Anti-SP3 Antibody (CAB12790)
- SKU:
- CAB12790
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Epigenetics and Nuclear Signaling
Frequently bought together:
Description
抗体名: | Anti-SP3 Antibody |
抗体コード: | CAB12790 |
抗体サイズ: | 20uL, 50uL, 100uL |
申し込み: | WB IHC |
反応性: | Human, Mouse, Rat |
宿主種: | Rabbit |
免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 240-350 of human SP3 (NP_003102.1). |
申し込み: | WB IHC |
推奨希釈: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 |
反応性: | Human, Mouse, Rat |
ポジティブサンプル: | A-549, PC-3, Mouse liver, Mouse brain, Rat testis |
免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 240-350 of human SP3 (NP_003102.1). |
精製方法: | Affinity purification |
ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
アイソタイプ: | IgG |
順序: | AIGG SSFP GQTQ VVAN VPLG LPGN ITFV PINS VDLD SLGL SGSS QTMT AGIN ADGH LINT GQAM DSSD NSER TGER VSPD INET NTDT DLFV PTSS SSQL PVTI DSTG ILQ |
遺伝子ID: | 6670 |
Uniprot: | Q02447 |
セルラーロケーション: | Nucleus, PML body |
計算された分子量: | 52kDa/53kDa/75kDa/76kDa/80kDa/81kDa |
観察された分子量: | 70kDa |
同義語: | SP3, SPR2 |
バックグラウンド: | This gene belongs to a family of Sp1 related genes that encode transcription factors that regulate transcription by binding to consensus GC- and GT-box regulatory elements in target genes. This protein contains a zinc finger DNA-binding domain and several transactivation domains, and has been reported to function as a bifunctional transcription factor that either stimulates or represses the transcription of numerous genes. Transcript variants encoding different isoforms have been described for this gene, and one has been reported to initiate translation from a non-AUG (AUA) start codon. Additional isoforms, resulting from the use of alternate downstream translation initiation sites, have also been noted. A related pseudogene has been identified on chromosome 13. |
UniProt Protein Function: | Transcriptional factor that can act as an activator or repressor depending on isoform and/or post-translational modifications. Binds to GT and GC boxes promoter elements. Competes with SP1 for the GC-box promoters. Weak activator of transcription but can activate a number of genes involved in different processes such as cell-cycle regulation, hormone-induction and house-keeping. |
NCBI Summary: | This gene belongs to a family of Sp1 related genes that encode transcription factors that regulate transcription by binding to consensus GC- and GT-box regulatory elements in target genes. This protein contains a zinc finger DNA-binding domain and several transactivation domains, and has been reported to function as a bifunctional transcription factor that either stimulates or represses the transcription of numerous genes. Transcript variants encoding different isoforms have been described for this gene, and one has been reported to initiate translation from a non-AUG (AUA) start codon. Additional isoforms, resulting from the use of alternate downstream translation initiation sites, have also been noted. A related pseudogene has been identified on chromosome 13. [provided by RefSeq, Feb 2010] |
UniProt Code: | Q02447 |
NCBI GenInfo Identifier: | 30923147 |
NCBI Gene ID: | 6670 |
NCBI Accession: | Q02447.3 |
UniProt Secondary Accession: | Q02447,Q69B26, Q69B27, Q8TD56, Q8WWU4, Q9BQR1, A0AVL9 B4E2B7, |
UniProt Related Accession: | Q02447 |
Molecular Weight: | 76,814 Da |
NCBI Full Name: | Transcription factor Sp3 |
NCBI Synonym Full Names: | Sp3 transcription factor |
NCBI Official Symbol: | SP3 |
NCBI Official Synonym Symbols: | SPR2 |
NCBI Protein Information: | transcription factor Sp3 |
UniProt Protein Name: | Transcription factor Sp3 |
UniProt Synonym Protein Names: | SPR-2 |
Protein Family: | Transcription factor |
UniProt Gene Name: | SP3 |
UniProt Entry Name: | SP3_HUMAN |
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