Anti-SLC4A8 Antibody (CAB14825)
- SKU:
- CAB14825
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Signal Transduction
Frequently bought together:
Description
| 抗体名: | Anti-SLC4A8 Antibody |
| 抗体コード: | CAB14825 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB |
| 反応性: | Human, Mouse, Rat |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-90 of human SLC4A8 (NP_001035049.1). |
| 申し込み: | WB |
| 推奨希釈: | WB 1:500 - 1:2000 |
| 反応性: | Human, Mouse, Rat |
| ポジティブサンプル: | U-87MG, SH-SY5Y, Mouse lung, Rat kidney |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-90 of human SLC4A8 (NP_001035049.1). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | MPAA GSNE PDGV LSYQ RPDE EAVV DQGG TSTI LNIH YEKE ELEG HRTL YVGV RMPL GRQS HRHH RTHG QKHR RRGR GKGA SQGE EGLE AL |
| 遺伝子ID: | 9498 |
| Uniprot: | Q2Y0W8 |
| セルラーロケーション: | Membrane, Multi-pass membrane protein |
| 計算された分子量: | 71kDa/77kDa/83kDa/111kDa/117kDa/120kDa/122kDa |
| 観察された分子量: | 123kDa |
| 同義語: | SLC4A8, NBC3, NDCBE |
| バックグラウンド: | The protein encoded by this gene is a membrane protein that functions to transport sodium and bicarbonate ions across the cell membrane. The encoded protein is important for pH regulation in neurons. The activity of this protein can be inhibited by 4, 4'-Di-isothiocyanatostilbene-2, 2'-disulfonic acid (DIDS). Several transcript variants encoding different isoforms have been found for this gene. |
| UniProt Protein Function: | SLC4A8: Mediates electroneutral sodium- and carbonate-dependent chloride-HCO3(-) exchange with a Na(+):HCO3(-) stoichiometry of 2:1. Plays a major role in pH regulation in neurons. May be involved in cell pH regulation by transporting HCO3(-) from blood to cell. Enhanced expression in severe acid stress could be important for cell survival by mediating the influx of HCO3(-) into the cells. Also mediates lithium-dependent HCO3(-) cotransport. May be regulated by osmolarity. Belongs to the anion exchanger (TC 2.A.31) family. 7 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Transporter, SLC family; Membrane protein, integral; Transporter; Membrane protein, multi-pass Chromosomal Location of Human Ortholog: 12q13.13 Cellular Component: neuron projection; integral to plasma membrane; plasma membrane Molecular Function:inorganic anion exchanger activity; sodium:bicarbonate symporter activity Biological Process: bicarbonate transport; regulation of intracellular pH; ion transport; transmembrane transport |
| NCBI Summary: | The protein encoded by this gene is a membrane protein that functions to transport sodium and bicarbonate ions across the cell membrane. The encoded protein is important for pH regulation in neurons. The activity of this protein can be inhibited by 4,4'-Di-isothiocyanatostilbene-2,2'-disulfonic acid (DIDS). Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2012] |
| UniProt Code: | Q2Y0W8 |
| NCBI GenInfo Identifier: | 90403614 |
| NCBI Gene ID: | 9498 |
| NCBI Accession: | NP_001035049.1 |
| UniProt Secondary Accession: | Q2Y0W8,O94843, O95233, Q004B4, Q8N3U2, Q8TC60, Q9UKX8 A0MMZ1, B4DHY0, E7EML0, F5GZ31, F5H7F5, |
| UniProt Related Accession: | Q2Y0W8 |
| Molecular Weight: | 122938 |
| NCBI Full Name: | electroneutral sodium bicarbonate exchanger 1 isoform a |
| NCBI Synonym Full Names: | solute carrier family 4, sodium bicarbonate cotransporter, member 8 |
| NCBI Official Symbol: | SLC4A8 |
| NCBI Official Synonym Symbols: | NBC3; NDCBE |
| NCBI Protein Information: | electroneutral sodium bicarbonate exchanger 1 |
| UniProt Protein Name: | Electroneutral sodium bicarbonate exchanger 1 |
| UniProt Synonym Protein Names: | Electroneutral Na(+)-driven Cl-HCO3 exchanger; Solute carrier family 4 member 8; k-NBC3 |
| UniProt Gene Name: | SLC4A8 |
| UniProt Entry Name: | S4A8_HUMAN |
 | Western blot analysis of extracts of various cell lines, using SLC4A8 antibody (CAB14825) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 1s. |
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