Anti-SLC46A1 Antibody (CAB7397)
- SKU:
- CAB7397
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
Frequently bought together:
Description
| 抗体名: | Anti-SLC46A1 Antibody |
| 抗体コード: | CAB7397 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB |
| 反応性: | Human |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-130 of human SLC46A1 (NP_001229295.1). |
| 申し込み: | WB |
| 推奨希釈: | WB 1:500 - 1:2000 |
| 反応性: | Human |
| ポジティブサンプル: |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-130 of human SLC46A1 (NP_001229295.1). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | MEGS ASPP EKPR ARPA AAVL CRGP VEPL VFLA NFAL VLQG PLTT QYLW HRFS ADLG YNGT RQRG GCSN RSAD PTMQ EVET LTSH WTLY MNVG GFLV GLFS STLL GAWS DSVG RRPL LVLA SLGL LLQA LV |
| 遺伝子ID: | 113235 |
| Uniprot: | Q96NT5 |
| セルラーロケーション: | Apical cell membrane, Cytoplasm, Multi-pass membrane protein |
| 計算された分子量: | 46kDa/49kDa |
| 観察された分子量: | Refer to figures |
| 同義語: | SLC46A1, G21, HCP1, PCFT |
| バックグラウンド: | This gene encodes a transmembrane proton-coupled folate transporter protein that facilitates the movement of folate and antifolate substrates across cell membranes, optimally in acidic pH environments. This protein is also expressed in the brain and choroid plexus where it transports folates into the central nervous system. This protein further functions as a heme transporter in duodenal enterocytes, and potentially in other tissues like liver and kidney. Its localization to the apical membrane or cytoplasm of intestinal cells is modulated by dietary iron levels. Mutations in this gene are associated with autosomal recessive hereditary folate malabsorption disease. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. |
| UniProt Protein Function: | SLC46A1: Has been shown to act both as an intestinal proton- coupled high-affinity folate transporter and as an intestinal heme transporter which mediates heme uptake from the gut lumen into duodenal epithelial cells. The iron is then released from heme and may be transported into the bloodstream. Dietary heme iron is an important nutritional source of iron. Shows a higher affinity for folate than heme. Defects in SLC46A1 are the cause of hereditary folate malabsorption (HFM). HFM is a rare autosomal recessive disorder characterized by impaired intestinal folate absorption with folate deficiency resulting in anemia, hypoimmunoglobulinemia with recurrent infections, and recurrent or chronic diarrhea. In many patients, neurological abnormalities such as seizures or mental retardation become apparent during early childhood, attributed to impaired transport of folates into the central nervous system. When diagnosed early, the disorder can be treated by administration of folate. If untreated, it can be fatal and, if treatment is delayed, the neurological defects can become permanent. Belongs to the major facilitator superfamily. SLC46A family. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Membrane protein, multi-pass; Transporter, iron; Membrane protein, integral; Transporter; Transporter, ion channel Chromosomal Location of Human Ortholog: 17q11.2 Cellular Component: apical plasma membrane; brush border membrane; cell surface; cytoplasm; integral to membrane; plasma membrane Molecular Function:folic acid binding; folic acid transporter activity; heme transporter activity; hydrogen ion transmembrane transporter activity; methotrexate transporter activity Biological Process: cellular iron ion homeostasis; folic acid metabolic process; folic acid transport; heme transport; methotrexate transport Disease: Folate Malabsorption, Hereditary |
| NCBI Summary: | This gene encodes a transmembrane proton-coupled folate transporter protein that facilitates the movement of folate and antifolate substrates across cell membranes, optimally in acidic pH environments. This protein is also expressed in the brain and choroid plexus where it transports folates into the central nervous system. This protein further functions as a heme transporter in duodenal enterocytes, and potentially in other tissues like liver and kidney. Its localization to the apical membrane or cytoplasm of intestinal cells is modulated by dietary iron levels. Mutations in this gene are associated with autosomal recessive hereditary folate malabsorption disease. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Aug 2013] |
| UniProt Code: | Q96NT5 |
| NCBI GenInfo Identifier: | 31543204 |
| NCBI Gene ID: | 113235 |
| NCBI Accession: | NP_542400.2 |
| UniProt Secondary Accession: | Q96NT5,Q1HE20, Q86T92, Q8TEG3, Q96FL0, |
| UniProt Related Accession: | Q96NT5 |
| Molecular Weight: | |
| NCBI Full Name: | proton-coupled folate transporter isoform 1 |
| NCBI Synonym Full Names: | solute carrier family 46 member 1 |
| NCBI Official Symbol: | SLC46A1 |
| NCBI Official Synonym Symbols: | G21; HCP1; PCFT |
| NCBI Protein Information: | proton-coupled folate transporter |
| UniProt Protein Name: | Proton-coupled folate transporter |
| UniProt Synonym Protein Names: | G21; Heme carrier protein 1; PCFT/HCP1; Solute carrier family 46 member 1 |
| Protein Family: | Proton-coupled folate transporter |
| UniProt Gene Name: | SLC46A1 |
| UniProt Entry Name: | PCFT_HUMAN |
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