Anti-SLAMF6 Antibody (CAB10338)
- SKU:
- CAB10338
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Immunology
Frequently bought together:
Description
| 抗体名: | Anti-SLAMF6 Antibody |
| 抗体コード: | CAB10338 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB |
| 反応性: | Human, Mouse, Rat |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant protein of human SLAMF6 |
| 申し込み: | WB |
| 推奨希釈: | WB 1:500 - 1:2000 |
| 反応性: | Human, Mouse, Rat |
| ポジティブサンプル: | Jurkat, Mouse lung, Mouse spleen, Rat liver |
| 免疫原: | Recombinant protein of human SLAMF6 |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | Email for sequence |
| 遺伝子ID: | 114836 |
| Uniprot: | Q96DU3 |
| セルラーロケーション: | Cell membrane, Single-pass type I membrane protein |
| 計算された分子量: | 24kDa/37kDa |
| 観察された分子量: | 70kDa |
| 同義語: | SLAMF6, CD352, KALI, KALIb, Ly108, NTB-A, NTBA, SF2000 |
| バックグラウンド: | The protein encoded by this gene is a type I transmembrane protein, belonging to the CD2 subfamily of the immunoglobulin superfamily. This encoded protein is expressed on Natural killer (NK), T, and B lymphocytes. It undergoes tyrosine phosphorylation and associates with the Src homology 2 domain-containing protein (SH2D1A) as well as with SH2 domain-containing phosphatases (SHPs). It functions as a coreceptor in the process of NK cell activation. It can also mediate inhibitory signals in NK cells from X-linked lymphoproliferative patients. Alternative splicing results in multiple transcript variants encoding distinct isoforms. |
| UniProt Protein Function: | SLAMF6: Triggers cytolytic activity only in natural killer cells (NK) expressing high surface densities of natural cytotoxicity receptors. 3 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Membrane protein, integral; Receptor, misc. Chromosomal Location of Human Ortholog: 1q23.2 Cellular Component: plasma membrane Molecular Function:protein binding Biological Process: positive regulation of interferon-gamma production; positive regulation of interleukin-17 production; positive regulation of natural killer cell mediated cytotoxicity; regulation of immune response |
| NCBI Summary: | The protein encoded by this gene is a type I transmembrane protein, belonging to the CD2 subfamily of the immunoglobulin superfamily. This encoded protein is expressed on Natural killer (NK), T, and B lymphocytes. It undergoes tyrosine phosphorylation and associates with the Src homology 2 domain-containing protein (SH2D1A) as well as with SH2 domain-containing phosphatases (SHPs). It functions as a coreceptor in the process of NK cell activation. It can also mediate inhibitory signals in NK cells from X-linked lymphoproliferative patients. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, May 2010] |
| UniProt Code: | Q96DU3 |
| NCBI GenInfo Identifier: | 205830927 |
| NCBI Gene ID: | 114836 |
| NCBI Accession: | Q96DU3.3 |
| UniProt Secondary Accession: | Q96DU3,Q14CF0, Q5TAS4, Q5TAS6, Q5TAT3, Q96DV0, A6NMW2 B2R8X8, |
| UniProt Related Accession: | Q96DU3 |
| Molecular Weight: | 24,976 Da |
| NCBI Full Name: | SLAM family member 6 |
| NCBI Synonym Full Names: | SLAM family member 6 |
| NCBI Official Symbol: | SLAMF6 |
| NCBI Official Synonym Symbols: | KALI; NTBA; CD352; KALIb; Ly108; NTB-A; SF2000 |
| NCBI Protein Information: | SLAM family member 6 |
| UniProt Protein Name: | SLAM family member 6 |
| UniProt Synonym Protein Names: | Activating NK receptor; NK-T-B-antigen; NTB-A; CD_antigen: CD352 |
| Protein Family: | SLAM family |
| UniProt Gene Name: | SLAMF6 |
| UniProt Entry Name: | SLAF6_HUMAN |
 | Western blot analysis of extracts of Jurkat cells, using SLAMF6 antibody (CAB10338) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 15s. |
 | Western blot analysis of extracts of various cell lines, using SLAMF6 antibody (CAB10338) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit (RM00021). Exposure time: 10s. |
View AllClose