Anti-SLC22A12 Antibody (CAB5118)
- SKU:
- CAB5118
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Signal Transduction
Frequently bought together:
Description
| 抗体名: | Anti-SLC22A12 Antibody |
| 抗体コード: | CAB5118 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB |
| 反応性: | Human, Mouse, Rat |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 30-150 of human SLC22A12 (NP_653186.2). |
| 申し込み: | WB |
| 推奨希釈: | WB 1:1000 - 1:2000 |
| 反応性: | Human, Mouse, Rat |
| ポジティブサンプル: | 293T, HeLa, HepG2, Mouse kidney, Rat kidney |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 30-150 of human SLC22A12 (NP_653186.2). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | WLCT QSML ENFS AAVP SHRC WAPL LDNS TAQA SILG SLSP EALL AISI PPGP NQRP HQCR RFRQ PQWQ LLDP NATA TSWS EADT EPCV DGWV YDRS IFTS TIVA KWNL VCDS HALK PMAQ S |
| 遺伝子ID: | 116085 |
| Uniprot: | Q96S37 |
| セルラーロケーション: | Cell membrane, Multi-pass membrane protein |
| 計算された分子量: | 35kDa/47kDa/56kDa/59kDa |
| 観察された分子量: | 75kDa |
| 同義語: | SLC22A12, OAT4L, RST, URAT1 |
| バックグラウンド: | The protein encoded by this gene is a member of the organic anion transporter (OAT) family, and it acts as a urate transporter to regulate urate levels in blood. This protein is an integral membrane protein primarily found in epithelial cells of the proximal tubule of the kidney. An elevated level of serum urate, hyperuricemia, is associated with increased incidences of gout, and mutations in this gene cause renal hypouricemia type 1. Alternative splicing results in multiple transcript variants. |
| UniProt Protein Function: | SLC22A12: Required for efficient urate re-absorption in the kidney. Regulates blood urate levels. Mediates saturable urate uptake by facilitating the exchange of urate against organic anions. Defects in SLC22A12 are the cause of hypouricemia renal type 1 (RHUC1). A disorder characterized by impaired uric acid reabsorption at the apical membrane of proximal renal tubule cells, and high urinary urate excretion. Patients often appear asymptomatic, but may be subject to exercise-induced acute renal failure, chronic renal dysfunction and nephrolithiasis. Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Membrane protein, multi-pass; Transporter, SLC family; Membrane protein, integral; Transporter Chromosomal Location of Human Ortholog: 11q13.1 Cellular Component: brush border membrane; apical plasma membrane; integral to membrane; plasma membrane Molecular Function:urate transmembrane transporter activity; PDZ domain binding Biological Process: response to drug; urate transport; urate metabolic process; cellular homeostasis; organic acid transport; transmembrane transport Disease: Hypouricemia, Renal, 1 |
| NCBI Summary: | The protein encoded by this gene is a member of the organic anion transporter (OAT) family, and it acts as a urate transporter to regulate urate levels in blood. This protein is an integral membrane protein primarily found in epithelial cells of the proximal tubule of the kidney. An elevated level of serum urate, hyperuricemia, is associated with increased incidences of gout, and mutations in this gene cause renal hypouricemia type 1. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2013] |
| UniProt Code: | Q96S37 |
| NCBI GenInfo Identifier: | 74732700 |
| NCBI Gene ID: | 116085 |
| NCBI Accession: | Q96S37.1 |
| UniProt Related Accession: | Q96S37 |
| Molecular Weight: | Predicted Molecular Mass: 11.5kDaAccurate Molecular Mass: 12kDa |
| NCBI Full Name: | Solute carrier family 22 member 12 |
| NCBI Synonym Full Names: | solute carrier family 22 member 12 |
| NCBI Official Symbol: | SLC22A12 |
| NCBI Official Synonym Symbols: | RST; OAT4L; URAT1 |
| NCBI Protein Information: | solute carrier family 22 member 12 |
| UniProt Protein Name: | Solute carrier family 22 member 12 |
| UniProt Synonym Protein Names: | Organic anion transporter 4-like protein; Renal-specific transporter; RST; Urate anion exchanger 1 |
| UniProt Gene Name: | SLC22A12 |
| UniProt Entry Name: | S22AC_HUMAN |
 | Western blot analysis of extracts of various cell lines, using SLC22A12 antibody (CAB5118) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 30s. |
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