Anti-SLC39A4 Antibody (CAB3454)
- SKU:
- CAB3454
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Signal Transduction
Frequently bought together:
Description
| 抗体名: | Anti-SLC39A4 Antibody |
| 抗体コード: | CAB3454 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB IHC |
| 反応性: | Human, Mouse, Rat |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 23-327 of human SLC39A4 (NP_570901.2). |
| 申し込み: | WB IHC |
| 推奨希釈: | WB 1:500 - 1:2000 IHC 1:50 - 1:100 |
| 反応性: | Human, Mouse, Rat |
| ポジティブサンプル: | MCF7, 293T, Mouse liver |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 23-327 of human SLC39A4 (NP_570901.2). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | SPPA GLLS LLTS GQGA LDQE ALGG LLNT LADR VHCA NGPC GKCL SVED ALGL GEPE GSGL PPGP VLEA RYVA RLSA AAVL YLSN PEGT CEDA RAGL WASH ADHL LALL ESPK ALTP GLSW LLQR MQAR AAGQ TPKT ACVD IPQL LEEA VGAG APGS AGGV LAAL LDHV RSGS CFHA LPSP QYFV DFVF QQHS SEVP MTLA ELSA LMQR LGVG REAH SDHS HRHR GASS RDPV PLIS SSNS SSVW DTVC LSAR DVMA AYGL SEQA GVTP EAWA QLSP ALLQ QQLS GACT SQSR PPVQ DQLS QSER Y |
| 遺伝子ID: | 55630 |
| Uniprot: | Q6P5W5 |
| セルラーロケーション: | Cell membrane, Multi-pass membrane protein, Recycling endosome membrane |
| 計算された分子量: | 66kDa/68kDa |
| 観察された分子量: | 75kDa |
| 同義語: | SLC39A4, AEZ, AWMS2, ZIP4 |
| バックグラウンド: | This gene encodes a member of the zinc/iron-regulated transporter-like protein (ZIP) family. The encoded protein localizes to cell membranes and is required for zinc uptake in the intestine. Mutations in this gene result in acrodermatitis enteropathica. Multiple transcript variants encoding different isoforms have been found for this gene. |
| UniProt Protein Function: | SLC39A4: Plays an important role in cellular zinc homeostasis as a zinc transporter. Regulated in response to zinc availability. Defects in SLC39A4 are the cause of acrodermatitis enteropathica zinc-deficiency type (AEZ). AEZ is a rare autosomal recessive disease caused by the inability to absorb sufficient zinc. The clinical features are growth retardation, immune system dysfunction, alopecia, severe dermatitis, diarrhea and occasionally mental disorders. All these manifestations are reversible with zinc supplementation. Without zinc therapy this disease is fatal. Belongs to the ZIP transporter (TC 2.A.5) family. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Transporter, SLC family; Transporter; Membrane protein, multi-pass; Membrane protein, integral Chromosomal Location of Human Ortholog: 8q24.3 Cellular Component: recycling endosome membrane; cytoplasmic membrane-bound vesicle; apical plasma membrane; integral to membrane; plasma membrane Molecular Function:zinc ion transmembrane transporter activity Biological Process: cellular zinc ion homeostasis; transmembrane transport Disease: Acrodermatitis Enteropathica, Zinc-deficiency Type |
| NCBI Summary: | This gene encodes a member of the zinc/iron-regulated transporter-like protein (ZIP) family. The encoded protein localizes to cell membranes and is required for zinc uptake in the intestine. Mutations in this gene result in acrodermatitis enteropathica. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2013] |
| UniProt Code: | Q6P5W5 |
| NCBI GenInfo Identifier: | 296452970 |
| NCBI Gene ID: | 55630 |
| NCBI Accession: | Q6P5W5.3 |
| UniProt Secondary Accession: | Q6P5W5,Q7L5S5, Q9H6T8, Q9NXC4, |
| UniProt Related Accession: | Q6P5W5 |
| Molecular Weight: | 647 |
| NCBI Full Name: | Zinc transporter ZIP4 |
| NCBI Synonym Full Names: | solute carrier family 39 (zinc transporter), member 4 |
| NCBI Official Symbol: | SLC39A4 |
| NCBI Official Synonym Symbols: | AEZ; ZIP4; AWMS2 |
| NCBI Protein Information: | zinc transporter ZIP4; zrt- and Irt-like protein 4 |
| UniProt Protein Name: | Zinc transporter ZIP4 |
| UniProt Synonym Protein Names: | Solute carrier family 39 member 4; Zrt- and Irt-like protein 4; ZIP-4 |
| Protein Family: | Zinc transporter |
| UniProt Gene Name: | SLC39A4 |
| UniProt Entry Name: | S39A4_HUMAN |
 | Western blot analysis of extracts of various cell lines, using SLC39A4 antibody (CAB3454) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s. |
 | Immunohistochemistry of paraffin-embedded human colon carcinoma using SLC39A4 antibody (CAB3454) at dilution of 1:100 (40x lens). |
 | Immunohistochemistry of paraffin-embedded rat liver using SLC39A4 antibody (CAB3454) at dilution of 1:100 (40x lens). |
 | Immunohistochemistry of paraffin-embedded mouse lung using SLC39A4 antibody (CAB3454) at dilution of 1:100 (40x lens). |
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