Anti-SNIP1 Antibody (CAB16747)
- SKU:
- CAB16747
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Epigenetics and Nuclear Signaling
Frequently bought together:
Description
抗体名: | Anti-SNIP1 Antibody |
抗体コード: | CAB16747 |
抗体サイズ: | 20uL, 50uL, 100uL |
申し込み: | WB IHC IF |
反応性: | Human, Rat |
宿主種: | Rabbit |
免疫原: | Recombinant protein of human SNIP1. |
申し込み: | WB IHC IF |
推奨希釈: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 IF 1:50 - 1:200 |
反応性: | Human, Rat |
ポジティブサンプル: | BxPC-3 |
免疫原: | Recombinant protein of human SNIP1. |
精製方法: | Affinity purification |
ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
アイソタイプ: | IgG |
順序: | Email for sequence |
遺伝子ID: | 79753 |
Uniprot: | Q8TAD8 |
セルラーロケーション: | |
計算された分子量: | 45kDa |
観察された分子量: | 46kDa |
同義語: | SNIP1, PML1, PMRED |
バックグラウンド: | This gene encodes a protein that contains a coiled-coil motif and C-terminal forkhead-associated (FHA) domain. The encoded protein functions as a transcriptional coactivator that increases c-Myc activity and inhibits transforming growth factor beta (TGF-beta) and nuclear factor kappa-B (NF-kB) signaling. The encoded protein also regulates the stability of cyclin D1 mRNA, and may play a role in cell proliferation and cancer progression. Mutations in this gene are a cause of psychomotor retardation, epilepsy, and craniofacial dysmorphism (PMRED). |
UniProt Protein Function: | SNIP1: Down-regulates NF-kappa-B signaling by competing with RELA for CREBBP/EP300 binding. Involved in the microRNA (miRNA) biogenesis. Defects in SNIP1 are the cause of psychomotor retardation, epilepsy, and craniofacial dysmorphism (PMRED). A disease characterized by severe psychomotor retardation, intractable seizures, dysmorphic features, and a lumpy skull surface. Patients are hypotonic and have poor feeding in the neonatal period. |
UniProt Protein Details: | Protein type:Inhibitor Chromosomal Location of Human Ortholog: 1p34.3 Cellular Component: nucleoplasm; cytoplasm Molecular Function:protein binding Biological Process: miRNA-mediated gene silencing, production of miRNAs; I-kappaB kinase/NF-kappaB cascade; regulation of transcription, DNA-dependent Disease: Psychomotor Retardation, Epilepsy, And Craniofacial Dysmorphism |
NCBI Summary: | This gene encodes a protein that contains a coiled-coil motif and C-terminal forkhead-associated (FHA) domain. The encoded protein functions as a transcriptional coactivator that increases c-Myc activity and inhibits transforming growth factor beta (TGF-beta) and nuclear factor kappa-B (NF-kB) signaling. The encoded protein also regulates the stability of cyclin D1 mRNA, and may play a role in cell proliferation and cancer progression. Mutations in this gene are a cause of psychomotor retardation, epilepsy, and craniofacial dysmorphism (PMRED). [provided by RefSeq, Mar 2012] |
UniProt Code: | Q8TAD8 |
NCBI GenInfo Identifier: | 48428655 |
NCBI Gene ID: | 79753 |
NCBI Accession: | Q8TAD8.1 |
UniProt Related Accession: | Q8TAD8 |
Molecular Weight: | 46 kDa |
NCBI Full Name: | Smad nuclear-interacting protein 1 |
NCBI Synonym Full Names: | Smad nuclear interacting protein 1 |
NCBI Official Symbol: | SNIP1 |
NCBI Official Synonym Symbols: | PML1; PMRED |
NCBI Protein Information: | smad nuclear-interacting protein 1 |
UniProt Protein Name: | Smad nuclear-interacting protein 1 |
UniProt Synonym Protein Names: | FHA domain-containing protein SNIP1 |
Protein Family: | Smad nuclear interacting protein |
UniProt Gene Name: | SNIP1 |
UniProt Entry Name: | SNIP1_HUMAN |
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