Anti-SNTB2 Antibody (CAB18384)
- SKU:
- CAB18384
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
Frequently bought together:
Description
| 抗体名: | Anti-SNTB2 Antibody |
| 抗体コード: | CAB18384 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB |
| 反応性: | Human, Mouse |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant protein of human SNTB2. |
| 申し込み: | WB |
| 推奨希釈: | WB 1:500 - 1:2000 |
| 反応性: | Human, Mouse |
| ポジティブサンプル: |
| 免疫原: | Recombinant protein of human SNTB2. |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | Email for sequence |
| 遺伝子ID: | 6645 |
| Uniprot: | Q13425 |
| セルラーロケーション: | |
| 計算された分子量: | |
| 観察された分子量: | Refer to figures |
| 同義語: | D16S2531E, EST25263, SNT2B2, SNT3, SNTL, SNTB2 |
| バックグラウンド: |
| UniProt Protein Function: | SNTB2: Adapter protein that binds to and probably organizes the subcellular localization of a variety of membrane proteins. May link various receptors to the actin cytoskeleton and the dystrophin glycoprotein complex. May play a role in the regulation of secretory granules via its interaction with PTPRN. Monomer and homodimer (Probable). Interacts with the other members of the syntrophin family: SNTA1 and SNTB1; and with the sodium channel proteins SCN4A and SCN5A. Interacts with SAST, MAST205, microtubules and microtubule-associated proteins. Interacts with the dystrophin protein DMD and related proteins DTNA and UTRN, and with the neuroregulin receptor ERBB4. Interacts with PTPRN when phosphorylated, protecting PTPRN from protein cleavage by CAPN1. Dephosphorylation upon insulin stimulation disrupts the interaction with PTPRN and results in the cleavage of PTPRN. Ubiquitous. Isoform 1 is the predominant isoform. Weak level of isoform 2 is present in all tested tissues, except in liver and heart where it is highly expressed. Belongs to the syntrophin family. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Extracellular matrix; Dystrophin complex; Adaptor/scaffold Chromosomal Location of Human Ortholog: 16q22.1 Cellular Component: cytoplasm; dystrophin-associated glycoprotein complex; focal adhesion; membrane; protein complex Molecular Function:protein binding |
| NCBI Summary: | Dystrophin is a large, rod-like cytoskeletal protein found at the inner surface of muscle fibers. Dystrophin is missing in Duchenne Muscular Dystrophy patients and is present in reduced amounts in Becker Muscular Dystrophy patients. The protein encoded by this gene is a peripheral membrane protein found associated with dystrophin and dystrophin-related proteins. This gene is a member of the syntrophin gene family, which contains at least two other structurally-related genes. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q13425 |
| NCBI GenInfo Identifier: | 23822158 |
| NCBI Gene ID: | 6645 |
| NCBI Accession: | Q13425.1 |
| UniProt Secondary Accession: | Q13425,Q9BY09, |
| UniProt Related Accession: | Q13425 |
| Molecular Weight: | 27,677 Da |
| NCBI Full Name: | Beta-2-syntrophin |
| NCBI Synonym Full Names: | syntrophin beta 2 |
| NCBI Official Symbol: | SNTB2 |
| NCBI Official Synonym Symbols: | SNT3; SNTL; SNT2B2; EST25263; D16S2531E |
| NCBI Protein Information: | beta-2-syntrophin |
| UniProt Protein Name: | Beta-2-syntrophin |
| UniProt Synonym Protein Names: | 59 kDa dystrophin-associated protein A1 basic component 2; Syntrophin-3; SNT3; Syntrophin-like; SNTL |
| Protein Family: | Beta-2-syntrophin |
| UniProt Gene Name: | SNTB2 |
| UniProt Entry Name: | SNTB2_HUMAN |