Anti-SNAPIN Antibody (CAB10294)
- SKU:
- CAB10294
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Frequently bought together:
Description
| 抗体名: | Anti-SNAPIN Antibody |
| 抗体コード: | CAB10294 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB |
| 反応性: | Human, Mouse, Rat |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-136 of human SNAPIN (NP_036569.1). |
| 申し込み: | WB |
| 推奨希釈: | WB 1:200 - 1:2000 |
| 反応性: | Human, Mouse, Rat |
| ポジティブサンプル: | U-87MG, A375, HeLa, Jurkat, Mouse lung, Mouse heart, Rat kidney |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-136 of human SNAPIN (NP_036569.1). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | MAGA GSAA VSGA GTPV AGPT GRDL FAEG LLEF LRPA VQQL DSHV HAVR ESQV ELRE QIDN LATE LCRI NEDQ KVAL DLDP YVKK LLNA RRRV VLVN NILQ NAQE RLRR LNHS VAKE TARR RAML DSGI YPPG SPGK |
| 遺伝子ID: | 23557 |
| Uniprot: | O95295 |
| セルラーロケーション: | Cytoplasm, Cytoplasmic side, Cytoplasmic vesicle, Cytoplasmic vesicle membrane, Golgi apparatus membrane, Membrane, Peripheral membrane protein, perinuclear region, secretory vesicle, synaptic vesicle membrane |
| 計算された分子量: | 14kDa |
| 観察された分子量: | 15kDa |
| 同義語: | SNAPIN, BLOC1S7, BLOS7, BORCS3, SNAPAP |
| バックグラウンド: | The protein encoded by this gene is a coiled-coil-forming protein that associates with the SNARE (soluble N-ethylmaleimide-sensitive fusion protein attachment protein receptor) complex of proteins and the BLOC-1 (biogenesis of lysosome-related organelles) complex. Biochemical studies have identified additional binding partners. As part of the SNARE complex, it is required for vesicle docking and fusion and regulates neurotransmitter release. The BLOC-1 complex is required for the biogenesis of specialized organelles such as melanosomes and platelet dense granules. Mutations in gene products that form the BLOC-1 complex have been identified in mouse strains that are models of Hermansky-Pudlak syndrome. Alternative splicing results in multiple transcript variants. |
| UniProt Protein Function: | SNAPIN: a component of the SNARE complex of proteins that is required for synaptic vesicle docking and fusion. May modulate a step between vesicle priming, fusion and calcium-dependent neurotransmitter release by potentiating the interaction of synaptotagmins with the SNAREs and the plasma-membrane-associated protein SNAP25. Its phosphorylation state influences exocytotic protein interactions and may regulate synaptic vesicle exocytosis. May also have a role in the mechanisms of SNARE-mediated membrane fusion in non-neuronal cells. Phosphorylation by PKA modulates its interaction with the SNARE complex. |
| UniProt Protein Details: | Protein type:Vesicle Chromosomal Location of Human Ortholog: 1q21.3 Cellular Component: perinuclear region of cytoplasm; secretory granule; synapse; synaptic vesicle Molecular Function:protein binding; SNARE binding Biological Process: anterograde axon cargo transport; anterograde synaptic vesicle transport; endosome to lysosome transport; lysosome localization; neurite development; neurotransmitter secretion; regulation of protein binding; synaptic vesicle exocytosis; synaptic vesicle transport |
| NCBI Summary: | The protein encoded by this gene is a coiled-coil-forming protein that associates with the SNARE (soluble N-ethylmaleimide-sensitive fusion protein attachment protein receptor) complex of proteins and the BLOC-1 (biogenesis of lysosome-related organelles) complex. Biochemical studies have identified additional binding partners. As part of the SNARE complex, it is required for vesicle docking and fusion and regulates neurotransmitter release. The BLOC-1 complex is required for the biogenesis of specialized organelles such as melanosomes and platelet dense granules. Mutations in gene products that form the BLOC-1 complex have been identified in mouse strains that are models of Hermansky-Pudlak syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2012] |
| UniProt Code: | O95295 |
| NCBI GenInfo Identifier: | 41017846 |
| NCBI Gene ID: | 23557 |
| NCBI Accession: | O95295.1 |
| UniProt Secondary Accession: | O95295,Q5SXU8, D3DV56, |
| UniProt Related Accession: | O95295 |
| Molecular Weight: | 15kDa |
| NCBI Full Name: | SNARE-associated protein Snapin |
| NCBI Synonym Full Names: | SNAP associated protein |
| NCBI Official Symbol: | SNAPIN |
| NCBI Official Synonym Symbols: | BLOS7; BORCS3; SNAPAP; BLOC1S7 |
| NCBI Protein Information: | SNARE-associated protein Snapin |
| UniProt Protein Name: | SNARE-associated protein Snapin |
| UniProt Synonym Protein Names: | Biogenesis of lysosome-related organelles complex 1 subunit 7; BLOC-1 subunit 7; Synaptosomal-associated protein 25-binding protein; SNAP-associated protein |
| Protein Family: | SNAPIN protein |
| UniProt Gene Name: | SNAPIN |
 | Western blot analysis of extracts of various cell lines, using SNAPIN antibody (CAB10294) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit (RM00021). Exposure time: 30s. |
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