Anti-SKIL Antibody (CAB5844)
- SKU:
- CAB5844
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Epigenetics and Nuclear Signaling
Description
抗体名: | Anti-SKIL Antibody |
抗体コード: | CAB5844 |
抗体サイズ: | 20uL, 50uL, 100uL |
申し込み: | WB IHC |
反応性: | Human, Mouse, Rat |
宿主種: | Rabbit |
免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 420-684 of human SKIL (NP_001234937.1). |
申し込み: | WB IHC |
推奨希釈: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 |
反応性: | Human, Mouse, Rat |
ポジティブサンプル: | Mouse skeletal muscle, Mouse heart, Rat skeletal muscle, Rat heart |
免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 420-684 of human SKIL (NP_001234937.1). |
精製方法: | Affinity purification |
ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
アイソタイプ: | IgG |
順序: | SQSK ELTK TEAS KSIS RQSE KAHS SGKL QKTV SYPD VSLE EQEK MDLK TSRE LCSR LDAS ISNN STSK RKSE SATC NLVR DINK VGIG LVAA ASSP LLVK DVIC EDDK GKIM EEVM RTYL KQQE KLNL ILQK KQQL QMEV KMLS SSKS MKEL TEEQ QNLQ KELE SLQN EHAQ RMEE FYVE QKDL EKKL EQIM KQKC TCDS NLEK DKEA EYAG QLAE LRQR LDHA EADR QELQ DELR QERE ARQK LEMM IKEL KLQI LKSS KTAK E |
遺伝子ID: | 6498 |
Uniprot: | P12757 |
セルラーロケーション: | |
計算された分子量: | 44kDa/46kDa/71kDa/74kDa/76kDa |
観察された分子量: | 77kDa |
同義語: | SKIL, SNO, SnoA, SnoI, SnoN |
バックグラウンド: | The protein encoded by this gene is a component of the SMAD pathway, which regulates cell growth and differentiation through transforming growth factor-beta (TGFB). In the absence of ligand, the encoded protein binds to the promoter region of TGFB-responsive genes and recruits a nuclear repressor complex. TGFB signaling causes SMAD3 to enter the nucleus and degrade this protein, allowing these genes to be activated. Four transcript variants encoding three different isoforms have been found for this gene. |
UniProt Protein Function: | SKIL: May have regulatory role in cell division or differentiation in response to extracellular signals. Interacts with SMAD2, SMAD3 and RNF111. Isoform 1 interacts with WWP1. Isoform SNON and isoform SNOA are widely expressed. Highest expression is found in skeletal muscle, followed by placenta and lung. Lowest expression in heart, brain and pancreas. Isoform SNOI expression is restricted to skeletal muscle. Belongs to the SKI family. 5 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Chromosomal Location of Human Ortholog: 3q26 Cellular Component: acrosome; cytoplasm; nucleoplasm; nucleus; PML body; protein complex Molecular Function:chromatin binding; DNA binding; protein binding; protein complex binding; protein domain specific binding; SMAD binding; transcription corepressor activity Biological Process: blastocyst formation; cell cycle arrest; gene expression; lymphocyte homeostasis; negative regulation of cell differentiation; negative regulation of transcription from RNA polymerase II promoter; negative regulation of transforming growth factor beta receptor signaling pathway; positive regulation of axonogenesis; regulation of apoptosis; response to antibiotic; response to cytokine stimulus; skeletal muscle development; spermatogenesis; transcription initiation from RNA polymerase II promoter; transcription, DNA-dependent; transforming growth factor beta receptor signaling pathway |
NCBI Summary: | The protein encoded by this gene is a component of the SMAD pathway, which regulates cell growth and differentiation through transforming growth factor-beta (TGFB). In the absence of ligand, the encoded protein binds to the promoter region of TGFB-responsive genes and recruits a nuclear repressor complex. TGFB signaling causes SMAD3 to enter the nucleus and degrade this protein, allowing these genes to be activated. Four transcript variants encoding three different isoforms have been found for this gene. [provided by RefSeq, Oct 2011] |
UniProt Code: | P12757 |
NCBI GenInfo Identifier: | 313104010 |
NCBI Gene ID: | 6498 |
NCBI Accession: | P12757.2 |
UniProt Secondary Accession: | P12757,O00464, P12756, Q07501, A6NGT1, B4DT50, |
UniProt Related Accession: | P12757 |
Molecular Weight: | 74,784 Da |
NCBI Full Name: | Ski-like protein |
NCBI Synonym Full Names: | SKI-like proto-oncogene |
NCBI Official Symbol: | SKIL |
NCBI Official Synonym Symbols: | SNO; SnoA; SnoI; SnoN |
NCBI Protein Information: | ski-like protein |
UniProt Protein Name: | Ski-like protein |
UniProt Synonym Protein Names: | Ski-related oncogene; Ski-related protein |
Protein Family: | Ski-like protein |
UniProt Gene Name: | SKIL |
UniProt Entry Name: | SKIL_HUMAN |