Anti-SLURP1 Antibody (CAB7123)
- SKU:
- CAB7123
- Product type:
- Antibody
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Frequently bought together:
Description
| 抗体名: | Anti-SLURP1 Antibody |
| 抗体コード: | CAB7123 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB |
| 反応性: | Mouse |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-103 of human SLURP1 (NP_065160.1). |
| 申し込み: | WB |
| 推奨希釈: | WB 1:500 - 1:2000 |
| 反応性: | Mouse |
| ポジティブサンプル: | Mouse heart |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-103 of human SLURP1 (NP_065160.1). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | MASR WAVQ LLLV AAWS MGCG EALK CYTC KEPM TSAS CRTI TRCK PEDT ACMT TLVT VEAE YPFN QSPV VTRS CSSS CVAT DPDS IGAA HLIF CCFR DLCN SEL |
| 遺伝子ID: | 57152 |
| Uniprot: | P55000 |
| セルラーロケーション: | Secreted |
| 計算された分子量: | 11kDa |
| 観察された分子量: | 11kDa |
| 同義語: | SLURP1, ANUP, ARS, ArsB, LY6LS, MDM |
| バックグラウンド: | The protein encoded by this gene is a member of the Ly6/uPAR family but lacks a GPI-anchoring signal sequence. It is thought that this secreted protein contains antitumor activity. Mutations in this gene have been associated with Mal de Meleda, a rare autosomal recessive skin disorder. This gene maps to the same chromosomal region as several members of the Ly6/uPAR family of glycoprotein receptors. |
| UniProt Protein Function: | SLURP1: Has an antitumor activity. Was found to be a marker of late differentiation of the skin. Implicated in maintaining the physiological and structural integrity of the keratinocyte layers of the skin. Defects in SLURP1 are a cause of Mal de Meleda (MDM); also known as keratosis palmoplantaris transgradiens of Siemens. MDM is a rare autosomal recessive skin disorder, characterized by diffuse transgressive palmoplantar keratoderma with keratotic lesions extending onto the dorsa of the hands and the feet (transgrediens). Patients may have hyperhidrosis. Other features include perioral erythema, lichenoid plaques on the knees and the elbows, and nail abnormalities. |
| UniProt Protein Details: | Protein type:Secreted, signal peptide; Secreted Chromosomal Location of Human Ortholog: 8q24.3 Cellular Component: extracellular space; extracellular region Molecular Function:cytokine activity Biological Process: cell activation; neuromuscular process controlling posture; locomotory behavior; cell adhesion Disease: Mal De Meleda |
| NCBI Summary: | The protein encoded by this gene is a member of the Ly6/uPAR family but lacks a GPI-anchoring signal sequence. It is thought that this secreted protein contains antitumor activity. Mutations in this gene have been associated with Mal de Meleda, a rare autosomal recessive skin disorder. This gene maps to the same chromosomal region as several members of the Ly6/uPAR family of glycoprotein receptors. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P55000 |
| NCBI GenInfo Identifier: | 3287957 |
| NCBI Gene ID: | 57152 |
| NCBI Accession: | P55000.2 |
| UniProt Secondary Accession: | P55000,Q53YJ6, Q6PUA6, Q92483, |
| UniProt Related Accession: | P55000 |
| Molecular Weight: | 11kDa |
| NCBI Full Name: | Secreted Ly-6/uPAR-related protein 1 |
| NCBI Synonym Full Names: | secreted LY6/PLAUR domain containing 1 |
| NCBI Official Symbol: | SLURP1 |
| NCBI Official Synonym Symbols: | ARS; MDM; ANUP; ArsB; LY6LS |
| NCBI Protein Information: | secreted Ly-6/uPAR-related protein 1; SLURP-1; ARS(component B)-81/S; anti-neoplastic urinary protein; lymphocyte antigen 6-like secreted; secreted Ly6/uPAR related protein 1 |
| UniProt Protein Name: | Secreted Ly-6/uPAR-related protein 1 |
| UniProt Synonym Protein Names: | ARS component B; ARS(component B)-81/S; Anti-neoplastic urinary protein; ANUP |
| Protein Family: | Secreted Ly-6/uPAR-related protein |
| UniProt Gene Name: | SLURP1 |
| UniProt Entry Name: | SLUR1_HUMAN |
 | Western blot analysis of extracts of mouse heart, using SLURP1 antibody (CAB7123) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s. |
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