Anti-SLC6A11 Antibody (CAB11702)
- SKU:
- CAB11702
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Neuroscience
Frequently bought together:
Description
| 抗体名: | Anti-SLC6A11 Antibody |
| 抗体コード: | CAB11702 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB |
| 反応性: | Human, Mouse, Rat |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-60 of human SLC6A11 (NP_055044.1). |
| 申し込み: | WB |
| 推奨希釈: | WB 1:500 - 1:2000 |
| 反応性: | Human, Mouse, Rat |
| ポジティブサンプル: | SH-SY5Y, LO2, Mouse brain, Rat brain |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-60 of human SLC6A11 (NP_055044.1). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | MTAE KALP LGNG KAAE EARE SEAP GGGC SSGG AAPA RHPR VKRD KAVH ERGH WNNK VEFV |
| 遺伝子ID: | 6538 |
| Uniprot: | P48066 |
| セルラーロケーション: | Membrane, Multi-pass membrane protein |
| 計算された分子量: | 23kDa/70kDa |
| 観察された分子量: | 62kDa |
| 同義語: | SLC6A11, GAT-3, GAT3, GAT4 |
| バックグラウンド: | The protein encoded by this gene is a sodium-dependent transporter that uptakes gamma-aminobutyric acid (GABA), an inhibitory neurotransmitter, which ends the GABA neurotransmission. Defects in this gene may result in epilepsy, behavioral problems, or intellectual problems. Two transcript variants encoding different isoforms have been found for this gene. |
| UniProt Protein Function: | SLC6A11: Terminates the action of GABA by its high affinity sodium-dependent reuptake into presynaptic terminals. Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. SLC6A11 subfamily. |
| UniProt Protein Details: | Protein type:Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family Chromosomal Location of Human Ortholog: 3p25.3 Cellular Component: integral to membrane; integral to plasma membrane; plasma membrane Molecular Function:gamma-aminobutyric acid:sodium symporter activity; transporter activity Biological Process: transport |
| NCBI Summary: | The protein encoded by this gene is a sodium-dependent transporter that uptakes gamma-aminobutyric acid (GABA), an inhibitory neurotransmitter, which ends the GABA neurotransmission. Defects in this gene may result in epilepsy, behavioral problems, or intellectual problems. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2015] |
| UniProt Code: | P48066 |
| NCBI GenInfo Identifier: | 1352531 |
| NCBI Gene ID: | 6538 |
| NCBI Accession: | P48066.1 |
| UniProt Secondary Accession: | P48066,Q8IYC9, B2R6U6, |
| UniProt Related Accession: | P48066 |
| Molecular Weight: | 71kDa |
| NCBI Full Name: | Sodium- and chloride-dependent GABA transporter 3 |
| NCBI Synonym Full Names: | solute carrier family 6 member 11 |
| NCBI Official Symbol: | SLC6A11 |
| NCBI Official Synonym Symbols: | GAT3; GAT4; GAT-3 |
| NCBI Protein Information: | sodium- and chloride-dependent GABA transporter 3 |
| UniProt Protein Name: | Sodium- and chloride-dependent GABA transporter 3 |
| UniProt Synonym Protein Names: | Solute carrier family 6 member 11 |
| Protein Family: | Sodium- and chloride-dependent GABA transporter |
| UniProt Gene Name: | SLC6A11 |
 | Western blot analysis of extracts of various cell lines, using SLC6A11 antibody (CAB11702) at 1:3000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 5s. |
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