Anti-SMOX Antibody (CAB11677)
- SKU:
- CAB11677
- Product type:
- Antibody
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Frequently bought together:
Description
| 抗体名: | Anti-SMOX Antibody |
| 抗体コード: | CAB11677 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB |
| 反応性: | Mouse |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-200 of human SMOX (NP_787034.1). |
| 申し込み: | WB |
| 推奨希釈: | WB 1:500 - 1:2000 |
| 反応性: | Mouse |
| ポジティブサンプル: |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-200 of human SMOX (NP_787034.1). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | MQSC ESSG DSAD DPLS RGLR RRGQ PRVV VIGA GLAG LAAA KALL EQGF TDVT VLEA SSHI GGRV QSVK LGHA TFEL GATW IHGS HGNP IYHL AEAN GLLE ETTD GERS VGRI SLYS KNGV ACYL TNHG RRIP KDVV EEFS DLYN EVYN LTQE FFRH DKPV NAES QNSV GVFT REEV RNRI RNDP DDPE ATKR LKLA MIQQ |
| 遺伝子ID: | 54498 |
| Uniprot: | Q9NWM0 |
| セルラーロケーション: | Cytoplasm, Nucleus |
| 計算された分子量: | 20kDa/43kDa/56kDa/59kDa/61kDa/65kDa |
| 観察された分子量: | Refer to Figures |
| 同義語: | SMOX, C20orf16, PAO, PAO-1, PAO1, PAOH, PAOH1, SMO |
| バックグラウンド: | Polyamines are ubiquitous polycationic alkylamines which include spermine, spermidine, putrescine, and agmatine. These molecules participate in a broad range of cellular functions which include cell cycle modulation, scavenging reactive oxygen species, and the control of gene expression. These molecules also play important roles in neurotransmission through their regulation of cell-surface receptor activity, involvement in intracellular signalling pathways, and their putative roles as neurotransmitters. This gene encodes an FAD-containing enzyme that catalyzes the oxidation of spermine to spermadine and secondarily produces hydrogen peroxide. Multiple transcript variants encoding different isoenzymes have been identified for this gene, some of which have failed to demonstrate significant oxidase activity on natural polyamine substrates. The characterized isoenzymes have distinctive biochemical characteristics and substrate specificities, suggesting the existence of additional levels of complexity in polyamine catabolism. |
| UniProt Protein Function: | SMOX: Flavoenzyme which catalyzes the oxidation of spermine to spermidine. Can also use N(1)-acetylspermine and spermidine as substrates, with different affinity depending on the isoform (isozyme) and on the experimental conditions. Plays an important role in the regulation of polyamine intracellular concentration and has the potential to act as a determinant of cellular sensitivity to the antitumor polyamine analogs. May contribute to beta-alanine production via aldehyde dehydrogenase conversion of 3-amino-propanal. Belongs to the flavin monoamine oxidase family. 6 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:EC 1.5.3.16; Oxidoreductase Chromosomal Location of Human Ortholog: 20p13 Cellular Component: cytosol; intracellular membrane-bound organelle; nuclear membrane; nucleoplasm Molecular Function:polyamine oxidase activity Biological Process: polyamine biosynthetic process; polyamine catabolic process |
| NCBI Summary: | Polyamines are ubiquitous polycationic alkylamines which include spermine, spermidine, putrescine, and agmatine. These molecules participate in a broad range of cellular functions which include cell cycle modulation, scavenging reactive oxygen species, and the control of gene expression. These molecules also play important roles in neurotransmission through their regulation of cell-surface receptor activity, involvement in intracellular signalling pathways, and their putative roles as neurotransmitters. This gene encodes an FAD-containing enzyme that catalyzes the oxidation of spermine to spermadine and secondarily produces hydrogen peroxide. Multiple transcript variants encoding different isoenzymes have been identified for this gene, some of which have failed to demonstrate significant oxidase activity on natural polyamine substrates. The characterized isoenzymes have distinctive biochemical characteristics and substrate specificities, suggesting the existence of additional levels of complexity in polyamine catabolism. [provided by RefSeq, Jul 2012] |
| UniProt Code: | Q9NWM0 |
| NCBI GenInfo Identifier: | 50401688 |
| NCBI Gene ID: | 54498 |
| NCBI Accession: | Q9NWM0.1 |
| UniProt Secondary Accession: | Q9NWM0,Q5TE26, Q5TE27, Q6UY28, Q8IX00, Q96LC3, Q96LC4 Q96QT3, A2A2P5, A2A2P6, A8BE87, D3DVZ4, |
| UniProt Related Accession: | Q9NWM0 |
| Molecular Weight: | 62kDa |
| NCBI Full Name: | Spermine oxidase |
| NCBI Synonym Full Names: | spermine oxidase |
| NCBI Official Symbol: | SMOX |
| NCBI Official Synonym Symbols: | PAO; SMO; PAO1; PAOH; PAO-1; PAOH1; C20orf16 |
| NCBI Protein Information: | spermine oxidase |
| UniProt Protein Name: | Spermine oxidase |
| UniProt Synonym Protein Names: | Polyamine oxidase 1; PAO-1; PAOh1 |
| Protein Family: | Spermine oxidase |
| UniProt Gene Name: | SMOX |