Anti-SPG11 Antibody (CAB10326)
- SKU:
- CAB10326
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Frequently bought together:
Description
抗体名: | Anti-SPG11 Antibody |
抗体コード: | CAB10326 |
抗体サイズ: | 20uL, 50uL, 100uL |
申し込み: | WB |
反応性: | Human |
宿主種: | Rabbit |
免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 550-750 of human SPG11 (NP_079413.3). |
申し込み: | WB |
推奨希釈: | WB 1:200 - 1:2000 |
反応性: | Human |
ポジティブサンプル: | U-87MG |
免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 550-750 of human SPG11 (NP_079413.3). |
精製方法: | Affinity purification |
ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
アイソタイプ: | IgG |
順序: | KSKE NLFN PSSK SSVS DQFD HLSS HLYL RNVE ELIP ALDL LCSA IRES YSEP QSKH FSEQ LLNL TLSF LNNQ IKEL FIHT EELD EHLQ KGVN ILTS YINE LRTF MIKF PWKL TDAI DEYD VHEN VPKV KESN IWKK LSFE EVIA SAIL NNKI PEAQ TFFR IDSH SAQK LEEL IGIG LNLV FDNL KKNN IKEA SELL KNMG F |
遺伝子ID: | 80208 |
Uniprot: | Q96JI7 |
セルラーロケーション: | Cytoplasm, Membrane, Multi-pass membrane protein, Nucleus, cytosol |
計算された分子量: | 236kDa/266kDa/278kDa |
観察された分子量: | 280kDa |
同義語: | SPG11, ALS5, CMT2X, KIAA1840, spatacsin |
バックグラウンド: | The protein encoded by this gene is a potential transmembrane protein that is phosphorylated upon DNA damage. Defects in this gene are a cause of spastic paraplegia type 11 (SPG11). Multiple transcript variants encoding different isoforms have been found for this gene. |
UniProt Protein Function: | SPG11: Defects in SPG11 are the cause of spastic paraplegia autosomal recessive type 11 (SPG11). Spastic paraplegia is a neurodegenerative disorder characterized by a slow, gradual, progressive weakness and spasticity of the lower limbs. Rate of progression and the severity of symptoms are quite variable. Initial symptoms may include difficulty with balance, weakness and stiffness in the legs, muscle spasms, and dragging the toes when walking. In some forms of the disorder, bladder symptoms (such as incontinence) may appear, or the weakness and stiffness may spread to other parts of the body. 2 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:Membrane protein, integral; Membrane protein, multi-pass Chromosomal Location of Human Ortholog: 15q21.1 Cellular Component: cytoplasm; cytoplasmic vesicle; cytosol; lysosomal membrane; nucleolus; plasma membrane; synapse Molecular Function:protein binding Biological Process: axon cargo transport; synaptic transmission; synaptic vesicle transport Disease: Amyotrophic Lateral Sclerosis 5, Juvenile; Charcot-marie-tooth Disease, Axonal, Type 2x; Spastic Paraplegia 11, Autosomal Recessive |
NCBI Summary: | The protein encoded by this gene is a potential transmembrane protein that is phosphorylated upon DNA damage. Defects in this gene are a cause of spastic paraplegia type 11 (SPG11). Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2009] |
UniProt Code: | Q96JI7 |
NCBI GenInfo Identifier: | 296452946 |
NCBI Gene ID: | 80208 |
NCBI Accession: | Q96JI7.3 |
UniProt Secondary Accession: | Q96JI7,Q4VC11, Q58G86, Q69YG6, Q6NW01, Q8N270, Q8TBU9 Q9H734, A8KAX9, B9EK60, F5H3N6, |
UniProt Related Accession: | Q96JI7 |
Molecular Weight: | 279kDa |
NCBI Full Name: | Spatacsin |
NCBI Synonym Full Names: | SPG11, spatacsin vesicle trafficking associated |
NCBI Official Symbol: | SPG11 |
NCBI Official Synonym Symbols: | ALS5; CMT2X; KIAA1840 |
NCBI Protein Information: | spatacsin |
UniProt Protein Name: | Spatacsin |
UniProt Synonym Protein Names: | Colorectal carcinoma-associated protein; Spastic paraplegia 11 protein |
Protein Family: | Spatacsin |
UniProt Gene Name: | SPG11 |
View AllClose