Anti-SMARCAL1 Antibody (CAB16524)
- SKU:
- CAB16524
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Frequently bought together:
Description
| 抗体名: | Anti-SMARCAL1 Antibody |
| 抗体コード: | CAB16524 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB |
| 反応性: | Human, Mouse |
| 宿主種: | Rabbit |
| 免疫原: | A synthetic peptide corresponding to a sequence within amino acids 800-900 of human SMARCAL1 (NP_001120679.1). |
| 申し込み: | WB |
| 推奨希釈: | WB 1:500 - 1:2000 |
| 反応性: | Human, Mouse |
| ポジティブサンプル: |
| 免疫原: | A synthetic peptide corresponding to a sequence within amino acids 800-900 of human SMARCAL1 (NP_001120679.1). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | VFAE LFWN PGVL IQAE DRVH RIGQ TSSV GIHY LVAK GTAD DYLW PLIQ EKIK VLAE AGLS ETNF SEMT ESTD YLYK DPKQ QKIY DLFQ KSFE KEGS DMEL L |
| 遺伝子ID: | 50485 |
| Uniprot: | Q9NZC9 |
| セルラーロケーション: | Nucleus |
| 計算された分子量: | 105kDa |
| 観察された分子量: | Refer to figures |
| 同義語: | SMARCAL1, HARP, HHARP |
| バックグラウンド: | The protein encoded by this gene is a member of the SWI/SNF family of proteins. Members of this family have helicase and ATPase activities and are thought to regulate transcription of certain genes by altering the chromatin structure around those genes. The encoded protein shows sequence similarity to the E. coli RNA polymerase-binding protein HepA. Mutations in this gene are a cause of Schimke immunoosseous dysplasia (SIOD), an autosomal recessive disorder with the diagnostic features of spondyloepiphyseal dysplasia, renal dysfunction, and T-cell immunodeficiency. |
| UniProt Protein Function: | SMARCAL1: ATP-dependent annealing helicase that catalyzes the rewinding of the stably unwound DNA. Rewinds single-stranded DNA bubbles that are stably bound by replication protein A (RPA). Acts throughout the genome to reanneal stably unwound DNA, performing the opposite reaction of many enzymes, such as helicases and polymerases, that unwind DNA. Defects in SMARCAL1 are a cause of Schimke immuno-osseous dysplasia (SIOD). SIOD causes spondyloepiphyseal dysplasia, renal dysfunction and T-cell immunodeficiency. Approximately half of all patients also exhibit hyperthyroidism, while around half also exhibit episodal cerebral ischema. Belongs to the SNF2/RAD54 helicase family. SMARCAL1 subfamily. |
| UniProt Protein Details: | Protein type:EC 3.6.4.-; EC 3.6.1.-; Helicase Chromosomal Location of Human Ortholog: 2q35 Cellular Component: nucleoplasm; DNA replication factor A complex; nucleus Molecular Function:DNA-dependent ATPase activity; protein binding; DNA binding; helicase activity; ATP binding Biological Process: regulation of transcription from RNA polymerase II promoter; DNA strand renaturation; chromatin modification; DNA repair; response to DNA damage stimulus; DNA metabolic process; replication fork processing Disease: Immunoosseous Dysplasia, Schimke Type |
| NCBI Summary: | The protein encoded by this gene is a member of the SWI/SNF family of proteins. Members of this family have helicase and ATPase activities and are thought to regulate transcription of certain genes by altering the chromatin structure around those genes. The encoded protein shows sequence similarity to the E. coli RNA polymerase-binding protein HepA. Mutations in this gene are a cause of Schimke immunoosseous dysplasia (SIOD), an autosomal recessive disorder with the diagnostic features of spondyloepiphyseal dysplasia, renal dysfunction, and T-cell immunodeficiency. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q9NZC9 |
| NCBI GenInfo Identifier: | 60390962 |
| NCBI Gene ID: | 50485 |
| NCBI Accession: | Q9NZC9.1 |
| UniProt Related Accession: | Q9NZC9 |
| Molecular Weight: | 105kDa |
| NCBI Full Name: | SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A-like protein 1 |
| NCBI Synonym Full Names: | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a like 1 |
| NCBI Official Symbol: | SMARCAL1 |
| NCBI Official Synonym Symbols: | HARP; HHARP |
| NCBI Protein Information: | SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A-like protein 1 |
| UniProt Protein Name: | SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A-like protein 1 |
| UniProt Synonym Protein Names: | HepA-related protein; hHARP; Sucrose nonfermenting protein 2-like 1 |
| UniProt Gene Name: | SMARCAL1 |
| UniProt Entry Name: | SMAL1_HUMAN |
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