Anti-SOX7 Antibody (CAB14941)
- SKU:
- CAB14941
- Product type:
- Antibody
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Epigenetics and Nuclear Signaling
Frequently bought together:
Description
抗体名: | Anti-SOX7 Antibody |
抗体コード: | CAB14941 |
抗体サイズ: | 20uL, 50uL, 100uL |
申し込み: | WB |
反応性: | Mouse |
宿主種: | Rabbit |
免疫原: | A synthetic peptide corresponding to a sequence within amino acids 250-350 of human SOX7 (NP_113627.1). |
申し込み: | WB |
推奨希釈: | WB 1:500 - 1:2000 |
反応性: | Mouse |
ポジティブサンプル: | Mouse heart |
免疫原: | A synthetic peptide corresponding to a sequence within amino acids 250-350 of human SOX7 (NP_113627.1). |
精製方法: | Affinity purification |
ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
アイソタイプ: | IgG |
順序: | PLHC SHPL GSLA LGQS PGVS MMSP VPGC PPSP AYYS PATY HPLH SNLQ AHLG QLSP PPEH PGFD ALDQ LSQV ELLG DMDR NEFD QYLN TPGH PDSA TGAM A |
遺伝子ID: | 83595 |
Uniprot: | Q9BT81 |
セルラーロケーション: | Cytoplasm, Nucleus |
計算された分子量: | 42kDa/48kDa |
観察された分子量: | 42kDa |
同義語: | SOX7, SRY-box 7 |
バックグラウンド: | This gene encodes a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of the cell fate. The encoded protein may act as a transcriptional regulator after forming a protein complex with other proteins. The protein may play a role in tumorigenesis. A similar protein in mice is involved in the regulation of the wingless-type MMTV integration site family (Wnt) pathway. |
UniProt Protein Function: | SOX7: Binds to and activates the CDH5 promoter, hence plays a role in the transcriptional regulation of genes expressed in the hemogenic endothelium and blocks further differentiation into blood precursors. May be required for the survival of both hematopoietic and endothelial precursors during specification. Competes with GATA4 for binding and activation of the FGF3 promoter. Represses Wnt/beta-catenin-stimulated transcription, probably by targeting CTNNB1 to proteasomal degradation. Binds the DNA sequence 5'- AACAAT-3'. |
UniProt Protein Details: | Protein type:Transcription factor; DNA-binding Chromosomal Location of Human Ortholog: 8p23.1 Cellular Component: cytoplasm; nucleus Molecular Function:RNA polymerase II transcription factor activity, enhancer binding; sequence-specific DNA binding; transcription factor activity Biological Process: regulation of transcription from RNA polymerase II promoter; transcription from RNA polymerase II promoter; negative regulation of cell proliferation; endoderm formation; positive regulation of transcription, DNA-dependent; positive regulation of caspase activity; negative regulation of transcription, DNA-dependent |
NCBI Summary: | This gene encodes a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of the cell fate. The encoded protein may act as a transcriptional regulator after forming a protein complex with other proteins. The protein may play a role in tumorigenesis. A similar protein in mice is involved in the regulation of the wingless-type MMTV integration site family (Wnt) pathway. [provided by RefSeq, Jul 2008] |
UniProt Code: | Q9BT81 |
NCBI GenInfo Identifier: | 20532272 |
NCBI Gene ID: | 83595 |
NCBI Accession: | Q9BT81.1 |
UniProt Related Accession: | Q9BT81 |
Molecular Weight: | |
NCBI Full Name: | Transcription factor SOX-7 |
NCBI Synonym Full Names: | SRY-box transcription factor 7 |
NCBI Official Symbol: | SOX7 |
NCBI Protein Information: | transcription factor SOX-7 |
UniProt Protein Name: | Transcription factor SOX-7 |
Protein Family: | Transcription factor |
UniProt Gene Name: | SOX7 |
UniProt Entry Name: | SOX7_HUMAN |
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