| UniProt Protein Function: | Involved in the sodium-independent uptake of dibasic amino acids and sodium-dependent uptake of some neutral amino acids. Requires coexpression with SLC3A2/4F2hc to mediate the uptake of arginine, leucine and glutamine. Plays a role in nitric oxide synthesis in human umbilical vein endothelial cells (HUVECs) via transport of L-arginine. Involved in the transport of L-arginine in monocytes. |
| NCBI Summary: | The protein encoded by this gene is the light subunit of a cationic amino acid transporter. This sodium-independent transporter is formed when the light subunit encoded by this gene dimerizes with the heavy subunit transporter protein SLC3A2. This transporter is found in epithelial cell membranes where it transfers cationic and large neutral amino acids from the cell to the extracellular space. Defects in this gene are a cause of lysinuric protein intolerance (LPI). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2011] |
| UniProt Code: | Q9UM01 |
| NCBI GenInfo Identifier: | 186910306 |
| NCBI Gene ID: | 9056 |
| NCBI Accession: | NP_001119577.1 |
| UniProt Related Accession: | Q9UM01 |
| Molecular Weight: | |
| NCBI Full Name: | Y+L amino acid transporter 1 |
| NCBI Synonym Full Names: | solute carrier family 7 member 7 |
| NCBI Official Symbol: | SLC7A7 |
| NCBI Official Synonym Symbols: | LPI; LAT3; MOP-2; Y+LAT1; y+LAT-1 |
| NCBI Protein Information: | Y+L amino acid transporter 1 |
| UniProt Protein Name: | Y+L amino acid transporter 1 |
| UniProt Synonym Protein Names: | Monocyte amino acid permease 2; MOP-2; Solute carrier family 7 member 7; y(+)L-type amino acid transporter 1; Y+LAT1; y+LAT-1 |
| Protein Family: | Y+L amino acid transporter |
| UniProt Gene Name: | SLC7A7 |
