Anti-SNX6 Antibody (CAB10039)
- SKU:
- CAB10039
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Frequently bought together:
Description
| 抗体名: | Anti-SNX6 Antibody |
| 抗体コード: | CAB10039 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB |
| 反応性: | Human, Mouse, Rat |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-290 of human SNX6 (NP_067072.3). |
| 申し込み: | WB |
| 推奨希釈: | WB 1:500 - 1:2000 |
| 反応性: | Human, Mouse, Rat |
| ポジティブサンプル: | HepG2, DU145, BT-474, Mouse kidney, Mouse lung, Mouse thymus, Mouse pancreas, Rat kidney |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-290 of human SNX6 (NP_067072.3). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | MTKE EFTK MKQE LEAE YLAI FKKT VAMH EVFL CRVA AHPI LRRD LNFH VFLE YNQD LSVR GKNK KEKL EDFF KNMV KSAD GVIV SGVK DVDD FFEH ERTF LLEY HNRV KDAS AKSD RMTR SHKS AADD YNRI GSSL YALG TQDS TDIC KFFL KVSE LFDK TRKI EARV SADE DLKL SDLL KYYL RESQ AAKD LLYR RSRS LVDY ENAN KALD KARA KNKD VLQA ETSQ QLCC QKFE KISE SAKQ ELID FKTR RVAA FRKN LVEL AELE LKHA KGNL QLLQ NCLA VLNG DT |
| 遺伝子ID: | 58533 |
| Uniprot: | Q9UNH7 |
| セルラーロケーション: | Cytoplasm, Cytoplasmic side, Cytoplasmic vesicle, Early endosome, Early endosome membrane, Nucleus, Peripheral membrane protein |
| 計算された分子量: | 33kDa/46kDa |
| 観察された分子量: | 46kDa |
| 同義語: | SNX6, MSTP010, TFAF2 |
| バックグラウンド: | This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. This protein associates with the long isoform of the leptin receptor, the transforming growth factor-beta family of receptor serine-threonine kinases, and with receptor tyrosine kinases for platelet-derived growth factor, insulin, and epidermal growth factor. This protein may form oligomeric complexes with family member proteins through interactions of both the PX domain and the coiled coil regions of the molecules. Translocation of this protein from the cytoplasm to the nucleus occurs after binding to proviral integration site 1 protein. This gene results in two transcripts encoding two distinct isoforms. |
| UniProt Protein Function: | SNX6: May be involved in several stages of intracellular trafficking. Promotes lysosomal degradation of CDKN1B. Plays a role in retrograde protein transport from endosomes to the trans-Golgi network. May function as link between transport vesicles and dynactin. Negatively regulates retrograde transport of BACE1 from the cell surface to the trans-Golgi network. May contribute to transcription regulation. Belongs to the sorting nexin family. |
| UniProt Protein Details: | Protein type:Vesicle Chromosomal Location of Human Ortholog: 14q13.1 Cellular Component: cytoplasm; early endosome membrane; extrinsic to membrane; retromer complex Molecular Function:phosphoinositide binding; protein binding; protein homodimerization activity Biological Process: endocytosis; intracellular protein transport; negative regulation of transcription, DNA-dependent; negative regulation of transforming growth factor beta receptor signaling pathway; retrograde transport, endosome to Golgi; vesicle organization and biogenesis |
| NCBI Summary: | This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. This protein associates with the long isoform of the leptin receptor, the transforming growth factor-beta family of receptor serine-threonine kinases, and with receptor tyrosine kinases for platelet-derived growth factor, insulin, and epidermal growth factor. This protein may form oligomeric complexes with family member proteins through interactions of both the PX domain and the coiled coil regions of the molecules. Translocation of this protein from the cytoplasm to the nucleus occurs after binding to proviral integration site 1 protein. This gene results in two transcripts encoding two distinct isoforms. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q9UNH7 |
| NCBI GenInfo Identifier: | 10720285 |
| NCBI Gene ID: | 58533 |
| NCBI Accession: | Q9UNH7.1 |
| UniProt Secondary Accession: | Q9UNH7,Q9Y449, C0H5W9, |
| UniProt Related Accession: | Q9UNH7 |
| Molecular Weight: | 33,570 Da |
| NCBI Full Name: | Sorting nexin-6 |
| NCBI Synonym Full Names: | sorting nexin 6 |
| NCBI Official Symbol: | SNX6 |
| NCBI Official Synonym Symbols: | TFAF2; MSTP010 |
| NCBI Protein Information: | sorting nexin-6 |
| UniProt Protein Name: | Sorting nexin-6 |
| UniProt Synonym Protein Names: | TRAF4-associated factor 2 |
| Protein Family: | Sorting nexin |
| UniProt Gene Name: | SNX6 |
| UniProt Entry Name: | SNX6_HUMAN |
 | Western blot analysis of extracts of various cell lines, using SNX6 antibody (CAB10039) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 5s. |
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