Anti-SNX15 Antibody (CAB9158)
- SKU:
- CAB9158
- Product type:
- Antibody
- Application:
- WB
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
Frequently bought together:
Description
抗体名: | Anti-SNX15 Antibody |
抗体コード: | CAB9158 |
抗体サイズ: | 20uL, 50uL, 100uL |
申し込み: | WB IF |
反応性: | Human, Mouse, Rat |
宿主種: | Rabbit |
免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-342 of human SNX15 (NP_037438.2). |
申し込み: | WB IF |
推奨希釈: | WB 1:500 - 1:2000 IF 1:50 - 1:200 |
反応性: | Human, Mouse, Rat |
ポジティブサンプル: | U-87MG, HepG2, Jurkat, Raji, Mouse spleen |
免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-342 of human SNX15 (NP_037438.2). |
精製方法: | Affinity purification |
ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
アイソタイプ: | IgG |
順序: | MSRQ AKDD FLRH YTVS DPRT HPKG YTEY KVTA QFIS KKDP EDVK EVVV WKRY SDFR KLHG DLAY THRN LFRR LEEF PAFP RAQV FGRF EASV IEER RKGA EDLL RFTV HIPA LNNS PQLK EFFR GGEV TRPL EVSR DLHI LPPP LIPT PPPD DPRL SQLL PAER RGLE ELEV PVDP PPSS PAQE ALDL LFNC ESTE EASG SPAR GPLT EAEL ALFD PFSK EEGA APSP THVA ELAT MEVE SARL DQEP WEPG GQEE EEDG EGGP TPAY LSQA TELI TQAL RDEK AGAY AAAL QGYR DGVH VLLQ GVPS DPLP ARQE GVKK KAAE YLKR AEEI LRLH LSQL PP |
遺伝子ID: | 29907 |
Uniprot: | Q9NRS6 |
セルラーロケーション: | Cytoplasm, Cytoplasmic side, Cytoplasmic vesicle membrane, Membrane, Peripheral membrane protein |
計算された分子量: | 29kDa/38kDa |
観察された分子量: | 50kDa |
同義語: | SNX15, HSAF001435 |
バックグラウンド: | This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. Overexpression of this gene results in a decrease in the processing of insulin and hepatocyte growth factor receptors to their mature subunits. This decrease is caused by the mislocalization of furin, the endoprotease responsible for cleavage of insulin and hepatocyte growth factor receptors. This protein is involved in endosomal trafficking from the plasma membrane to recycling endosomes or the trans-Golgi network. Alternative splicing results in multiple transcript variants. Read-through transcription also exists between this gene and the upstream ADP-ribosylation factor-like 2 (ARL2) gene. |
UniProt Protein Function: | SNX15: May be involved in several stages of intracellular trafficking. Overexpression of SNX15 disrupts the normal trafficking of proteins from the plasma membrane to recycling endosomes or the TGN. Belongs to the sorting nexin family. 2 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Chromosomal Location of Human Ortholog: 11q12 Cellular Component: cytoplasm; intracellular membrane-bound organelle; nucleolus Molecular Function:protein binding; protein serine/threonine kinase activity Biological Process: signal transduction |
NCBI Summary: | This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. Overexpression of this gene results in a decrease in the processing of insulin and hepatocyte growth factor receptors to their mature subunits. This decrease is caused by the mislocalization of furin, the endoprotease responsible for cleavage of insulin and hepatocyte growth factor receptors. This protein is involved in endosomal trafficking from the plasma membrane to recycling endosomes or the trans-Golgi network. Alternative splicing results in multiple transcript variants. Read-through transcription also exists between this gene and the upstream ADP-ribosylation factor-like 2 (ARL2) gene. [provided by RefSeq, Dec 2010] |
UniProt Code: | Q9NRS6 |
NCBI GenInfo Identifier: | 13124562 |
NCBI Gene ID: | 29907 |
NCBI Accession: | Q9NRS6.1 |
UniProt Secondary Accession: | Q9NRS6,Q9NRS5, E5KQS6, |
UniProt Related Accession: | Q9NRS6 |
Molecular Weight: | 29,220 Da |
NCBI Full Name: | Sorting nexin-15 |
NCBI Synonym Full Names: | sorting nexin 15 |
NCBI Official Symbol: | SNX15 |
NCBI Official Synonym Symbols: | HSAF001435 |
NCBI Protein Information: | sorting nexin-15 |
UniProt Protein Name: | Sorting nexin-15 |
Protein Family: | Sorting nexin |
UniProt Gene Name: | SNX15 |
UniProt Entry Name: | SNX15_HUMAN |
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