Anti-SLC5A8 Antibody (CAB18677)
- SKU:
- CAB18677
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
Frequently bought together:
Description
| 抗体名: | Anti-SLC5A8 Antibody |
| 抗体コード: | CAB18677 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB |
| 反応性: | Human |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant protein of human SLC5A8. |
| 申し込み: | WB |
| 推奨希釈: | WB 1:500 - 1:2000 |
| 反応性: | Human |
| ポジティブサンプル: |
| 免疫原: | Recombinant protein of human SLC5A8. |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | Email for sequence |
| 遺伝子ID: | 160728 |
| Uniprot: | Q8N695 |
| セルラーロケーション: | |
| 計算された分子量: | |
| 観察された分子量: | Refer to figures |
| 同義語: | |
| バックグラウンド: |
| UniProt Protein Function: | SLC5A8: Acts as an electrogenic sodium (Na(+)) and chloride (Cl-)-dependent sodium-coupled solute transporter, including transport of monocarboxylates (short-chain fatty acids including L-lactate, D-lactate, pyruvate, acetate, propionate, valerate and butyrate), lactate, mocarboxylate drugs (nicotinate, benzoate, salicylate and 5-aminosalicylate) and ketone bodies (beta-D- hydroxybutyrate, acetoacetate and alpha-ketoisocaproate), with a Na(+):substrate stoichiometry of between 4:1 and 2:1. Catalyzes passive carrier mediated diffusion of iodide. Mediates iodide transport from the thyrocyte into the colloid lumen through the apical membrane. May be responsible for the absorption of D- lactate and monocarboxylate drugs from the intestinal tract. Acts as a tumor suppressor, suppressing colony formation in colon cancer, prostate cancer and glioma cell lines. May play a critical role in the entry of L-lactate and ketone bodies into neurons by a process driven by an electrochemical Na(+) gradient and hence contribute to the maintenance of the energy status and function of neurons. Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family. |
| UniProt Protein Details: | Protein type:Tumor suppressor; Transporter; Membrane protein, multi-pass; Transporter, SLC family; Membrane protein, integral; Apoptosis Chromosomal Location of Human Ortholog: 12q23.1 Cellular Component: integral to plasma membrane; plasma membrane Molecular Function:monocarboxylic acid transmembrane transporter activity; passive transmembrane transporter activity; symporter activity Biological Process: ion transport |
| NCBI Summary: | SLC5A8 has been shown to transport iodide by a passive mechanism (Rodriguez et al., 2002 [PubMed 12107270]) and monocarboxylates and short-chain fatty acids by a sodium-coupled mechanism (Gopal et al., 2004 [PubMed 15322102]). In kidney, SLC5A8 functions as a high-affinity sodium-coupled lactate transporter involved in reabsorption of lactate and maintenance of blood lactate levels (Thangaraju et al., 2006 [PubMed 16873376]).[supplied by OMIM, Dec 2008] |
| UniProt Code: | Q8N695 |
| NCBI GenInfo Identifier: | 296452898 |
| NCBI Gene ID: | 160728 |
| NCBI Accession: | Q8N695.2 |
| UniProt Secondary Accession: | Q8N695,Q2TB99, Q7Z2H9, |
| UniProt Related Accession: | Q8N695 |
| Molecular Weight: | 66,578 Da |
| NCBI Full Name: | Sodium-coupled monocarboxylate transporter 1 |
| NCBI Synonym Full Names: | solute carrier family 5 member 8 |
| NCBI Official Symbol: | SLC5A8 |
| NCBI Official Synonym Symbols: | AIT; SMCT; SMCT1 |
| NCBI Protein Information: | sodium-coupled monocarboxylate transporter 1 |
| UniProt Protein Name: | Sodium-coupled monocarboxylate transporter 1 |
| UniProt Synonym Protein Names: | Apical iodide transporter; Electrogenic sodium monocarboxylate cotransporter; Sodium iodide-related cotransporter; Solute carrier family 5 member 8 |
| Protein Family: | Sodium-coupled monocarboxylate transporter |
| UniProt Gene Name: | SLC5A8 |
| UniProt Entry Name: | SC5A8_HUMAN |