Anti-SLCO1A2 Antibody (CAB8452)
- SKU:
- CAB8452
- Product type:
- Antibody
- Application:
- WB
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Signal Transduction
Frequently bought together:
Description
| 抗体名: | Anti-SLCO1A2 Antibody |
| 抗体コード: | CAB8452 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB |
| 反応性: | Human, Mouse, Rat |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 606-670 of human SLCO1A2 (NP_602307.1). |
| 申し込み: | WB |
| 推奨希釈: | WB 1:500 - 1:2000 |
| 反応性: | Human, Mouse, Rat |
| ポジティブサンプル: | MCF7, HeLa, Mouse brain, Rat brain |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 606-670 of human SLCO1A2 (NP_602307.1). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | AALR GSSF VPAL IILI LLRK CHLP GENA SSGT ELIE TKVK GKEN ECKD IYQK STVL KDDE LKTK L |
| 遺伝子ID: | 6579 |
| Uniprot: | P46721 |
| セルラーロケーション: | Cell membrane, Multi-pass membrane protein |
| 計算された分子量: | 64kDa/74kDa |
| 観察された分子量: | 60kDa |
| 同義語: | SLCO1A2, OATP, OATP-A, OATP1A2, SLC21A3 |
| バックグラウンド: | This gene encodes a sodium-independent transporter which mediates cellular uptake of organic ions in the liver. Its substrates include bile acids, bromosulphophthalein, and some steroidal compounds. The protein is a member of the SLC21A family of solute carriers. Alternative splicing of this gene results in multiple transcript variants. |
| UniProt Protein Function: | SLCO1A2: Mediates the Na(+)-independent transport of organic anions such as sulfobromophthalein (BSP) and conjugated (taurocholate) and unconjugated (cholate) bile acids. Selectively inhibited by the grapefruit juice component naringin. Belongs to the organo anion transporter (TC 2.A.60) family. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Membrane protein, multi-pass; Membrane protein, integral; Transporter, SLC family; Transporter Chromosomal Location of Human Ortholog: 12p12 Cellular Component: integral to membrane; plasma membrane Molecular Function:organic anion transmembrane transporter activity Biological Process: bile acid and bile salt transport; sodium-independent organic anion transport; bile acid metabolic process; transmembrane transport; organic anion transport |
| NCBI Summary: | This gene encodes a sodium-independent transporter which mediates cellular uptake of organic ions in the liver. Its substrates include bile acids, bromosulphophthalein, and some steroidal compounds. The protein is a member of the SLC21A family of solute carriers. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Dec 2008] |
| UniProt Code: | P46721 |
| NCBI GenInfo Identifier: | 10835099 |
| NCBI Gene ID: | 6579 |
| NCBI Accession: | NP_066580.1 |
| UniProt Secondary Accession: | P46721,Q9UGP7, Q9UL38, |
| UniProt Related Accession: | P46721 |
| Molecular Weight: | 74,145 Da |
| NCBI Full Name: | solute carrier organic anion transporter family member 1A2 |
| NCBI Synonym Full Names: | solute carrier organic anion transporter family, member 1A2 |
| NCBI Official Symbol: | SLCO1A2 |
| NCBI Official Synonym Symbols: | OATP; OATP-A; OATP1A2; SLC21A3 |
| NCBI Protein Information: | solute carrier organic anion transporter family member 1A2; OATP-1; solute carrier family 21 member 3; organic anion transporting polypeptide A; organic anion-transporting polypeptide 1; sodium-independent organic anion transporter; solute carrier family |
| UniProt Protein Name: | Solute carrier organic anion transporter family member 1A2 |
| UniProt Synonym Protein Names: | OATP-A; Organic anion-transporting polypeptide 1; OATP-1; Sodium-independent organic anion transporter; Solute carrier family 21 member 3 |
| UniProt Gene Name: | SLCO1A2 |
| UniProt Entry Name: | SO1A2_HUMAN |
 | Western blot analysis of extracts of various cell lines, using SLCO1A2 antibody (CAB8452) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 10s. |
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