPINK5 Antibody |
抗体コード: | CAB16489 |
抗体サイズ: | 20uL, 50uL, 100uL |
申し込み: | WB |
反応性: | Human |
宿主種: | Rabbit |
免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 895-1094 of human SPINK5 (NP_001121170.1). |
申し込み: | WB |
推奨希釈: | WB 1:500 - 1:2000 |
反応性: | Human |
ポジティブサンプル: |
免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 895-1094 of human SPINK5 (NP_001121170.1). |
精製方法: | Affinity purification |
ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
アイソタイプ: | IgG |
順序: | ERKK KDEE KSSS KPSN NAKD QCRQ VQNE AEDA KFRQ PGRS LASV ARMS TDEC SEFR NYIR NNEL ICPR ENDP VHGA DGKF YTNK CYMC RAVF LTEA LERA KLQE KPSH VRAS QEED SPDS FSSL DSEM CKDY RVLP RIGY LCPK DLKP VCGD DGQT YNNP CMLC HENL IRQT NTHI RSTG KCEE SSTP GTTA ASMP PSDE |
遺伝子ID: | 11005 |
Uniprot: | Q9NQ38 |
セルラーロケーション: | Secreted |
計算された分子量: | 104kDa/120kDa/124kDa |
観察された分子量: | Refer to figures |
同義語: | SPINK5, LEKTI, LETKI, NETS, NS, VAKTI |
バックグラウンド: | This gene encodes a multidomain serine protease inhibitor that contains 15 potential inhibitory domains. The encoded preproprotein is proteolytically processed to generate multiple protein products, which may exhibit unique activities and specificities. These proteins may play a role in skin and hair morphogenesis, as well as anti-inflammatory and antimicrobial protection of mucous epithelia. Mutations in this gene may result in Netherton syndrome, a disorder characterized by ichthyosis, defective cornification, and atopy. This gene is present in a gene cluster on chromosome 5. Alternative splicing results in multiple transcript variants. |
UniProt Protein Function: | SPINK5: Serine protease inhibitor, probably important for the anti-inflammatory and/or antimicrobial protection of mucous epithelia. Contribute to the integrity and protective barrier function of the skin by regulating the activity of defense- activating and desquamation-involved proteases. Inhibits KLK5, it's major target, in a pH-dependent manner. Inhibits KLK7, KLK14 CASP14, and trypsin. Defects in SPINK5 are the cause of Netherton syndrome (NETH). NETH is an autosomal recessive congenital ichthyosis associated with hair shaft abnormalities and anomalies of the immune system. Typical features are ichthyosis linearis circumflexa, ichthyosiform erythroderma, trichorrhexis invaginata (bamboo hair), atopic dermatitis, and hayfever. High postnatal mortality is due to failure to thrive, infections and hypernatremic dehydration. 3 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:Inhibitor; Secreted; Secreted, signal peptide Chromosomal Location of Human Ortholog: 5q32 Cellular Component: cell cortex; cytoplasm; cytosol; endoplasmic reticulum; endoplasmic reticulum membrane; extracellular region; perinuclear region of cytoplasm Molecular Function:serine-type endopeptidase inhibitor activity Biological Process: anagen; epidermal cell differentiation; epithelial cell differentiation; extracellular matrix organization and biogenesis; hair cell differentiation; negative regulation of angiogenesis; negative regulation of immune response; regulation of T cell differentiation Disease: Ige Responsiveness, Atopic; Netherton Syndrome |
NCBI Summary: | This gene encodes a multidomain serine protease inhibitor that contains 15 potential inhibitory domains. The encoded preproprotein is proteolytically processed to generate multiple protein products, which may exhibit unique activities and specificities. These proteins may play a role in skin and hair morphogenesis, as well as anti-inflammatory and antimicrobial protection of mucous epithelia. Mutations in this gene may result in Netherton syndrome, a disorder characterized by ichthyosis, defective cornification, and atopy. This gene is present in a gene cluster on chromosome 5. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2015] |
UniProt Code: | Q9NQ38 |
NCBI GenInfo Identifier: | 212276440 |
NCBI Gene ID: | 11005 |
NCBI Accession: | Q9NQ38.2 |
UniProt Secondary Accession: | Q9NQ38,O75770, Q3LX95, Q3LX96, Q3LX97, Q96PP2, Q96PP3 A8MYE8, B7WPB7, D6REN5, |
UniProt Related Accession: | Q9NQ38 |
Molecular Weight: | 124,076 Da |
NCBI Full Name: | Serine protease inhibitor Kazal-type 5 |
NCBI Synonym Full Names: | serine peptidase inhibitor, Kazal type 5 |
NCBI Official Symbol: | SPINK5 |
NCBI Official Synonym Symbols: | NS; NETS; LEKTI; LETKI; VAKTI |
NCBI Protein Information: | serine protease inhibitor Kazal-type 5 |
UniProt Protein Name: | Serine protease inhibitor Kazal-type 5 |
UniProt Synonym Protein Names: | Lympho-epithelial Kazal-type-related inhibitor; LEKTI |
Protein Family: | Serine protease inhibitor |
UniProt Gene Name: | SPINK5 |
UniProt Entry Name: | ISK5_HUMAN |
View AllClose