Anti-SPAG6 Antibody (CAB3088)
- SKU:
- CAB3088
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
Frequently bought together:
Description
抗体名: | Anti-SPAG6 Antibody |
抗体コード: | CAB3088 |
抗体サイズ: | 20uL, 100uL |
申し込み: | WB |
反応性: | Human |
宿主種: | Rabbit |
免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 180-290 of human SPAG6 (NP_758442.1). |
申し込み: | WB |
推奨希釈: | WB 1:500 - 1:1000 |
反応性: | Human |
ポジティブサンプル: | Jurkat, PC-3 |
免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 180-290 of human SPAG6 (NP_758442.1). |
精製方法: | Affinity purification |
ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
アイソタイプ: | IgG |
順序: | EIAL KRIA ASAL SDIA KHSP ELAQ TVVD AGAV AHLA QMIL NPDA KLKH QILS ALSQ VSKH SVDL AEMV VEAE IFPV VLTC LKDK DEYV KKNA STLI REIA KHTP ELSQ LVV |
遺伝子ID: | 9576 |
Uniprot: | O75602 |
セルラーロケーション: | Cell projection, Cytoplasm, cilium, cytoskeleton, flagellum |
計算された分子量: | 30kDa/49kDa/52kDa/55kDa/63kDa |
観察された分子量: | 55kDa |
同義語: | SPAG6, CT141, Repro-SA-1, pf16 |
バックグラウンド: | The correlation of anti-sperm antibodies with cases of unexplained infertility implicates a role for these antibodies in blocking fertilization. Improved diagnosis and treatment of immunologic infertility, as well as identification of proteins for targeted contraception, are dependent on the identification and characterization of relevant sperm antigens. The protein expressed by this gene is recognized by anti-sperm antibodies from an infertile man. This protein localizes to the tail of permeabilized human sperm and contains eight contiguous armadillo repeats, a motif known to mediate protein-protein interactions. Studies in mice suggest that this protein is involved in sperm flagellar motility and maintenance of the structural integrity of mature sperm. Several transcript variants encoding different isoforms have been found for this gene. |
UniProt Protein Function: | SPAG6: Important for structural integrity of the central apparatus in the sperm tail and for flagellar motility. 4 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:Cell development/differentiation; Cancer Testis Antigen (CTA) Chromosomal Location of Human Ortholog: 10p12.2 Cellular Component: axoneme; microtubule cytoskeleton; nucleus Biological Process: spermatid development |
NCBI Summary: | The correlation of anti-sperm antibodies with cases of unexplained infertility implicates a role for these antibodies in blocking fertilization. Improved diagnosis and treatment of immunologic infertility, as well as identification of proteins for targeted contraception, are dependent on the identification and characterization of relevant sperm antigens. The protein expressed by this gene is recognized by anti-sperm antibodies from an infertile man. This protein localizes to the tail of permeabilized human sperm and contains eight contiguous armadillo repeats, a motif known to mediate protein-protein interactions. Studies in mice suggest that this protein is involved in sperm flagellar motility and maintenance of the structural integrity of mature sperm. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011] |
UniProt Code: | O75602 |
NCBI GenInfo Identifier: | 62901067 |
NCBI Gene ID: | 9576 |
NCBI Accession: | O75602.1 |
UniProt Secondary Accession: | O75602,Q5VUX5, Q5VUX6, Q5VUX7, Q6FI74, Q8NHQ6, A8K1I8 B4DXZ4, |
UniProt Related Accession: | O75602 |
Molecular Weight: | 52,466 Da |
NCBI Full Name: | Sperm-associated antigen 6 |
NCBI Synonym Full Names: | sperm associated antigen 6 |
NCBI Official Symbol: | SPAG6 |
NCBI Official Synonym Symbols: | pf16; CT141; Repro-SA-1 |
NCBI Protein Information: | sperm-associated antigen 6 |
UniProt Protein Name: | Sperm-associated antigen 6 |
UniProt Synonym Protein Names: | Protein PF16 homolog; Repro-SA-1; Sperm flagellar protein |
Protein Family: | Sperm-associated antigen |
UniProt Gene Name: | SPAG6 |
UniProt Entry Name: | SPAG6_HUMAN |
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