Anti-SNX13 Antibody (CAB12821)
- SKU:
- CAB12821
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Frequently bought together:
Description
| 抗体名: | Anti-SNX13 Antibody |
| 抗体コード: | CAB12821 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB IF |
| 反応性: | Human, Mouse |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 50-230 of human SNX13 (NP_055947.1). |
| 申し込み: | WB IF |
| 推奨希釈: | WB 1:500 - 1:2000 IF 1:50 - 1:200 |
| 反応性: | Human, Mouse |
| ポジティブサンプル: | U-87MG, HeLa |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 50-230 of human SNX13 (NP_055947.1). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | FGKT NSEK YLEQ CEHS FLPP TSPG VPKC LEEM KREA RTIK IDRR LTGA NIID EPLQ QVIQ FSLR DYVQ YWYY TLSD DESF LLEI RQTL QNAL IQFA TRSK EIDW QPYF TTRI VDDF GTHL RVFR KAQQ KITE KDDQ VKGT AEDL VDTF FEVE VEME KEVC RDLV CTSP KDEE GFLR DLCE V |
| 遺伝子ID: | 23161 |
| Uniprot: | Q9Y5W8 |
| セルラーロケーション: | Cytoplasmic side, Early endosome membrane, Peripheral membrane protein |
| 計算された分子量: | 110kDa/112kDa |
| 観察された分子量: | 112kDa |
| 同義語: | SNX13, RGS-PX1 |
| バックグラウンド: | This gene encodes a PHOX domain- and RGS domain-containing protein that belongs to the sorting nexin (SNX) family and the regulator of G protein signaling (RGS) family. The PHOX domain is a phosphoinositide binding domain, and the SNX family members are involved in intracellular trafficking. The RGS family members are regulatory molecules that act as GTPase activating proteins for G alpha subunits of heterotrimeric G proteins. The RGS domain of this protein interacts with G alpha(s), accelerates its GTP hydrolysis, and attenuates G alpha(s)-mediated signaling. Overexpression of this protein delayes lysosomal degradation of the epidermal growth factor receptor. Because of its bifunctional role, this protein may link heterotrimeric G protein signaling and vesicular trafficking. |
| UniProt Protein Function: | SNX13: May be involved in several stages of intracellular trafficking. May play a role in endosome homeostasis. Acts as a GAP for Galphas. Belongs to the sorting nexin family. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Chromosomal Location of Human Ortholog: 7p21.1 Cellular Component: early endosome Molecular Function:phosphatidylinositol 3-phosphate binding; phosphoinositide binding Biological Process: intracellular protein transport; positive regulation of GTPase activity |
| NCBI Summary: | This gene encodes a PHOX domain- and RGS domain-containing protein that belongs to the sorting nexin (SNX) family and the regulator of G protein signaling (RGS) family. The PHOX domain is a phosphoinositide binding domain, and the SNX family members are involved in intracellular trafficking. The RGS family members are regulatory molecules that act as GTPase activating proteins for G alpha subunits of heterotrimeric G proteins. The RGS domain of this protein interacts with G alpha(s), accelerates its GTP hydrolysis, and attenuates G alpha(s)-mediated signaling. Overexpression of this protein delayes lysosomal degradation of the epidermal growth factor receptor. Because of its bifunctional role, this protein may link heterotrimeric G protein signaling and vesicular trafficking. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q9Y5W8 |
| NCBI GenInfo Identifier: | 24418867 |
| NCBI Gene ID: | 23161 |
| NCBI Accession: | Q9Y5W8.4 |
| UniProt Secondary Accession: | Q9Y5W8,O94821, Q8WVZ2, Q8WXH8, B2RCI9, |
| UniProt Related Accession: | Q9Y5W8 |
| Molecular Weight: | 112kDa |
| NCBI Full Name: | Sorting nexin-13 |
| NCBI Synonym Full Names: | sorting nexin 13 |
| NCBI Official Symbol: | SNX13 |
| NCBI Official Synonym Symbols: | RGS-PX1 |
| NCBI Protein Information: | sorting nexin-13 |
| UniProt Protein Name: | Sorting nexin-13 |
| UniProt Synonym Protein Names: | RGS domain- and PHOX domain-containing protein; RGS-PX1 |
| Protein Family: | Sorting nexin |
| UniProt Gene Name: | SNX13 |
 | Western blot analysis of extracts of various cell lines, using SNX13 antibody (CAB12821) at 1:3000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s. |
 | Immunofluorescence analysis of mouse brain using SNX13 antibody (CAB12821) at dilution of 1:100. Blue: DAPI for nuclear staining. |
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