Anti-SIPA1 Antibody (CAB19867)[KO Validated]

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SKU:
CAB19867
Product type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Cell Biology
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Description

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抗体名:Anti-SIPA1 Antibody [KO Validated]
抗体コード:CAB19867
抗体サイズ:20uL, 50uL, 100uL
申し込み:WB IHC
反応性:Human, Mouse
宿主種:Rabbit
免疫原:Recombinant protein of human SIPA1.
申し込み:WB IHC
推奨希釈:WB 1:500 - 1:2000 IHC 1:100 - 1:200
反応性:Human, Mouse
ポジティブサンプル:HeLa
免疫原:Recombinant protein of human SIPA1.
精製方法:Affinity purification
ストレージバッファ:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
アイソタイプ:IgG
順序:Email for sequence
遺伝子ID:6494
Uniprot:Q96FS4
セルラーロケーション:Cytoplasm, Endomembrane system, Nucleus, Peripheral membrane protein, perinuclear region
計算された分子量:112kDa
観察された分子量:130KDa
Anti-SIPA1 Antibody [KO Validated] (CAB19867)Western blot analysis of extracts from normal (control) and SIPA1 knockout (KO) HeLa cells, using SIPA1 antibody (CAB19867) at 1:3000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 1s.
同義語:SIPA1, SPA1
バックグラウンド:The product of this gene is a mitogen induced GTPase activating protein (GAP). It exhibits a specific GAP activity for Ras-related regulatory proteins Rap1 and Rap2, but not for Ran or other small GTPases. This protein may also hamper mitogen-induced cell cycle progression when abnormally or prematurely expressed. It is localized to the perinuclear region. Two alternatively spliced variants encoding the same isoform have been characterized to date.
UniProt Protein Function:SIPA1: GTPase activator for the nuclear Ras-related regulatory proteins Rap1 and Rap2 in vitro, converting it to the putatively inactive GDP-bound state.
UniProt Protein Details:

Protein type:GAPs; GAPs, Ras

Chromosomal Location of Human Ortholog: 11q13

Cellular Component: cytosol; nucleus

Molecular Function:GTPase activator activity; protein binding

Biological Process: cell proliferation; signal transduction

NCBI Summary:The product of this gene is a mitogen induced GTPase activating protein (GAP). It exhibits a specific GAP activity for Ras-related regulatory proteins Rap1 and Rap2, but not for Ran or other small GTPases. This protein may also hamper mitogen-induced cell cycle progression when abnormally or prematurely expressed. It is localized to the perinuclear region. Two alternatively spliced variants encoding the same isoform have been characterized to date. [provided by RefSeq, Jul 2008]
UniProt Code:Q96FS4
NCBI GenInfo Identifier:20455286
NCBI Gene ID:6494
NCBI Accession:Q96FS4.1
UniProt Secondary Accession:Q96FS4,O14518, O60484, O60618, Q2YD83,
UniProt Related Accession:Q96FS4
Molecular Weight:112,149 Da
NCBI Full Name:Signal-induced proliferation-associated protein 1
NCBI Synonym Full Names:signal-induced proliferation-associated 1
NCBI Official Symbol:SIPA1  
NCBI Official Synonym Symbols:SPA1  
NCBI Protein Information:signal-induced proliferation-associated protein 1
UniProt Protein Name:Signal-induced proliferation-associated protein 1
UniProt Synonym Protein Names:GTPase-activating protein Spa-1; p130 SPA-1
Protein Family:Signal-induced proliferation-associated protein
UniProt Gene Name:SIPA1  
UniProt Entry Name:SIPA1_HUMAN
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