Anti-SNX9 Antibody (CAB0977)
- SKU:
- CAB0977
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Cycle
Frequently bought together:
Description
| 抗体名: | Anti-SNX9 Antibody |
| 抗体コード: | CAB0977 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB |
| 反応性: | Human, Mouse, Rat |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-210 of human SNX9 (NP_057308.1). |
| 申し込み: | WB |
| 推奨希釈: | WB 1:500 - 1:2000 |
| 反応性: | Human, Mouse, Rat |
| ポジティブサンプル: | A375, HeLa, Mouse liver, Rat liver, Rat heart |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-210 of human SNX9 (NP_057308.1). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | MATK ARVM YDFA AEPG NNEL TVNE GEII TITN PDVG GGWL EGRN IKGE RGLV PTDY VEIL PSDG KDQF SCGN SVAD QAFL DSLS ASTA QASS SAAS NNHQ VGSG NDPW SAWS ASKS GNWE SSEG WGAQ PEGA GAQR NTNT PNNW DTAF GHPQ AYQG PATG DDDD WDED WDGP KSSS YFKD SESA DAGG AQRG NSRA SSSS MKIP LNKF PG |
| 遺伝子ID: | 51429 |
| Uniprot: | Q9Y5X1 |
| セルラーロケーション: | Cell membrane, Cell projection, Cytoplasm, Cytoplasmic side, Cytoplasmic vesicle, Cytoplasmic vesicle membrane, Golgi apparatus, Peripheral membrane protein, clathrin-coated vesicle, ruffle, trans-Golgi network |
| 計算された分子量: | 66kDa |
| 観察された分子量: | 90kDa |
| 同義語: | SNX9, SDP1, SH3PX1, SH3PXD3A, WISP |
| バックグラウンド: | This gene encodes a member of the sorting nexin family. Members of this family contain a phosphoinositide binding domain, and are involved in intracellular trafficking. The encoded protein does not contain a coiled coil region, like some family members, but does contain a SRC homology domain near its N-terminus. The encoded protein is reported to have a variety of interaction partners, including of adaptor protein 2 , dynamin, tyrosine kinase non-receptor 2, Wiskott-Aldrich syndrome-like, and ARP3 actin-related protein 3. The encoded protein is implicated in several stages of intracellular trafficking, including endocytosis, macropinocytosis, and F-actin nucleation. |
| UniProt Protein Function: | SNX9: May be involved in several stages of intracellular trafficking. Plays a role in endocytosis via clathrin-coated pits, but also clathrin-independent, actin-dependent fluid-phase endocytosis. Plays a role in macropinocytosis. Promotes internalization of TNFR. Promotes degradation of EGFR after EGF signaling. Stimulates the GTPase activity of DNM1. Promotes DNM1 oligomerization. Promotes activation of the Arp2/3 complex by WASL, and thereby plays a role in the reorganization of the F- actin cytoskeleton. Binds to membranes enriched in phosphatidylinositol 4,5-bisphosphate and promotes membrane tubulation. Has lower affinity for membranes enriched in phosphatidylinositol 3-phosphate. Belongs to the sorting nexin family. |
| UniProt Protein Details: | Protein type:Vesicle Chromosomal Location of Human Ortholog: 6q25.3 Cellular Component: ruffle; extrinsic to internal side of plasma membrane; cytoplasmic vesicle membrane; clathrin-coated vesicle; cytoplasmic membrane-bound vesicle; cytoplasm; plasma membrane; trans-Golgi network; endosome Molecular Function:protein binding; protein homodimerization activity; ubiquitin protein ligase binding; phosphoinositide binding; phosphatidylinositol binding Biological Process: mitosis; intracellular protein transport; receptor-mediated endocytosis; positive regulation of protein oligomerization; cytokinesis after mitosis; positive regulation of protein kinase activity; vesicle organization and biogenesis; endocytosis; endosome transport; positive regulation of membrane protein ectodomain proteolysis; positive regulation of GTPase activity |
| NCBI Summary: | This gene encodes a member of the sorting nexin family. Members of this family contain a phosphoinositide binding domain, and are involved in intracellular trafficking. The encoded protein does not contain a coiled coil region, like some family members, but does contain a SRC homology domain near its N-terminus. The encoded protein is reported to have a variety of interaction partners, including of adaptor protein 2 , dynamin, tyrosine kinase non-receptor 2, Wiskott-Aldrich syndrome-like, and ARP3 actin-related protein 3. The encoded protein is implicated in several stages of intracellular trafficking, including endocytosis, macropinocytosis, and F-actin nucleation. [provided by RefSeq, Jul 2013] |
| UniProt Code: | Q9Y5X1 |
| NCBI GenInfo Identifier: | 12643956 |
| NCBI Gene ID: | 51429 |
| NCBI Accession: | Q9Y5X1.1 |
| UniProt Secondary Accession: | Q9Y5X1,Q9BSI7, Q9BVM1, Q9UJH6, Q9UP20, |
| UniProt Related Accession: | Q9Y5X1 |
| Molecular Weight: | 595 |
| NCBI Full Name: | Sorting nexin-9 |
| NCBI Synonym Full Names: | sorting nexin 9 |
| NCBI Official Symbol: | SNX9 |
| NCBI Official Synonym Symbols: | SDP1; WISP; SH3PX1; SH3PXD3A |
| NCBI Protein Information: | sorting nexin-9; SH3 and PX domain-containing protein 1; SH3 and PX domain-containing protein 3A; Wiskott-Aldrich syndrome protein (WASP) interactor protein |
| UniProt Protein Name: | Sorting nexin-9 |
| UniProt Synonym Protein Names: | SH3 and PX domain-containing protein 1; Protein SDP1; SH3 and PX domain-containing protein 3A |
| Protein Family: | Sorting nexin |
| UniProt Gene Name: | SNX9 |
| UniProt Entry Name: | SNX9_HUMAN |
 | Western blot analysis of extracts of various cell lines, using SNX9 antibody (CAB0977) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 1s. |
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