Anti-SLC10A2 Antibody (CAB12846)
- SKU:
- CAB12846
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Signal Transduction
Frequently bought together:
Description
| 抗体名: | Anti-SLC10A2 Antibody |
| 抗体コード: | CAB12846 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB |
| 反応性: | Human, Mouse, Rat |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 289-348 of human SLC10A2 (NP_000443.1). |
| 申し込み: | WB |
| 推奨希釈: | WB 1:500 - 1:2000 |
| 反応性: | Human, Mouse, Rat |
| ポジティブサンプル: | HT-29, Mouse small intestine, Mouse kidney, Rat small intestine, Rat liver |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 289-348 of human SLC10A2 (NP_000443.1). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | FPLI YSIF QLAF AAIF LGFY VAYK KCHG KNKA EIPE SKEN GTEP ESSF YKAN GGFQ PDEK |
| 遺伝子ID: | 6555 |
| Uniprot: | Q12908 |
| セルラーロケーション: | Membrane, Multi-pass membrane protein |
| 計算された分子量: | 37kDa |
| 観察された分子量: | 38kDa |
| 同義語: | SLC10A2, ASBT, IBAT, ISBT, NTCP2, PBAM |
| バックグラウンド: | This gene encodes a sodium/bile acid cotransporter. This transporter is the primary mechanism for uptake of intestinal bile acids by apical cells in the distal ileum. Bile acids are the catabolic product of cholesterol metabolism, so this protein is also critical for cholesterol homeostasis. Mutations in this gene cause primary bile acid malabsorption (PBAM); muatations in this gene may also be associated with other diseases of the liver and intestines, such as familial hypertriglyceridemia (FHTG). |
| UniProt Protein Function: | ASBT: Plays a critical role in the sodium-dependent reabsorption of bile acids from the lumen of the small intestine. Plays a key role in cholesterol metabolism. Defects in SLC10A2 are a cause of primary bile acid malabsorption (PBAM). PBAM is an idiopathic intestinal disorder associated with congenital diarrhea, steatorrhea, interruption of the enterohepatic circulation of bile acids, and reduced plasma cholesterol levels. Belongs to the bile acid:sodium symporter (BASS) (TC 2.A.28) family. |
| UniProt Protein Details: | Protein type:Membrane protein, integral; Membrane protein, multi-pass; Transporter Chromosomal Location of Human Ortholog: 13q33.1 Cellular Component: integral to plasma membrane; plasma membrane Molecular Function:bile acid:sodium symporter activity Biological Process: bile acid and bile salt transport; transport Disease: Bile Acid Malabsorption, Primary |
| NCBI Summary: | This gene encodes a sodium/bile acid cotransporter. This transporter is the primary mechanism for uptake of intestinal bile acids by apical cells in the distal ileum. Bile acids are the catabolic product of cholesterol metabolism, so this protein is also critical for cholesterol homeostasis. Mutations in this gene cause primary bile acid malabsorption (PBAM); muatations in this gene may also be associated with other diseases of the liver and intestines, such as familial hypertriglyceridemia (FHTG). [provided by RefSeq, Mar 2010] |
| UniProt Code: | Q12908 |
| NCBI GenInfo Identifier: | 322510055 |
| NCBI Gene ID: | 6555 |
| NCBI Accession: | Q12908.2 |
| UniProt Secondary Accession: | Q12908,Q13839, A1L4F4, |
| UniProt Related Accession: | Q12908 |
| Molecular Weight: | 38kDa |
| NCBI Full Name: | Ileal sodium/bile acid cotransporter |
| NCBI Synonym Full Names: | solute carrier family 10 member 2 |
| NCBI Official Symbol: | SLC10A2 |
| NCBI Official Synonym Symbols: | ASBT; IBAT; ISBT; PBAM; NTCP2 |
| NCBI Protein Information: | ileal sodium/bile acid cotransporter |
| UniProt Protein Name: | Ileal sodium/bile acid cotransporter |
| UniProt Synonym Protein Names: | Apical sodium-dependent bile acid transporter; ASBT; Ileal Na(+)/bile acid cotransporter; Ileal sodium-dependent bile acid transporter; IBAT; ISBT; Na(+)-dependent ileal bile acid transporter; Sodium/taurocholate cotransporting polypeptide, ileal; Solute carrier family 10 member 2 |
| Protein Family: | Ileal sodium/bile acid cotransporter |
| UniProt Gene Name: | SLC10A2 |
 | Western blot analysis of extracts of various cell lines, using SLC10A2 antibody (CAB12846) at 1:3000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 30s. |
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