Anti-SLC7A8 Antibody (CAB14861)
- SKU:
- CAB14861
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Signal Transduction
Frequently bought together:
Description
| 抗体名: | Anti-SLC7A8 Antibody |
| 抗体コード: | CAB14861 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB |
| 反応性: | Human |
| 宿主種: | Rabbit |
| 免疫原: | A synthetic peptide corresponding to a sequence within amino acids 150-250 of human SLC7A8 (NP_036376.2). |
| 申し込み: | WB |
| 推奨希釈: | WB 1:500 - 1:2000 |
| 反応性: | Human |
| ポジティブサンプル: | HeLa, A375 |
| 免疫原: | A synthetic peptide corresponding to a sequence within amino acids 150-250 of human SLC7A8 (NP_036376.2). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | LFPT CFPP ESGL RLLA AICL LLLT WVNC SSVR WATR VQDI FTAG KLLA LALI IIMG IVQI CKGE YFWL EPKN AFEN FQEP DIGL VALA FLQG SFAY GGWN F |
| 遺伝子ID: | 23428 |
| Uniprot: | Q9UHI5 |
| セルラーロケーション: | Basolateral cell membrane, Cytoplasm, Multi-pass membrane protein |
| 計算された分子量: | 34kDa/37kDa/48kDa/58kDa |
| 観察された分子量: | 58kDa |
| 同義語: | SLC7A8, LAT2, LPI-PC1 |
| バックグラウンド: |
| UniProt Protein Function: | SLC7A8: Sodium-independent, high-affinity transport of small and large neutral amino acids such as alanine, serine, threonine, cysteine, phenylalanine, tyrosine, leucine, arginine and tryptophan, when associated with SLC3A2/4F2hc. Acts as an amino acid exchanger. Has higher affinity for L-phenylalanine than LAT1 but lower affinity for glutamine and serine. L-alanine is transported at physiological concentrations. Plays a role in basolateral (re)absorption of neutral amino acids. Involved in the uptake of methylmercury (MeHg) when administered as the L-cysteine or D,L-homocysteine complexes, and hence plays a role in metal ion homeostasis and toxicity. Involved in the cellular activity of small molecular weight nitrosothiols, via the stereoselective transport of L-nitrosocysteine (L-CNSO) across the transmembrane. Plays an essential role in the reabsorption of neutral amino acids from the epithelial cells to the bloodstream in the kidney. Belongs to the amino acid-polyamine-organocation (APC) superfamily. L-type amino acid transporter (LAT) (TC 2.A.3.8) family. |
| UniProt Protein Details: | Protein type:Transporter, SLC family; Membrane protein, multi-pass; Transporter; Membrane protein, integral Chromosomal Location of Human Ortholog: 14q11.2 Cellular Component: basolateral plasma membrane; cytoplasm; integral to plasma membrane; plasma membrane Molecular Function:amino acid transmembrane transporter activity; antiporter activity; L-amino acid transmembrane transporter activity; neutral amino acid transmembrane transporter activity; organic cation transmembrane transporter activity; peptide antigen binding; protein binding; toxin transporter activity Biological Process: amino acid metabolic process; amino acid transport; blood coagulation; ion transport; leukocyte migration; metal ion homeostasis; neutral amino acid transport; organic cation transport; response to toxin; transmembrane transport; transport |
| UniProt Code: | Q9UHI5 |
| NCBI GenInfo Identifier: | 33286428 |
| NCBI Gene ID: | 23428 |
| NCBI Accession: | NP_036376 |
| UniProt Secondary Accession: | Q9UHI5,Q86U05, Q9UKQ6, Q9UKQ7, Q9UKQ8, Q9Y445, B2R8Q4 B4DKT4, B4DTV6, D3DS46, F2Z2J4, |
| UniProt Related Accession: | Q9UHI5 |
| Molecular Weight: | 48,283 Da |
| NCBI Full Name: | large neutral amino acids transporter small subunit 2 isoform a |
| NCBI Synonym Full Names: | solute carrier family 7 (amino acid transporter light chain, L system), member 8 |
| NCBI Official Symbol: | SLC7A8 |
| NCBI Official Synonym Symbols: | LAT2; LPI-PC1 |
| NCBI Protein Information: | large neutral amino acids transporter small subunit 2 |
| UniProt Protein Name: | Large neutral amino acids transporter small subunit 2 |
| UniProt Synonym Protein Names: | L-type amino acid transporter 2; hLAT2; Solute carrier family 7 member 8 |
| Protein Family: | Linker for activation of T-cells family |
| UniProt Gene Name: | SLC7A8 |
| UniProt Entry Name: | LAT2_HUMAN |
 | Western blot analysis of extracts of various cell lines, using SLC7A8 antibody (CAB14861) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 10s. |
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