Anti-SLC6A5 Antibody (CAB11647)
- SKU:
- CAB11647
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Neuroscience
Frequently bought together:
Description
| 抗体名: | Anti-SLC6A5 Antibody |
| 抗体コード: | CAB11647 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB |
| 反応性: | Human, Mouse, Rat |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-200 of human SLC6A5 (NP_004202.3). |
| 申し込み: | WB |
| 推奨希釈: | WB 1:500 - 1:2000 |
| 反応性: | Human, Mouse, Rat |
| ポジティブサンプル: | SH-SY5Y, U-937, U-87MG, U-251MG, Mouse brain, Mouse liver, Rat brain |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-200 of human SLC6A5 (NP_004202.3). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | MDCS APKE MNKL PANS PEAA AAQG HPDG PCAP RTSP EQEL PAAA APPP PRVP RSAS TGAQ TFQS ADAR ACEA ERPG VGSC KLSS PRAQ AASA ALRD LREA QGAQ ASPP PGSS GPGN ALHC KIPF LRGP EGDA NVSV GKGT LERN NTPV VGWV NMSQ STVV LGTD GITS VLPG SVAT VATQ EDEQ GDEN KARG NWSS KLDF |
| 遺伝子ID: | 9152 |
| Uniprot: | Q9Y345 |
| セルラーロケーション: | Membrane, Multi-pass membrane protein |
| 計算された分子量: | 87kDa |
| 観察された分子量: | 60kDa |
| 同義語: | SLC6A5, GLYT-2, GLYT2, HKPX3, NET1 |
| バックグラウンド: | This gene encodes a sodium- and chloride-dependent glycine neurotransmitter transporter. This integral membrane glycoprotein is responsible for the clearance of extracellular glycine during glycine-mediated neurotransmission. This protein is found in glycinergic axons and maintains a high presynaptic pool of neurotransmitter at glycinergic synapses. Mutations in this gene cause hyperekplexia; a heterogenous neurological disorder characterized by exaggerated startle responses and neonatal apnea. Two transcript variants encoding different isoforms have been found for this gene. |
| UniProt Protein Function: | SLC6A5: Terminates the action of glycine by its high affinity sodium-dependent reuptake into presynaptic terminals. May be responsible for the termination of neurotransmission at strychnine-sensitive glycinergic synapses. Defects in SLC6A5 are the cause of hyperekplexia type 3 (HKPX3). HKPX3 is a neurologic disorder characterized by neonatal hypertonia, an exaggerated startle response to tactile or acoustic stimuli, and life- threatening neonatal apnea episodes. Notably, in some cases, symptoms resolved in the first year of life. Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. SLC6A5 subfamily. |
| UniProt Protein Details: | Protein type:Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family Chromosomal Location of Human Ortholog: 11p15.1 Cellular Component: integral to membrane; integral to plasma membrane; plasma membrane Molecular Function:glycine:sodium symporter activity Biological Process: synaptic transmission; synaptic transmission, glycinergic; transport Disease: Hyperekplexia 3 |
| NCBI Summary: | This gene encodes a sodium- and chloride-dependent glycine neurotransmitter transporter. This integral membrane glycoprotein is responsible for the clearance of extracellular glycine during glycine-mediated neurotransmission. This protein is found in glycinergic axons and maintains a high presynaptic pool of neurotransmitter at glycinergic synapses. Mutations in this gene cause hyperekplexia; a heterogenous neurological disorder characterized by exaggerated startle responses and neonatal apnea. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2016] |
| UniProt Code: | Q9Y345 |
| NCBI GenInfo Identifier: | 296452967 |
| NCBI Gene ID: | 9152 |
| NCBI Accession: | Q9Y345.3 |
| UniProt Secondary Accession: | Q9Y345,O95288, Q4VAM7, Q9BX77, |
| UniProt Related Accession: | Q9Y345 |
| Molecular Weight: | 87kDa |
| NCBI Full Name: | Sodium- and chloride-dependent glycine transporter 2 |
| NCBI Synonym Full Names: | solute carrier family 6 member 5 |
| NCBI Official Symbol: | SLC6A5 |
| NCBI Official Synonym Symbols: | NET1; GLYT2; HKPX3; GLYT-2 |
| NCBI Protein Information: | sodium- and chloride-dependent glycine transporter 2 |
| UniProt Protein Name: | Sodium- and chloride-dependent glycine transporter 2 |
| UniProt Synonym Protein Names: | Solute carrier family 6 member 5 |
| Protein Family: | Sodium- and chloride-dependent glycine transporter |
| UniProt Gene Name: | SLC6A5 |
 | Western blot analysis of extracts of various cell lines, using SLC6A5 antibody (CAB11647) at 1:3000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 5s. |
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