| 同義語: | SNW1, Bx42, NCOA-62, PRPF45, Prp45, SKIIP, SKIP, FUN20, SKIP1 |
| バックグラウンド: | This gene, a member of the SNW gene family, encodes a coactivator that enhances transcription from some Pol II promoters. This coactivator can bind to the ligand-binding domain of the vitamin D receptor and to retinoid receptors to enhance vitamin D-, retinoic acid-, estrogen-, and glucocorticoid-mediated gene expression. It can also function as a splicing factor by interacting with poly(A)-binding protein 2 to directly control the expression of muscle-specific genes at the transcriptional level. Finally, the protein may be involved in oncogenesis since it interacts with a region of SKI oncoproteins that is required for transforming activity. Alternative splicing results in multiple transcript variants. |
| UniProt Protein Function: | Skip: Involved in vitamin D-mediated transcription. Can function as a splicing factor in pre-mRNA splicing. Belongs to the SNW family. |
| UniProt Protein Details: | Protein type:Nuclear receptor co-regulator; Transcription, coactivator/corepressor; Spliceosome Chromosomal Location of Human Ortholog: 14q24.3 Cellular Component: nuclear matrix; nucleoplasm; nucleus; spliceosome; transcription elongation factor complex b Molecular Function:Notch binding; nuclear hormone receptor binding; protein binding; retinoic acid receptor binding; SMAD binding; transcription coactivator activity; transcription corepressor activity; vitamin D receptor binding Biological Process: DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis; negative regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent; Notch signaling pathway; nuclear mRNA splicing, via spliceosome; positive regulation of histone H3-K4 methylation; positive regulation of neurogenesis; positive regulation of nuclear mRNA splicing, via spliceosome; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transforming growth factor beta receptor signaling pathway; regulation of retinoic acid receptor signaling pathway; regulation of transcription from RNA polymerase II promoter; retinoic acid receptor signaling pathway; transcription initiation from RNA polymerase II promoter |
| NCBI Summary: | This gene, a member of the SNW gene family, encodes a coactivator that enhances transcription from some Pol II promoters. This coactivator can bind to the ligand-binding domain of the vitamin D receptor and to retinoid receptors to enhance vitamin D-, retinoic acid-, estrogen-, and glucocorticoid-mediated gene expression. It can also function as a splicing factor by interacting with poly(A)-binding protein 2 to directly control the expression of muscle-specific genes at the transcriptional level. Finally, the protein may be involved in oncogenesis since it interacts with a region of SKI oncoproteins that is required for transforming activity. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016] |
| UniProt Code: | Q13573 |
| NCBI GenInfo Identifier: | 2500813 |
| NCBI Gene ID: | 22938 |
| NCBI Accession: | Q13573.1 |
| UniProt Secondary Accession: | Q13573,Q13483, Q32N03, Q5D0D6, A8K8A9, |
| UniProt Related Accession: | Q13573 |
| Molecular Weight: | 61,494 Da |
| NCBI Full Name: | SNW domain-containing protein 1 |
| NCBI Synonym Full Names: | SNW domain containing 1 |
| NCBI Official Symbol: | SNW1 |
| NCBI Official Synonym Symbols: | Bx42; SKIP; Prp45; SKIIP; PRPF45; NCOA-62 |
| NCBI Protein Information: | SNW domain-containing protein 1 |
| UniProt Protein Name: | SNW domain-containing protein 1 |
| UniProt Synonym Protein Names: | Nuclear protein SkiP; Nuclear receptor coactivator NCoA-62; Ski-interacting protein |
| Protein Family: | SNW domain-containing protein |
| UniProt Gene Name: | SNW1 |
| UniProt Entry Name: | SNW1_HUMAN |
