Anti-SLC16A3 Antibody (CAB10548)
- SKU:
- CAB10548
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Signal Transduction
Frequently bought together:
Description
| 抗体名: | Anti-SLC16A3 Antibody |
| 抗体コード: | CAB10548 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB |
| 反応性: | Human, Rat |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 371-465 of human SLC16A3 (NP_004198.1). |
| 申し込み: | WB |
| 推奨希釈: | WB 1:500 - 1:2000 |
| 反応性: | Human, Rat |
| ポジティブサンプル: | HT-1080, SW620, MCF7, Rat skeletal muscle |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 371-465 of human SLC16A3 (NP_004198.1). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | PPSG GKLL DATH VYMY VFIL AGAE VLTS SLIL LLGN FFCI RKKP KEPQ PEVA AAEE EKLH KPPA DSGV DLRE VEHF LKAE PEKN GEVV HTPE TSV |
| 遺伝子ID: | 9123 |
| Uniprot: | O15427 |
| セルラーロケーション: | Cell membrane, Multi-pass membrane protein |
| 計算された分子量: | 49kDa |
| 観察された分子量: | 49kDa |
| 同義語: | SLC16A3, MCT 3, MCT 4, MCT-3, MCT-4, MCT3, MCT4 |
| バックグラウンド: |
| UniProt Protein Function: | SLC16A3: Proton-linked monocarboxylate transporter. Catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and the ketone bodies acetoacetate, beta-hydroxybutyrate and acetate. Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family. |
| UniProt Protein Details: | Protein type:Membrane protein, multi-pass; Transporter; Membrane protein, integral; Transporter, SLC family Chromosomal Location of Human Ortholog: 17q25 Cellular Component: nuclear membrane; membrane; integral to plasma membrane; plasma membrane; actin cytoskeleton Molecular Function:monocarboxylic acid transmembrane transporter activity; symporter activity; lactate transmembrane transporter activity; secondary active monocarboxylate transmembrane transporter activity Biological Process: cellular metabolic process; monocarboxylic acid transport; pyruvate metabolic process; blood coagulation; leukocyte migration; transmembrane transport |
| NCBI Summary: | Lactic acid and pyruvate transport across plasma membranes is catalyzed by members of the proton-linked monocarboxylate transporter (MCT) family, which has been designated solute carrier family-16. Each MCT appears to have slightly different substrate and inhibitor specificities and transport kinetics, which are related to the metabolic requirements of the tissues in which it is found. The MCTs, which include MCT1 (SLC16A1; MIM 600682) and MCT2 (SLC16A7; MIM 603654), are characterized by 12 predicted transmembrane domains (Price et al., 1998 [PubMed 9425115]).[supplied by OMIM, Mar 2008] |
| UniProt Code: | O15427 |
| NCBI GenInfo Identifier: | 6225705 |
| NCBI Gene ID: | 9123 |
| NCBI Accession: | O15427.1 |
| UniProt Secondary Accession: | O15427,Q2M1P8, B3KXG8, |
| UniProt Related Accession: | O15427 |
| Molecular Weight: | |
| NCBI Full Name: | Monocarboxylate transporter 4 |
| NCBI Synonym Full Names: | solute carrier family 16 (monocarboxylate transporter), member 3 |
| NCBI Official Symbol: | SLC16A3 |
| NCBI Official Synonym Symbols: | MCT3; MCT4; MCT 3; MCT 4; MCT-3; MCT-4 |
| NCBI Protein Information: | monocarboxylate transporter 4; monocarboxylate transporter 3; solute carrier family 16 (monocarboxylic acid transporters), member 3; solute carrier family 16, member 3 (monocarboxylic acid transporter 4) |
| UniProt Protein Name: | Monocarboxylate transporter 4 |
| UniProt Synonym Protein Names: | Solute carrier family 16 member 3 |
| Protein Family: | Monocarboxylate transporter |
| UniProt Gene Name: | SLC16A3 |
| UniProt Entry Name: | MOT4_HUMAN |
 | Western blot analysis of extracts of various cell lines, using SLC16A3 antibody (CAB10548) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 15s. |
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